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Protein

Histo-blood group ABO system transferase

Gene

Abo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.By similarity
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.By similarity

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105UDP-N-acetyl-galactosamineBy similarity1
Metal bindingi190ManganeseBy similarity1
Metal bindingi192ManganeseBy similarity1
Binding sitei212Glycoprotein fucosyl-galactosyl groupBy similarity1
Binding sitei224Glycoprotein fucosyl-galactosyl groupBy similarity1
Active sitei282NucleophileBy similarity1
Binding sitei282Glycoprotein fucosyl-galactosyl groupBy similarity1
Binding sitei305Glycoprotein fucosyl-galactosyl groupBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDAi2.4.1.37 3477
2.4.1.40 3477
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT6 Glycosyltransferase Family 6

Names & Taxonomyi

Protein namesi
Recommended name:
Histo-blood group ABO system transferase
Alternative name(s):
Cis-AB transferase
Fucosylglycoprotein 3-alpha-galactosyltransferase
Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC:2.4.1.40By similarity)
Glycoprotein-fucosylgalactoside alpha-galactosyltransferase (EC:2.4.1.37By similarity)
Histo-blood group A transferase
Short name:
A transferase
Histo-blood group B transferase
Short name:
B transferase
NAGAT
Gene namesi
Name:Abo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2135738 Abo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini35 – 332LumenalSequence analysisAdd BLAST298

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001572931 – 332Histo-blood group ABO system transferaseAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP38649
PRIDEiP38649

PTM databases

iPTMnetiP38649
PhosphoSitePlusiP38649

Expressioni

Tissue specificityi

Submaxillary glands (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000015787
ExpressionAtlasiP38649 baseline and differential
GenevisibleiP38649 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099964

Structurei

3D structure databases

ProteinModelPortaliP38649
SMRiP38649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 102UDP-N-acetyl-galactosamine bindingBy similarity3
Regioni190 – 192UDP-N-acetyl-galactosamine bindingBy similarity3

Domaini

The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.

Sequence similaritiesi

Belongs to the glycosyltransferase 6 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFQJ Eukaryota
ENOG4111IPQ LUCA
GeneTreeiENSGT00400000022032
HOGENOMiHOG000234339
HOVERGENiHBG003563
InParanoidiP38649
KOiK00709
PhylomeDBiP38649
TreeFamiTF330991

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR005076 Glyco_trans_6
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR10462 PTHR10462, 1 hit
PfamiView protein in Pfam
PF03414 Glyco_transf_6, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P38649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLRGRPKCN FLHLGILPFA VFVLVFFGYL FLSFRSQNLG HPGAVTRNAY
60 70 80 90 100
LQPRVLKPTR KDVLVLTPWL APIIWEGTFN IDILNEQFRI RNTTIGLTVF
110 120 130 140 150
AIKKYVVFLK LFLETAEQHF MVGHKVIYYV FTDRPADVPQ VILGAGRQLV
160 170 180 190 200
VLTVRNYTRW QDVSMHRMEM ISHFSERRFL REVDYLVCAD ADMKFSDHVG
210 220 230 240 250
VEILSTFFGT LHPGFYSSSR EAFTYERRPQ SQAYIPWDRG DFYYGGAFFG
260 270 280 290 300
GSVLEVYHLT KACHEAMMED KANGIEPVWH DESYLNKYLL YHKPTKVLSP
310 320 330
EYLWDQQLLG WPSIMKKLRY VAVPKDHQAI RN
Length:332
Mass (Da):38,777
Last modified:December 16, 2008 - v2
Checksum:iC48DB1090EA0D3E4
GO

Sequence cautioni

The sequence CAM23695 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77G → R in BAC29005 (PubMed:16141072).Curated1
Sequence conflicti109L → I in BAC29005 (PubMed:16141072).Curated1
Sequence conflicti160W → C in BAC28473 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041038 Genomic DNA Translation: BAB20559.1
AB041039 mRNA Translation: BAB20560.1
AK033786 mRNA Translation: BAC28473.1
AK035261 mRNA Translation: BAC29005.1
AL773563 Genomic DNA Translation: CAM23695.1 Sequence problems.
AL773563 Genomic DNA Translation: CAM23696.1
CH466542 Genomic DNA Translation: EDL08332.1
BC116759 mRNA Translation: AAI16760.1
BC116761 mRNA Translation: AAI16762.1
CCDSiCCDS15811.1
RefSeqiNP_001277373.1, NM_001290444.1
NP_109643.3, NM_030718.5
UniGeneiMm.160386

Genome annotation databases

EnsembliENSMUST00000102900; ENSMUSP00000099964; ENSMUSG00000015787
GeneIDi80908
KEGGimmu:80908
UCSCiuc008iwb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBGAT_MOUSE
AccessioniPrimary (citable) accession number: P38649
Secondary accession number(s): A2AL98
, Q8BZH3, Q8BZQ6, Q9EQW2, Q9EQW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: December 16, 2008
Last modified: June 20, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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