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Protein

Mitochondrial carrier protein LEU5

Gene

LEU5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ADP transport Source: GO_Central
  • coenzyme A transport Source: SGD
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-31067-MONOMER
ReactomeiR-SCE-196783 Coenzyme A biosynthesis

Protein family/group databases

TCDBi2.A.29.12.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier protein LEU5
Gene namesi
Name:LEU5
Ordered Locus Names:YHR002W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR002W
SGDiS000001044 LEU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 47Helical; Name=1Sequence analysisAdd BLAST17
Transmembranei103 – 119Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei136 – 153Helical; Name=3Sequence analysisAdd BLAST18
Transmembranei208 – 228Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei269 – 285Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei325 – 347Helical; Name=6Sequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906831 – 357Mitochondrial carrier protein LEU5Add BLAST357

Proteomic databases

MaxQBiP38702
PaxDbiP38702
PRIDEiP38702

Interactioni

Protein-protein interaction databases

BioGridi36427, 122 interactors
DIPiDIP-8164N
STRINGi4932.YHR002W

Structurei

3D structure databases

ProteinModelPortaliP38702
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 122Solcar 1Add BLAST92
Repeati130 – 231Solcar 2Add BLAST102
Repeati262 – 354Solcar 3Add BLAST93

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149156
HOGENOMiHOG000165726
InParanoidiP38702
KOiK15084
OMAiTHDTVGD
OrthoDBiEOG092C592A

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P38702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL
60 70 80 90 100
IAPLDRIKIL FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA
110 120 130 140 150
TLLRIFPYAA VKFVAYEQIR NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT
160 170 180 190 200
YPLDLVRVRL AYETEHKRVK LGRIIKKIYK EPASATLIKN DYIPNWFCHW
210 220 230 240 250
CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY SVLELSEDDE
260 270 280 290 300
LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK
310 320 330 340 350
TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER

MKWNFGI
Length:357
Mass (Da):40,825
Last modified:February 1, 1995 - v1
Checksum:i16266B2CD4B996D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10555 Genomic DNA Translation: AAB68424.1
BK006934 Genomic DNA Translation: DAA06689.1
PIRiS46795
RefSeqiNP_011865.1, NM_001179132.1

Genome annotation databases

EnsemblFungiiYHR002W; YHR002W; YHR002W
GeneIDi856391
KEGGisce:YHR002W

Similar proteinsi

Entry informationi

Entry nameiLEU5_YEAST
AccessioniPrimary (citable) accession number: P38702
Secondary accession number(s): D3DKR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

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