UniProtKB - P38637 (STS1_YEAST)
Protein
Tethering factor for nuclear proteasome STS1
Gene
STS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. Required for efficient chromosome segregation. Restores protein transport and ribosomal RNA stability.6 Publications
Miscellaneous
Present with 2120 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- proteasome-nuclear membrane anchor activity Source: GO_Central
GO - Biological processi
- chromosome segregation Source: SGD
- nuclear protein quality control by the ubiquitin-proteasome system Source: SGD
- proteasome localization Source: SGD
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Tethering factor for nuclear proteasome STS1Alternative name(s): Dumbbell former protein 8 SEC23 suppressor 1 |
Gene namesi | Name:STS1 Synonyms:DBF8, SSM5 Ordered Locus Names:YIR011C ORF Names:YIB11C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YIR011C |
SGDi | S000001450, STS1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079792 | 1 – 319 | Tethering factor for nuclear proteasome STS1Add BLAST | 319 |
Proteomic databases
PaxDbi | P38637 |
PRIDEi | P38637 |
Interactioni
Subunit structurei
Binds the proteasome.
Interacts with karyopherin SRP1 and proteasome subunit RPN11.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 35003, 396 interactors |
DIPi | DIP-7670N |
IntActi | P38637, 1 interactor |
STRINGi | 4932.YIR011C |
Miscellaneous databases
RNActi | P38637, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 49 | Poly-Glu | 7 | |
Compositional biasi | 303 – 308 | Poly-Asn | 6 |
Sequence similaritiesi
Belongs to the cut8/STS1 family.Curated
Phylogenomic databases
eggNOGi | ENOG502RNK4, Eukaryota |
HOGENOMi | CLU_054606_1_0_1 |
InParanoidi | P38637 |
OMAi | VLQTICE |
Family and domain databases
Gene3Di | 1.20.58.1590, 1 hit |
InterProi | View protein in InterPro IPR013868, Cut8/Sts1_fam IPR038422, Cut8/Sts1_sf |
PANTHERi | PTHR28032, PTHR28032, 1 hit |
Pfami | View protein in Pfam PF08559, Cut8, 1 hit |
i Sequence
Sequence statusi: Complete.
P38637-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMGFEWGFKP SSKITQSTVS SQGTGNVMIP TAGVKQKRRY ANEEQEEEEL
60 70 80 90 100
PRNKNVMKYG GVSKRRPQPG SLIRGQPLPL QRGMELMNKN QLQQLLVDLM
110 120 130 140 150
TKHPEIQQSV HTRVIGLDFS IQKCLDMLKQ KSEAVYQSIP YNRSYESNKL
160 170 180 190 200
DDYAFVRMKP QILEFLNCLV DFILDNIPPR LENLHASLKF LDICTELVIK
210 220 230 240 250
LPRFELASNN YYYDKCIEQL SHVWCTLIEH VARDRIILLA DNSSVWKSHM
260 270 280 290 300
TRLQVYNEHS NGLLERPLQL FKSLDMGSPS AASSSTLSLQ ESIIYHHDTM
310
TANENNNNSG SAATDSPFN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 231 | V → I in CAA53515 (PubMed:7925484).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z37996 Genomic DNA Translation: CAA86081.1 U12437 Genomic DNA Translation: AAA21413.1 X79743 Genomic DNA Translation: CAB38099.1 X75916 Genomic DNA Translation: CAA53515.1 AY557878 Genomic DNA Translation: AAS56204.1 BK006942 Genomic DNA Translation: DAA08557.1 |
PIRi | S48355 |
RefSeqi | NP_012276.1, NM_001179533.1 |
Genome annotation databases
EnsemblFungii | YIR011C_mRNA; YIR011C; YIR011C |
GeneIDi | 854828 |
KEGGi | sce:YIR011C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z37996 Genomic DNA Translation: CAA86081.1 U12437 Genomic DNA Translation: AAA21413.1 X79743 Genomic DNA Translation: CAB38099.1 X75916 Genomic DNA Translation: CAA53515.1 AY557878 Genomic DNA Translation: AAS56204.1 BK006942 Genomic DNA Translation: DAA08557.1 |
PIRi | S48355 |
RefSeqi | NP_012276.1, NM_001179533.1 |
3D structure databases
SMRi | P38637 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35003, 396 interactors |
DIPi | DIP-7670N |
IntActi | P38637, 1 interactor |
STRINGi | 4932.YIR011C |
Proteomic databases
PaxDbi | P38637 |
PRIDEi | P38637 |
Genome annotation databases
EnsemblFungii | YIR011C_mRNA; YIR011C; YIR011C |
GeneIDi | 854828 |
KEGGi | sce:YIR011C |
Organism-specific databases
EuPathDBi | FungiDB:YIR011C |
SGDi | S000001450, STS1 |
Phylogenomic databases
eggNOGi | ENOG502RNK4, Eukaryota |
HOGENOMi | CLU_054606_1_0_1 |
InParanoidi | P38637 |
OMAi | VLQTICE |
Miscellaneous databases
PROi | PR:P38637 |
RNActi | P38637, protein |
Family and domain databases
Gene3Di | 1.20.58.1590, 1 hit |
InterProi | View protein in InterPro IPR013868, Cut8/Sts1_fam IPR038422, Cut8/Sts1_sf |
PANTHERi | PTHR28032, PTHR28032, 1 hit |
Pfami | View protein in Pfam PF08559, Cut8, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STS1_YEAST | |
Accessioni | P38637Primary (citable) accession number: P38637 Secondary accession number(s): D6VVU1, P35188 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names