Abo

Functionⁱ

Catalytic activityⁱ

UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.By similarity

UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.By similarity

Cofactorⁱ

Mn²⁺By similarityNote: Binds 1 Mn²⁺ ion per subunit.By similarity

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	105	UDP-N-acetyl-galactosamineBy similarity	1
Metal bindingⁱ	190	ManganeseBy similarity	1
Metal bindingⁱ	192	ManganeseBy similarity	1
Binding siteⁱ	212	Glycoprotein fucosyl-galactosyl groupBy similarity	1
Binding siteⁱ	224	Glycoprotein fucosyl-galactosyl groupBy similarity	1
Active siteⁱ	282	NucleophileBy similarity	1
Binding siteⁱ	282	Glycoprotein fucosyl-galactosyl groupBy similarity	1
Binding siteⁱ	305	Glycoprotein fucosyl-galactosyl groupBy similarity	1

GO - Molecular functionⁱ

alpha-1,3-galactosyltransferase activity Source: MGI
antigen binding Source: MGI
fucosylgalactoside 3-alpha-galactosyltransferase activity
Source: MGI
Inferred from direct assayⁱ
- 11278752
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
Source: MGI
Inferred from direct assayⁱ
- 11278752
manganese ion binding Source: MGI
nucleotide binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
glycolipid biosynthetic process Source: GO_Central
lipid glycosylation Source: GO_Central
protein glycosylation Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	2.4.1.37 3477 2.4.1.40 3477
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT6 Glycosyltransferase Family 6

CAZyⁱ

GT6 Glycosyltransferase Family 6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histo-blood group ABO system transferase Alternative name(s): Cis-AB transferase Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC:2.4.1.40By similarity) Glycoprotein-fucosylgalactoside alpha-galactosyltransferase (EC:2.4.1.37By similarity) Histo-blood group A transferase Short name: A transferase Histo-blood group B transferase Short name: B transferase NAGAT
Gene namesⁱ	Name:Abo
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2135738 Abo

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 13	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	14 – 34	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	35 – 332	LumenalSequence analysisAdd BLAST	298

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000157293	1 – 332	Histo-blood group ABO system transferaseAdd BLAST		332

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	92	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	P38649
PRIDEⁱ	P38649

PTM databases

iPTMnetⁱ	P38649
PhosphoSitePlusⁱ	P38649

Expressionⁱ

Tissue specificityⁱ

Submaxillary glands (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000015787
ExpressionAtlasⁱ	P38649 baseline and differential
Genevisibleⁱ	P38649 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000099964

STRINGⁱ

10090.ENSMUSP00000099964

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P38649
SMRⁱ	P38649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	100 – 102	UDP-N-acetyl-galactosamine bindingBy similarity		3
Regionⁱ	190 – 192	UDP-N-acetyl-galactosamine bindingBy similarity		3

Domainⁱ

The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 6 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFQJ Eukaryota ENOG4111IPQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000022032
HOGENOMⁱ	HOG000234339
HOVERGENⁱ	HBG003563
InParanoidⁱ	P38649
KEGG Orthology (KO) More...KOⁱ	K00709
PhylomeDBⁱ	P38649
TreeFamⁱ	TF330991

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR005076 Glyco_trans_6 IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR10462 PTHR10462, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03414 Glyco_transf_6, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P38649-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNLRGRPKCN FLHLGILPFA VFVLVFFGYL FLSFRSQNLG HPGAVTRNAY 
        60         70         80         90        100
LQPRVLKPTR KDVLVLTPWL APIIWEGTFN IDILNEQFRI RNTTIGLTVF 
       110        120        130        140        150
AIKKYVVFLK LFLETAEQHF MVGHKVIYYV FTDRPADVPQ VILGAGRQLV 
       160        170        180        190        200
VLTVRNYTRW QDVSMHRMEM ISHFSERRFL REVDYLVCAD ADMKFSDHVG 
       210        220        230        240        250
VEILSTFFGT LHPGFYSSSR EAFTYERRPQ SQAYIPWDRG DFYYGGAFFG 
       260        270        280        290        300
GSVLEVYHLT KACHEAMMED KANGIEPVWH DESYLNKYLL YHKPTKVLSP 
       310        320        330 
EYLWDQQLLG WPSIMKKLRY VAVPKDHQAI RN

Length:332

Mass (Da):38,777

Last modified:December 16, 2008 - v2

Checksum:ⁱC48DB1090EA0D3E4

GO

Sequence cautionⁱ

The sequence CAM23695 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	77	G → R in BAC29005 (PubMed:16141072).Curated	1
Sequence conflictⁱ	109	L → I in BAC29005 (PubMed:16141072).Curated	1
Sequence conflictⁱ	160	W → C in BAC28473 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB041038 Genomic DNA Translation: BAB20559.1 AB041039 mRNA Translation: BAB20560.1 AK033786 mRNA Translation: BAC28473.1 AK035261 mRNA Translation: BAC29005.1 AL773563 Genomic DNA Translation: CAM23695.1 Sequence problems. AL773563 Genomic DNA Translation: CAM23696.1 CH466542 Genomic DNA Translation: EDL08332.1 BC116759 mRNA Translation: AAI16760.1 BC116761 mRNA Translation: AAI16762.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15811.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001277373.1, NM_001290444.1 NP_109643.3, NM_030718.5
UniGeneⁱ	Mm.160386

Genome annotation databases

Ensemblⁱ	ENSMUST00000102900; ENSMUSP00000099964; ENSMUSG00000015787
GeneIDⁱ	80908
KEGGⁱ	mmu:80908
UCSC genome browser More...UCSCⁱ	uc008iwb.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P38649	UPI0003D77978		MOUSE		389
UPI000A319ABB		MUSCR		332
Histo-blood group ABO system transferase		MOUSE		334

Protein	Similar proteins		Species	Score	Length
P38649	UPI0003D77978		MOUSE		389
UPI000A319ABB		MUSCR		332
UPI00090464D4		PANPR		367
UPI0006B87ECC		HUMAN		298
UPI000732BB17		MACMU		367
+142

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB041038 Genomic DNA Translation: BAB20559.1 AB041039 mRNA Translation: BAB20560.1 AK033786 mRNA Translation: BAC28473.1 AK035261 mRNA Translation: BAC29005.1 AL773563 Genomic DNA Translation: CAM23695.1 Sequence problems. AL773563 Genomic DNA Translation: CAM23696.1 CH466542 Genomic DNA Translation: EDL08332.1 BC116759 mRNA Translation: AAI16760.1 BC116761 mRNA Translation: AAI16762.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15811.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001277373.1, NM_001290444.1 NP_109643.3, NM_030718.5
UniGeneⁱ	Mm.160386

3D structure databases

ProteinModelPortalⁱ	P38649
SMRⁱ	P38649
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000099964

STRINGⁱ

10090.ENSMUSP00000099964

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT6 Glycosyltransferase Family 6

CAZyⁱ

GT6 Glycosyltransferase Family 6

PTM databases

iPTMnetⁱ	P38649
PhosphoSitePlusⁱ	P38649

Proteomic databases

PaxDbⁱ	P38649
PRIDEⁱ	P38649

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000102900; ENSMUSP00000099964; ENSMUSG00000015787
GeneIDⁱ	80908
KEGGⁱ	mmu:80908
UCSC genome browser More...UCSCⁱ	uc008iwb.2 mouse

Organism-specific databases

CTDⁱ	28
MGIⁱ	MGI:2135738 Abo

Phylogenomic databases

eggNOGⁱ	ENOG410IFQJ Eukaryota ENOG4111IPQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000022032
HOGENOMⁱ	HOG000234339
HOVERGENⁱ	HBG003563
InParanoidⁱ	P38649
KEGG Orthology (KO) More...KOⁱ	K00709
PhylomeDBⁱ	P38649
TreeFamⁱ	TF330991

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
BRENDAⁱ	2.4.1.37 3477 2.4.1.40 3477

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P38649
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000015787
ExpressionAtlasⁱ	P38649 baseline and differential
Genevisibleⁱ	P38649 MM

Family and domain databases

Gene3Dⁱ	3.90.550.10, 1 hit
InterProⁱ	View protein in InterPro IPR005076 Glyco_trans_6 IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR10462 PTHR10462, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03414 Glyco_transf_6, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BGAT_MOUSE
Accessionⁱ	P38649Primary (citable) accession number: P38649 Secondary accession number(s): A2AL98 , Q8BZH3, Q8BZQ6, Q9EQW2, Q9EQW3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
	Last sequence update:	December 16, 2008
	Last modified:	June 20, 2018
	This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P38649 (BGAT_MOUSE)

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Histo-blood group ABO system transferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Golgi apparatus

Extracellular region or secreted

Golgi apparatus

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ