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Entry version 206 (29 Sep 2021)
Sequence version 2 (02 Aug 2002)
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Protein

V-type proton ATPase catalytic subunit A

Gene

ATP6V1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).

V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091).

In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).

May play a role in neurite development and synaptic connectivity (PubMed:29668857).

1 PublicationBy similarity2 Publications

(Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi250 – 257ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS03781-MONOMER

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P38606

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-77387, Insulin receptor recycling
R-HSA-917977, Transferrin endocytosis and recycling
R-HSA-9639288, Amino acids regulate mTORC1
R-HSA-983712, Ion channel transport

SIGNOR Signaling Network Open Resource

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SIGNORi
P38606

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase catalytic subunit A (EC:7.1.2.2By similarity)
Short name:
V-ATPase subunit A
Alternative name(s):
V-ATPase 69 kDa subunit
Vacuolar ATPase isoform VA68
Vacuolar proton pump subunit alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP6V1A
Synonyms:ATP6A1, ATP6V1A1, VPP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:851, ATP6V1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607027, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P38606

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000114573

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cutis laxa, autosomal recessive, 2D (ARCL2D)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of cutis laxa, a disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, and a general connective tissue weakness. Most ARCL2D patients exhibit severe hypotonia as well as cardiovascular and neurologic involvement.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07860672G → D in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505037EnsemblClinVar.1
Natural variantiVAR_078607338R → C in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505036EnsemblClinVar.1
Epileptic encephalopathy, infantile or early childhood, 3 (IECEE3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE3 is an autosomal dominant form characterized by onset of seizures in the first years of life.The severity of the phenotype is highly variable: some patients may be non-verbal and non-ambulatory with spastic quadriparesis and poor eye contact, whereas others have moderate intellectual disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08099527P → R in IECEE3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1553709380EnsemblClinVar.1
Natural variantiVAR_080996100D → Y in IECEE3; loss-of-function variant leading to increased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 PublicationCorresponds to variant dbSNP:rs1553709855EnsemblClinVar.1
Natural variantiVAR_080998349D → N in IECEE3; gain-of-function variant leading to decreased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 PublicationCorresponds to variant dbSNP:rs1553710664EnsemblClinVar.1
Natural variantiVAR_080999371D → G in IECEE3; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi256K → Q: Complete loss of interaction with Rabies virus protein M; when associated with Q-279. 1 Publication1
Mutagenesisi279E → Q: Complete loss of interaction with Rabies virus protein M; when associated with Q-256. 1 Publication1

Keywords - Diseasei

Disease variant, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
523

MalaCards human disease database

More...
MalaCardsi
ATP6V1A
MIMi617403, phenotype
618012, phenotype

Open Targets

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OpenTargetsi
ENSG00000114573

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25152

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P38606, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4295756

Drug and drug target database

More...
DrugBanki
DB00630, Alendronic acid
DB06733, Bafilomycin A1
DB06734, Bafilomycin B1
DB01077, Etidronic acid
DB01133, Tiludronic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP6V1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
22096378

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001445601 – 617V-type proton ATPase catalytic subunit AAdd BLAST617
Isoform 2 (identifier: P38606-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei136PhosphothreonineCombined sources1
Modified residuei384Phosphoserine; by AMPKCombined sources1
Isoform 2 (identifier: P38606-2)
Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-384 by AMPK downregulates its enzyme activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P38606

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P38606

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P38606

MaxQB - The MaxQuant DataBase

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MaxQBi
P38606

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P38606

PeptideAtlas

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PeptideAtlasi
P38606

PRoteomics IDEntifications database

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PRIDEi
P38606

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55303 [P38606-1]
6360

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P38606, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P38606

MetOSite database of methionine sulfoxide sites

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MetOSitei
P38606

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P38606

SwissPalm database of S-palmitoylation events

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SwissPalmi
P38606

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114573, Expressed in Brodmann (1909) area 23 and 251 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P38606, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P38606, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000114573, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (PubMed:33065002). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (PubMed:33065002). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, and subunits e and Ac45 (PubMed:33065002).

Interacts with WFS1 (PubMed:23035048).

2 Publications

(Microbial infection) Interacts with Rabies virus protein M; this interaction promotes virion uncoating.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107007, 193 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P38606

Protein interaction database and analysis system

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IntActi
P38606, 108 interactors

Molecular INTeraction database

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MINTi
P38606

STRING: functional protein association networks

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STRINGi
9606.ENSP00000273398

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P38606, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1617
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38606

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1352, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00550000074787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_008162_3_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P38606

Identification of Orthologs from Complete Genome Data

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OMAi
RIVKTFW

Database of Orthologous Groups

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OrthoDBi
241249at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P38606

TreeFam database of animal gene trees

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TreeFami
TF300811

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1140.10, 1 hit
2.40.30.20, 1 hit
3.40.50.300, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00309, ATP_synth_A_arch, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031686, ATP-synth_a_Xtn
IPR023366, ATP_synth_asu-like_sf
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034, ATPase_F1/V1_b/a_C
IPR005725, ATPase_V1-cplx_asu
IPR027417, P-loop_NTPase
IPR022878, V-ATPase_asu

The PANTHER Classification System

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PANTHERi
PTHR43607, PTHR43607, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF02874, ATP-synt_ab_N, 1 hit
PF16886, ATP-synt_ab_Xtn, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01042, V-ATPase_V1_A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P38606-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFSKLPKIL DEDKESTFGY VHGVSGPVVT ACDMAGAAMY ELVRVGHSEL
60 70 80 90 100
VGEIIRLEGD MATIQVYEET SGVSVGDPVL RTGKPLSVEL GPGIMGAIFD
110 120 130 140 150
GIQRPLSDIS SQTQSIYIPR GVNVSALSRD IKWDFTPCKN LRVGSHITGG
160 170 180 190 200
DIYGIVSENS LIKHKIMLPP RNRGTVTYIA PPGNYDTSDV VLELEFEGVK
210 220 230 240 250
EKFTMVQVWP VRQVRPVTEK LPANHPLLTG QRVLDALFPC VQGGTTAIPG
260 270 280 290 300
AFGCGKTVIS QSLSKYSNSD VIIYVGCGER GNEMSEVLRD FPELTMEVDG
310 320 330 340 350
KVESIMKRTA LVANTSNMPV AAREASIYTG ITLSEYFRDM GYHVSMMADS
360 370 380 390 400
TSRWAEALRE ISGRLAEMPA DSGYPAYLGA RLASFYERAG RVKCLGNPER
410 420 430 440 450
EGSVSIVGAV SPPGGDFSDP VTSATLGIVQ VFWGLDKKLA QRKHFPSVNW
460 470 480 490 500
LISYSKYMRA LDEYYDKHFT EFVPLRTKAK EILQEEEDLA EIVQLVGKAS
510 520 530 540 550
LAETDKITLE VAKLIKDDFL QQNGYTPYDR FCPFYKTVGM LSNMIAFYDM
560 570 580 590 600
ARRAVETTAQ SDNKITWSII REHMGDILYK LSSMKFKDPL KDGEAKIKSD
610
YAQLLEDMQN AFRSLED
Length:617
Mass (Da):68,304
Last modified:August 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB409A8731D772CB
GO
Isoform 2 (identifier: P38606-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:584
Mass (Da):64,736
Checksum:i6F677073A4B4A48B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVW8C9JVW8_HUMAN
V-type proton ATPase catalytic subu...
ATP6V1A
221Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JA17C9JA17_HUMAN
V-type proton ATPase catalytic subu...
ATP6V1A
184Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDJ3F8WDJ3_HUMAN
V-type proton ATPase catalytic subu...
ATP6V1A
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71S → C in AAA83249 (PubMed:8463241).Curated1
Sequence conflicti89 – 90EL → DV in AAA83249 (PubMed:8463241).Curated2
Sequence conflicti211V → A in AAA83249 (PubMed:8463241).Curated1
Sequence conflicti211V → A in AAF14870 (PubMed:10931946).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08099411D → N Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs746407800Ensembl.1
Natural variantiVAR_08099527P → R in IECEE3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1553709380EnsemblClinVar.1
Natural variantiVAR_07860672G → D in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505037EnsemblClinVar.1
Natural variantiVAR_080996100D → Y in IECEE3; loss-of-function variant leading to increased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 PublicationCorresponds to variant dbSNP:rs1553709855EnsemblClinVar.1
Natural variantiVAR_080997249P → R Found in a patient with severe developmental disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_078607338R → C in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505036EnsemblClinVar.1
Natural variantiVAR_080998349D → N in IECEE3; gain-of-function variant leading to decreased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 PublicationCorresponds to variant dbSNP:rs1553710664EnsemblClinVar.1
Natural variantiVAR_080999371D → G in IECEE3; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0564081 – 33Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L09235 mRNA Translation: AAA83249.1
AF113129 mRNA Translation: AAF14870.1
BT006672 mRNA Translation: AAP35318.1
AK293804 mRNA Translation: BAH11601.1
AK314779 mRNA Translation: BAG37315.1
AC079944 Genomic DNA No translation available.
AC108693 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79625.1
CH471052 Genomic DNA Translation: EAW79626.1
BC013138 mRNA Translation: AAH13138.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2976.1 [P38606-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
B46091

NCBI Reference Sequences

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RefSeqi
NP_001681.2, NM_001690.3 [P38606-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273398; ENSP00000273398; ENSG00000114573 [P38606-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
523

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:523

UCSC genome browser

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UCSCi
uc003eao.4, human [P38606-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09235 mRNA Translation: AAA83249.1
AF113129 mRNA Translation: AAF14870.1
BT006672 mRNA Translation: AAP35318.1
AK293804 mRNA Translation: BAH11601.1
AK314779 mRNA Translation: BAG37315.1
AC079944 Genomic DNA No translation available.
AC108693 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79625.1
CH471052 Genomic DNA Translation: EAW79626.1
BC013138 mRNA Translation: AAH13138.1
CCDSiCCDS2976.1 [P38606-1]
PIRiB46091
RefSeqiNP_001681.2, NM_001690.3 [P38606-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6WLZelectron microscopy2.90A/B/C1-617[»]
6WM2electron microscopy3.10A/B/C1-617[»]
6WM3electron microscopy3.40A/B/C1-617[»]
6WM4electron microscopy3.60A/B/C1-617[»]
SMRiP38606
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107007, 193 interactors
CORUMiP38606
IntActiP38606, 108 interactors
MINTiP38606
STRINGi9606.ENSP00000273398

Chemistry databases

ChEMBLiCHEMBL4295756
DrugBankiDB00630, Alendronic acid
DB06733, Bafilomycin A1
DB06734, Bafilomycin B1
DB01077, Etidronic acid
DB01133, Tiludronic acid

Protein family/group databases

TCDBi3.A.2.2.4, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

GlyGeniP38606, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiP38606
MetOSiteiP38606
PhosphoSitePlusiP38606
SwissPalmiP38606

Genetic variation databases

BioMutaiATP6V1A
DMDMi22096378

Proteomic databases

EPDiP38606
jPOSTiP38606
MassIVEiP38606
MaxQBiP38606
PaxDbiP38606
PeptideAtlasiP38606
PRIDEiP38606
ProteomicsDBi55303 [P38606-1]
6360

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32600, 189 antibodies

The DNASU plasmid repository

More...
DNASUi
523

Genome annotation databases

EnsembliENST00000273398; ENSP00000273398; ENSG00000114573 [P38606-1]
GeneIDi523
KEGGihsa:523
UCSCiuc003eao.4, human [P38606-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
523
DisGeNETi523

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP6V1A
HGNCiHGNC:851, ATP6V1A
HPAiENSG00000114573, Low tissue specificity
MalaCardsiATP6V1A
MIMi607027, gene
617403, phenotype
618012, phenotype
neXtProtiNX_P38606
OpenTargetsiENSG00000114573
PharmGKBiPA25152
VEuPathDBiHostDB:ENSG00000114573

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1352, Eukaryota
GeneTreeiENSGT00550000074787
HOGENOMiCLU_008162_3_1_1
InParanoidiP38606
OMAiRIVKTFW
OrthoDBi241249at2759
PhylomeDBiP38606
TreeFamiTF300811

Enzyme and pathway databases

BioCyciMetaCyc:HS03781-MONOMER
PathwayCommonsiP38606
ReactomeiR-HSA-1222556, ROS and RNS production in phagocytes
R-HSA-77387, Insulin receptor recycling
R-HSA-917977, Transferrin endocytosis and recycling
R-HSA-9639288, Amino acids regulate mTORC1
R-HSA-983712, Ion channel transport
SIGNORiP38606

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
523, 769 hits in 1038 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATP6V1A, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATP6V1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
523
PharosiP38606, Tbio

Protein Ontology

More...
PROi
PR:P38606
RNActiP38606, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114573, Expressed in Brodmann (1909) area 23 and 251 other tissues
ExpressionAtlasiP38606, baseline and differential
GenevisibleiP38606, HS

Family and domain databases

Gene3Di1.10.1140.10, 1 hit
2.40.30.20, 1 hit
3.40.50.300, 1 hit
HAMAPiMF_00309, ATP_synth_A_arch, 1 hit
InterProiView protein in InterPro
IPR031686, ATP-synth_a_Xtn
IPR023366, ATP_synth_asu-like_sf
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR024034, ATPase_F1/V1_b/a_C
IPR005725, ATPase_V1-cplx_asu
IPR027417, P-loop_NTPase
IPR022878, V-ATPase_asu
PANTHERiPTHR43607, PTHR43607, 1 hit
PfamiView protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF02874, ATP-synt_ab_N, 1 hit
PF16886, ATP-synt_ab_Xtn, 1 hit
SUPFAMiSSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01042, V-ATPase_V1_A, 1 hit
PROSITEiView protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVATA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38606
Secondary accession number(s): B2RBR8
, B7Z1R5, D3DN75, Q53YD9, Q96DY6, Q9UHY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 2, 2002
Last modified: September 29, 2021
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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