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Entry version 160 (23 Feb 2022)
Sequence version 1 (01 Feb 1995)
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Protein

Signal recognition particle subunit SRP68

Gene

SRP68

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:7925282).

The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity).

The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity).

Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (By similarity).

The SRP complex possibly participates in the elongation arrest function (PubMed:7925282).

By similarity1 Publication

Miscellaneous

Present with 6280 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-1799339, SRP-dependent cotranslational protein targeting to membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal recognition particle subunit SRP68
Alternative name(s):
Signal recognition particle 68 kDa protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRP68
Ordered Locus Names:YPL243W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000006164, SRP68

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPL243W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signal recognition particle

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001352321 – 599Signal recognition particle subunit SRP68Add BLAST599

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38687

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38687

PRoteomics IDEntifications database

More...
PRIDEi
P38687

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38687

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with SRP72 (By similarity). SRP68-SRP72 heterodimer formation is stabilized by the presence of 7SL RNA (By similarity).

Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14 (PubMed:7925282, PubMed:11352936).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35920, 79 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-609, Signal recognition particle

Database of interacting proteins

More...
DIPi
DIP-6742N

Protein interaction database and analysis system

More...
IntActi
P38687, 20 interactors

Molecular INTeraction database

More...
MINTi
P38687

STRING: functional protein association networks

More...
STRINGi
4932.YPL243W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38687, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni559 – 599DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi559 – 582Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRP68 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2460, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011856

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018649_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38687

Identification of Orthologs from Complete Genome Data

More...
OMAi
LAYIKYN

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15481, SRP68-RBD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3450.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026258, SRP68
IPR034652, SRP68-RBD
IPR038253, SRP68_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12860, PTHR12860, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16969, SRP68, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038995, SRP68, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38687-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAYSPIIAT YGNRAEQFLE TDSDFAKYHA KLNKKLQHLR SRCHLVTKDT
60 70 80 90 100
KKYSSKNKYG EINSEDYDNK TKLIGVLILL HAERDLALAE TLKLRARQRG
110 120 130 140 150
KLKKSEEKVL STRLKKACKT ADKLVNVTQN EQQWITRAQY LAFAKLVHSE
160 170 180 190 200
YLINGKRFKR KDNAKISNNL ALVFAALEHL KNLSLLAEEV VDNIVNKYQY
210 220 230 240 250
SLKQYAGNLI TTPEINNFIV ERVQSDENKD DELVKLLLDN GFNMKKITTS
260 270 280 290 300
TEDQKVTTNI NWRSFNAKII DAEVAQFLEQ GLSIHPTQIT QYTQRLSKLE
310 320 330 340 350
KALDRHEFFI ANHDDQDDID EMVENSSENN QIILAYIKYN ILLTSISRER
360 370 380 390 400
DLFTHLWNQW LKLNTSLPSK LTKYKEMERI VKNLTKYLSD IMELPGVYSD
410 420 430 440 450
DELLSQLDLC KLYFQLFLNT GCLSVLYQSK GRYMEALALY VDAYRRLENK
460 470 480 490 500
LSEIESLDEI LLPANLLSLN SVRSLQKRIE NGGNSVITLA EYEKRNHGGS
510 520 530 540 550
LGKYDLTVIE KLDSKKILPT DIQLKNLFPL KPKMLPIPSK PTLFDLAFNY
560 570 580 590
ITYDKQEPSA SQVKDSVTET ESISQTPISN EQTEGEPKKK RGFLGLFGR
Length:599
Mass (Da):69,006
Last modified:February 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i241749187CE95499
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L35177 Genomic DNA Translation: AAA53401.1
Z67751 Genomic DNA Translation: CAA91601.1
Z73599 Genomic DNA Translation: CAA97964.1
BK006949 Genomic DNA Translation: DAA11194.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S47928

NCBI Reference Sequences

More...
RefSeqi
NP_015081.1, NM_001184057.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPL243W_mRNA; YPL243W; YPL243W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPL243W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35177 Genomic DNA Translation: AAA53401.1
Z67751 Genomic DNA Translation: CAA91601.1
Z73599 Genomic DNA Translation: CAA97964.1
BK006949 Genomic DNA Translation: DAA11194.1
PIRiS47928
RefSeqiNP_015081.1, NM_001184057.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35920, 79 interactors
ComplexPortaliCPX-609, Signal recognition particle
DIPiDIP-6742N
IntActiP38687, 20 interactors
MINTiP38687
STRINGi4932.YPL243W

PTM databases

iPTMnetiP38687

Proteomic databases

MaxQBiP38687
PaxDbiP38687
PRIDEiP38687

Genome annotation databases

EnsemblFungiiYPL243W_mRNA; YPL243W; YPL243W
GeneIDi855833
KEGGisce:YPL243W

Organism-specific databases

SGDiS000006164, SRP68
VEuPathDBiFungiDB:YPL243W

Phylogenomic databases

eggNOGiKOG2460, Eukaryota
GeneTreeiENSGT00390000011856
HOGENOMiCLU_018649_2_1_1
InParanoidiP38687
OMAiLAYIKYN

Enzyme and pathway databases

ReactomeiR-SCE-1799339, SRP-dependent cotranslational protein targeting to membrane

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38687
RNActiP38687, protein

Family and domain databases

CDDicd15481, SRP68-RBD, 1 hit
Gene3Di1.10.3450.40, 1 hit
InterProiView protein in InterPro
IPR026258, SRP68
IPR034652, SRP68-RBD
IPR038253, SRP68_N_sf
PANTHERiPTHR12860, PTHR12860, 1 hit
PfamiView protein in Pfam
PF16969, SRP68, 1 hit
PIRSFiPIRSF038995, SRP68, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRP68_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38687
Secondary accession number(s): D6W3C8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: February 23, 2022
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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