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Protein

Carboxy-cis,cis-muconate cyclase

Gene

NCU04071

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes a syn cycloisomerization. Also possesses mle activity.

Catalytic activityi

3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate.

Pathwayi: beta-ketoadipate pathway

This protein is involved in step 1 of the subpathway that synthesizes 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate.
Proteins known to be involved in this subpathway in this organism are:
  1. Carboxy-cis,cis-muconate cyclase (NCU04071)
This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3-carboxy-cis,cis-muconate from 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1491
Active sitei1971
Active sitei2131
Active sitei2751

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: GO_Central
  • carboxy-cis,cis-muconate cyclase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayi
UPA00157;UER00308

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxy-cis,cis-muconate cyclase (EC:5.5.1.5)
Alternative name(s):
3-carboxy-cis,cis-muconate lactonizing enzyme
Short name:
CMLE
Gene namesi
ORF Names:NCU04071
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 5, Linkage Group VI

Organism-specific databases

EuPathDBiFungiDB:NCU04071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001711272 – 366Carboxy-cis,cis-muconate cyclaseAdd BLAST365

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1366
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP38677
SMRiP38677
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38677

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.Curated

Phylogenomic databases

HOGENOMiHOG000216586
InParanoidiP38677
KOiK14334
OMAiHPRWVAM
OrthoDBiEOG092C335T

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR019405 Lactonase_7-beta_prop
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLHHLMIGT WTPPGAIFTV QFDDEKLTCK LIKRTEIPQD EPISWMTFDH
60 70 80 90 100
ERKNIYGAAM KKWSSFAVKS PTEIVHEASH PIGGHPRAND ADTNTRAIFL
110 120 130 140 150
LAAKQPPYAV YANPFYKFAG YGNVFSVSET GKLEKNVQNY EYQENTGIHG
160 170 180 190 200
MVFDPTETYL YSADLTANKL WTHRKLASGE VELVGSVDAP DPGDHPRWVA
210 220 230 240 250
MHPTGNYLYA LMEAGNRICE YVIDPATHMP VYTHHSFPLI PPGIPDRDPE
260 270 280 290 300
TGKGLYRADV CALTFSGKYM FASSRANKFE LQGYIAGFKL RDCGSIEKQL
310 320 330 340 350
FLSPTPTSGG HSNAVSPCPW SDEWMAITDD QEGWLEIYRW KDEFLHRVAR
360
VRIPEPGFGM NAIWYD
Length:366
Mass (Da):41,329
Last modified:January 23, 2007 - v3
Checksum:iE71BA50509E72873
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27538 mRNA Translation: AAA21020.1
CM002241 Genomic DNA Translation: EAA28450.1
PIRiA55525
RefSeqiXP_957686.1, XM_952593.2

Genome annotation databases

EnsemblFungiiEAA28450; EAA28450; NCU04071
GeneIDi3873776
KEGGincr:NCU04071

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27538 mRNA Translation: AAA21020.1
CM002241 Genomic DNA Translation: EAA28450.1
PIRiA55525
RefSeqiXP_957686.1, XM_952593.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JOFX-ray2.50A/B/C/D/E/F/G/H2-366[»]
ProteinModelPortaliP38677
SMRiP38677
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA28450; EAA28450; NCU04071
GeneIDi3873776
KEGGincr:NCU04071

Organism-specific databases

EuPathDBiFungiDB:NCU04071

Phylogenomic databases

HOGENOMiHOG000216586
InParanoidiP38677
KOiK14334
OMAiHPRWVAM
OrthoDBiEOG092C335T

Enzyme and pathway databases

UniPathwayi
UPA00157;UER00308

Miscellaneous databases

EvolutionaryTraceiP38677

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR019405 Lactonase_7-beta_prop
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCMLE_NEUCR
AccessioniPrimary (citable) accession number: P38677
Secondary accession number(s): Q7RV80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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