Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein SIC1

Gene

SIC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate and inhibitor of the cyclin-dependent protein kinase CDC28. Its activity could be important for faithful segregation of chromosomes to daughter cells. It acts in response to a signal from a post-start checkpoint.1 Publication

Miscellaneous

Present with 768 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: SGD
  • negative regulation of macroautophagy Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32230-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SIC1
Alternative name(s):
CDK inhibitor p40
Gene namesi
Name:SIC1
Synonyms:SDB25
Ordered Locus Names:YLR079W
ORF Names:L9449.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR079W
SGDiS000004069 SIC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi173T → A: Impairs the ability to arrest the cell cycle. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977511 – 284Protein SIC1Add BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Phosphothreonine; by PHO851 Publication1
Modified residuei33Phosphothreonine1 Publication1
Modified residuei76Phosphoserine1 Publication1
Modified residuei173PhosphothreonineCombined sources1 Publication1
Modified residuei198PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei268Lysine derivative1
Modified residuei272Lysine derivative1
Modified residuei274Lysine derivative1

Post-translational modificationi

Phosphorylated by cyclin-dependent kinases CDC28 and PHO85 in association with G1-cyclins, promoting degradation of SIC1 and exit form G1.2 Publications
May contain a covalently attached chromophore.
The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38634
PaxDbiP38634
PRIDEiP38634

PTM databases

iPTMnetiP38634

Interactioni

Subunit structurei

Interacts with HOG1.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi31352, 713 interactors
DIPiDIP-6817N
ELMiP38634
IntActiP38634, 23 interactors
MINTiP38634
STRINGi4932.YLR079W

Structurei

3D structure databases

DisProtiDP00631
ProteinModelPortaliP38634
SMRiP38634
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 135Asp/Glu-rich (acidic)Add BLAST12
Compositional biasi200 – 206Asp/Glu-rich (acidic)7

Phylogenomic databases

HOGENOMiHOG000141931
InParanoidiP38634
KOiK03085
OMAiINDEYAV
OrthoDBiEOG092C3UOG

Sequencei

Sequence statusi: Complete.

P38634-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPSTPPRSR GTRYLAQPSG NTSSSALMQG QKTPQKPSQN LVPVTPSTTK
60 70 80 90 100
SFKNAPLLAP PNSNMGMTSP FNGLTSPQRS PFPKSSVKRT LFQFESHDNG
110 120 130 140 150
TVREEQEPLG RVNRILFPTQ QNVDIDAAEE EEEGEVLLPP SRPTSARQLH
160 170 180 190 200
LSLERDEFDQ THRKKIIKDV PGTPSDKVIT FELAKNWNNN SPKNDARSQE
210 220 230 240 250
SEDEEDIIIN PVRVGKNPFA SDELVTQEIR NERKRAMLRE NPDIEDVITY
260 270 280
VNKKGEVVEK RRLTDEEKRR FKPKALFQSR DQEH
Length:284
Mass (Da):32,223
Last modified:October 1, 1994 - v1
Checksum:i7913636340678F78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167I → T in CAA55118 (PubMed:7958845).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01300 Genomic DNA Translation: AAA20052.1
X78309 Genomic DNA Translation: CAA55118.1
Z73251 Genomic DNA Translation: CAA97638.1
U53880 Genomic DNA Translation: AAB67583.1
BK006945 Genomic DNA Translation: DAA09395.1
PIRiS47921
RefSeqiNP_013180.1, NM_001181966.1

Genome annotation databases

EnsemblFungiiYLR079W; YLR079W; YLR079W
GeneIDi850768
KEGGisce:YLR079W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01300 Genomic DNA Translation: AAA20052.1
X78309 Genomic DNA Translation: CAA55118.1
Z73251 Genomic DNA Translation: CAA97638.1
U53880 Genomic DNA Translation: AAB67583.1
BK006945 Genomic DNA Translation: DAA09395.1
PIRiS47921
RefSeqiNP_013180.1, NM_001181966.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V7DX-ray2.31E67-85[»]
DisProtiDP00631
ProteinModelPortaliP38634
SMRiP38634
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31352, 713 interactors
DIPiDIP-6817N
ELMiP38634
IntActiP38634, 23 interactors
MINTiP38634
STRINGi4932.YLR079W

PTM databases

iPTMnetiP38634

Proteomic databases

MaxQBiP38634
PaxDbiP38634
PRIDEiP38634

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR079W; YLR079W; YLR079W
GeneIDi850768
KEGGisce:YLR079W

Organism-specific databases

EuPathDBiFungiDB:YLR079W
SGDiS000004069 SIC1

Phylogenomic databases

HOGENOMiHOG000141931
InParanoidiP38634
KOiK03085
OMAiINDEYAV
OrthoDBiEOG092C3UOG

Enzyme and pathway databases

BioCyciYEAST:G3O-32230-MONOMER

Miscellaneous databases

PROiPR:P38634

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSIC1_YEAST
AccessioniPrimary (citable) accession number: P38634
Secondary accession number(s): D6VY79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again