ATP6V1A

Functionⁱ

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe²⁺ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857).2 Publications

Catalytic activityⁱ

ATP + H₂O + 4 H⁺(Side 1) = ADP + phosphate + 4 H⁺(Side 2).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	250 – 257	ATPSequence analysis		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
proton-transporting ATPase activity, rotational mechanism
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ATP hydrolysis coupled proton transport Source: InterPro
ATP metabolic process Source: InterPro
cellular iron ion homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28296633
cellular response to increased oxygen levels
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28296633
insulin receptor signaling pathway Source: Reactome
ion transmembrane transport Source: Reactome
regulation of macroautophagy
Source: ParkinsonsUK-UCL
Non-traceable author statementⁱ
- 22982048
transferrin transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Biological process	Hydrogen ion transport, Ion transport, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03781-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Protein family/group databases

TCDBⁱ	3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: V-type proton ATPase catalytic subunit A (EC:7.1.2.2) Short name: V-ATPase subunit A Alternative name(s): V-ATPase 69 kDa subunit Vacuolar ATPase isoform VA68 Vacuolar proton pump subunit alpha
Gene namesⁱ	Name:ATP6V1A Synonyms:ATP6A1, ATP6V1A1, VPP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114573.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:851 ATP6V1A
MIMⁱ	607027 gene
neXtProtⁱ	NX_P38606

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cutis laxa, autosomal recessive, 2D (ARCL2D)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of cutis laxa, a disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, and a general connective tissue weakness. Most ARCL2D patients exhibit severe hypotonia as well as cardiovascular and neurologic involvement.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_078606	72	G → D in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505037Ensembl.		1
Natural variantⁱVAR_078607	338	R → C in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505036Ensembl.		1

Epileptic encephalopathy, infantile or early childhood, 3 (IECEE3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE3 is an autosomal dominant form characterized by onset of seizures in the first years of life.The severity of the phenotype is highly variable: some patients may be non-verbal and non-ambulatory with spastic quadriparesis and poor eye contact, whereas others have moderate intellectual disability.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_080995	27	P → R in IECEE3; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_080996	100	D → Y in IECEE3; loss-of-function variant leading to increased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 Publication	1
Natural variantⁱVAR_080998	349	D → N in IECEE3; gain-of-function variant leading to decreased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 Publication	1
Natural variantⁱVAR_080999	371	D → G in IECEE3; unknown pathological significance. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	523
MalaCards human disease database More...MalaCardsⁱ	ATP6V1A
MIMⁱ	617403 phenotype 618012 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000114573
PharmGKBⁱ	PA25152

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00630 Alendronic acid DB06733 Bafilomycin A1 DB06734 Bafilomycin B1 DB01077 Etidronic acid DB01133 Tiludronic acid

DrugBankⁱ

DB00630 Alendronic acid
DB06733 Bafilomycin A1
DB06734 Bafilomycin B1
DB01077 Etidronic acid
DB01133 Tiludronic acid

Polymorphism and mutation databases

BioMutaⁱ	ATP6V1A
DMDMⁱ	22096378

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000144560	1 – 617	V-type proton ATPase catalytic subunit AAdd BLAST	617
Isoform 2 (identifier: P38606-2)
Initiator methionineⁱ		RemovedCombined sources

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	136	PhosphothreonineCombined sources	1
Modified residueⁱ	384	PhosphoserineCombined sources	1
Isoform 2 (identifier: P38606-2)
Modified residueⁱ	2	N-acetylalanineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P38606
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P38606
PaxDbⁱ	P38606
PeptideAtlas More...PeptideAtlasⁱ	P38606
PRIDEⁱ	P38606
ProteomicsDBⁱ	55303

PTM databases

iPTMnetⁱ	P38606
PhosphoSitePlusⁱ	P38606
SwissPalmⁱ	P38606

Expressionⁱ

Tissue specificityⁱ

High expression in the skin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000114573 Expressed in 238 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_ATP6V1A
ExpressionAtlasⁱ	P38606 baseline and differential
Genevisibleⁱ	P38606 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006910 HPA035083 HPA035084

HPAⁱ

CAB006910
HPA035083
HPA035084

Interactionⁱ

Subunit structureⁱ

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

Protein-protein interaction databases

BioGridⁱ	107007, 103 interactors
IntActⁱ	P38606, 94 interactors
Molecular INTeraction database More...MINTⁱ	P38606
STRINGⁱ	9606.ENSP00000273398

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P38606
SMRⁱ	P38606
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1352 Eukaryota COG1155 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074787
HOGENOMⁱ	HOG000161057
HOVERGENⁱ	HBG053351
InParanoidⁱ	P38606
KEGG Orthology (KO) More...KOⁱ	K02145
OMAⁱ	QQLAKWS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03SR
PhylomeDBⁱ	P38606
TreeFamⁱ	TF300811

Family and domain databases

Gene3Dⁱ	1.10.1140.10, 1 hit 2.40.30.20, 1 hit
HAMAPⁱ	MF_00309 ATP_synth_A_arch, 1 hit
InterProⁱ	View protein in InterPro IPR031686 ATP-synth_a_Xtn IPR023366 ATP_synth_asu-like_sf IPR020003 ATPase_a/bsu_AS IPR004100 ATPase_F1/V1/A1_a/bsu_N IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd IPR024034 ATPase_F1/V1_b/a_C IPR005725 ATPase_V1-cplx_asu IPR027417 P-loop_NTPase IPR022878 V-ATPase_asu
PANTHERⁱ	PTHR43607 PTHR43607, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00006 ATP-synt_ab, 1 hit PF02874 ATP-synt_ab_N, 1 hit PF16886 ATP-synt_ab_Xtn, 1 hit
SUPFAMⁱ	SSF50615 SSF50615, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR01042 V-ATPase_V1_A, 1 hit
PROSITEⁱ	View protein in PROSITE PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P38606-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFSKLPKIL DEDKESTFGY VHGVSGPVVT ACDMAGAAMY ELVRVGHSEL 
        60         70         80         90        100
VGEIIRLEGD MATIQVYEET SGVSVGDPVL RTGKPLSVEL GPGIMGAIFD 
       110        120        130        140        150
GIQRPLSDIS SQTQSIYIPR GVNVSALSRD IKWDFTPCKN LRVGSHITGG 
       160        170        180        190        200
DIYGIVSENS LIKHKIMLPP RNRGTVTYIA PPGNYDTSDV VLELEFEGVK 
       210        220        230        240        250
EKFTMVQVWP VRQVRPVTEK LPANHPLLTG QRVLDALFPC VQGGTTAIPG 
       260        270        280        290        300
AFGCGKTVIS QSLSKYSNSD VIIYVGCGER GNEMSEVLRD FPELTMEVDG 
       310        320        330        340        350
KVESIMKRTA LVANTSNMPV AAREASIYTG ITLSEYFRDM GYHVSMMADS 
       360        370        380        390        400
TSRWAEALRE ISGRLAEMPA DSGYPAYLGA RLASFYERAG RVKCLGNPER 
       410        420        430        440        450
EGSVSIVGAV SPPGGDFSDP VTSATLGIVQ VFWGLDKKLA QRKHFPSVNW 
       460        470        480        490        500
LISYSKYMRA LDEYYDKHFT EFVPLRTKAK EILQEEEDLA EIVQLVGKAS 
       510        520        530        540        550
LAETDKITLE VAKLIKDDFL QQNGYTPYDR FCPFYKTVGM LSNMIAFYDM 
       560        570        580        590        600
ARRAVETTAQ SDNKITWSII REHMGDILYK LSSMKFKDPL KDGEAKIKSD 
       610 
YAQLLEDMQN AFRSLED

Length:617

Mass (Da):68,304

Last modified:August 2, 2002 - v2

Checksum:ⁱDB409A8731D772CB

GO

Isoform 2 (identifier: P38606-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.

« Hide

        10         20         30         40         50
MAGAAMYELV RVGHSELVGE IIRLEGDMAT IQVYEETSGV SVGDPVLRTG 
        60         70         80         90        100
KPLSVELGPG IMGAIFDGIQ RPLSDISSQT QSIYIPRGVN VSALSRDIKW 
       110        120        130        140        150
DFTPCKNLRV GSHITGGDIY GIVSENSLIK HKIMLPPRNR GTVTYIAPPG 
       160        170        180        190        200
NYDTSDVVLE LEFEGVKEKF TMVQVWPVRQ VRPVTEKLPA NHPLLTGQRV 
       210        220        230        240        250
LDALFPCVQG GTTAIPGAFG CGKTVISQSL SKYSNSDVII YVGCGERGNE 
       260        270        280        290        300
MSEVLRDFPE LTMEVDGKVE SIMKRTALVA NTSNMPVAAR EASIYTGITL 
       310        320        330        340        350
SEYFRDMGYH VSMMADSTSR WAEALREISG RLAEMPADSG YPAYLGARLA 
       360        370        380        390        400
SFYERAGRVK CLGNPEREGS VSIVGAVSPP GGDFSDPVTS ATLGIVQVFW 
       410        420        430        440        450
GLDKKLAQRK HFPSVNWLIS YSKYMRALDE YYDKHFTEFV PLRTKAKEIL 
       460        470        480        490        500
QEEEDLAEIV QLVGKASLAE TDKITLEVAK LIKDDFLQQN GYTPYDRFCP 
       510        520        530        540        550
FYKTVGMLSN MIAFYDMARR AVETTAQSDN KITWSIIREH MGDILYKLSS 
       560        570        580 
MKFKDPLKDG EAKIKSDYAQ LLEDMQNAFR SLED

Show »

Length:584

Mass (Da):64,736

Checksum:ⁱ6F677073A4B4A48B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JVW8	C9JVW8_HUMAN	V-type proton ATPase catalytic subu... V-type proton ATPase catalytic subunit A	ATP6V1A	221	Annotation score:
C9JA17	C9JA17_HUMAN	V-type proton ATPase catalytic subu... V-type proton ATPase catalytic subunit A	ATP6V1A	184	Annotation score:
F8WDJ3	F8WDJ3_HUMAN	V-type proton ATPase catalytic subu... V-type proton ATPase catalytic subunit A	ATP6V1A	49	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	71	S → C in AAA83249 (PubMed:8463241).Curated	1
Sequence conflictⁱ	89 – 90	EL → DV in AAA83249 (PubMed:8463241).Curated	2
Sequence conflictⁱ	211	V → A in AAA83249 (PubMed:8463241).Curated	1
Sequence conflictⁱ	211	V → A in AAF14870 (PubMed:10931946).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_080994	11	D → N Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_080995	27	P → R in IECEE3; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_078606	72	G → D in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505037Ensembl.	1
Natural variantⁱVAR_080996	100	D → Y in IECEE3; loss-of-function variant leading to increased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 Publication	1
Natural variantⁱVAR_080997	249	P → R Found in a patient with severe developmental disorder; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_078607	338	R → C in ARCL2D. 1 PublicationCorresponds to variant dbSNP:rs1060505036Ensembl.	1
Natural variantⁱVAR_080998	349	D → N in IECEE3; gain-of-function variant leading to decreased pH in intracellular organelles; affects neurite arborization and impairs the formation and maintenance of excitatory synapses, when tested in a heterologous system; not effect on subcellular location. 1 Publication	1
Natural variantⁱVAR_080999	371	D → G in IECEE3; unknown pathological significance. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056408	1 – 33	Missing in isoform 2. 1 PublicationAdd BLAST		33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L09235 mRNA Translation: AAA83249.1 AF113129 mRNA Translation: AAF14870.1 BT006672 mRNA Translation: AAP35318.1 AK293804 mRNA Translation: BAH11601.1 AK314779 mRNA Translation: BAG37315.1 AC079944 Genomic DNA No translation available. AC108693 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79625.1 CH471052 Genomic DNA Translation: EAW79626.1 BC013138 mRNA Translation: AAH13138.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2976.1 [P38606-1]
PIRⁱ	B46091
NCBI Reference Sequences More...RefSeqⁱ	NP_001681.2, NM_001690.3 [P38606-1]
UniGeneⁱ	Hs.477155

Genome annotation databases

Ensemblⁱ	ENST00000273398; ENSP00000273398; ENSG00000114573 [P38606-1]
GeneIDⁱ	523
KEGGⁱ	hsa:523
UCSC genome browser More...UCSCⁱ	uc003eao.4 human [P38606-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P38606	ATPase H+ transporting V1 subunit A		PANTR		618	UniRef100_P38606
Uncharacterized protein		PANPA		618
ATPase H+ transporting V1 subunit A		GORGO		618
Uncharacterized protein		RHIRO		617
Uncharacterized protein		NOMLE		617
+12

Protein	Similar proteins		Species	Score	Length	Source
P38606	V-type proton ATPase catalytic subunit A		BOVIN		617	UniRef90_P38606
V-type proton ATPase catalytic subunit A		PONAB		617
V-type proton ATPase catalytic subunit A		CHICK		617
V-type proton ATPase catalytic subunit A		PIG		617
V-type proton ATPase catalytic subunit A		MOUSE		617
+347

Protein	Similar proteins		Species	Score	Length	Source
P38606	V-type proton ATPase catalytic subunit A		MOUSE		617	UniRef50_P38606
V-type proton ATPase catalytic subunit A		PONAB		617
V-type proton ATPase catalytic subunit A		BOVIN		617
V-type proton ATPase catalytic subunit A		PIG		617
V-type proton ATPase catalytic subunit A		CHICK		617
+409

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L09235 mRNA Translation: AAA83249.1 AF113129 mRNA Translation: AAF14870.1 BT006672 mRNA Translation: AAP35318.1 AK293804 mRNA Translation: BAH11601.1 AK314779 mRNA Translation: BAG37315.1 AC079944 Genomic DNA No translation available. AC108693 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79625.1 CH471052 Genomic DNA Translation: EAW79626.1 BC013138 mRNA Translation: AAH13138.1
CCDSⁱ	CCDS2976.1 [P38606-1]
PIRⁱ	B46091
RefSeqⁱ	NP_001681.2, NM_001690.3 [P38606-1]
UniGeneⁱ	Hs.477155

3D structure databases

ProteinModelPortalⁱ	P38606
SMRⁱ	P38606
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107007, 103 interactors
IntActⁱ	P38606, 94 interactors
MINTⁱ	P38606
STRINGⁱ	9606.ENSP00000273398

Chemistry databases

DrugBankⁱ	DB00630 Alendronic acid DB06733 Bafilomycin A1 DB06734 Bafilomycin B1 DB01077 Etidronic acid DB01133 Tiludronic acid

DrugBankⁱ

DB00630 Alendronic acid
DB06733 Bafilomycin A1
DB06734 Bafilomycin B1
DB01077 Etidronic acid
DB01133 Tiludronic acid

Protein family/group databases

TCDBⁱ	3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

TCDBⁱ

3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetⁱ	P38606
PhosphoSitePlusⁱ	P38606
SwissPalmⁱ	P38606

Polymorphism and mutation databases

BioMutaⁱ	ATP6V1A
DMDMⁱ	22096378

Proteomic databases

EPDⁱ	P38606
MaxQBⁱ	P38606
PaxDbⁱ	P38606
PeptideAtlasⁱ	P38606
PRIDEⁱ	P38606
ProteomicsDBⁱ	55303

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	523
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000273398; ENSP00000273398; ENSG00000114573 [P38606-1]
GeneIDⁱ	523
KEGGⁱ	hsa:523
UCSCⁱ	uc003eao.4 human [P38606-1]

Organism-specific databases

CTDⁱ	523
DisGeNETⁱ	523
EuPathDBⁱ	HostDB:ENSG00000114573.9
GeneCardsⁱ	ATP6V1A
HGNCⁱ	HGNC:851 ATP6V1A
HPAⁱ	CAB006910 HPA035083 HPA035084
MalaCardsⁱ	ATP6V1A
MIMⁱ	607027 gene 617403 phenotype 618012 phenotype
neXtProtⁱ	NX_P38606
OpenTargetsⁱ	ENSG00000114573
PharmGKBⁱ	PA25152
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1352 Eukaryota COG1155 LUCA
GeneTreeⁱ	ENSGT00550000074787
HOGENOMⁱ	HOG000161057
HOVERGENⁱ	HBG053351
InParanoidⁱ	P38606
KOⁱ	K02145
OMAⁱ	QQLAKWS
OrthoDBⁱ	EOG091G03SR
PhylomeDBⁱ	P38606
TreeFamⁱ	TF300811

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03781-MONOMER
Reactomeⁱ	R-HSA-1222556 ROS, RNS production in phagocytes R-HSA-77387 Insulin receptor recycling R-HSA-917977 Transferrin endocytosis and recycling R-HSA-983712 Ion channel transport

Miscellaneous databases

ChiTaRSⁱ	ATP6V1A human
GeneWikiⁱ	ATP6V1A
GenomeRNAiⁱ	523
Protein Ontology More...PROⁱ	PR:P38606
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114573 Expressed in 238 organ(s), highest expression level in Brodmann (1909) area 23
CleanExⁱ	HS_ATP6V1A
ExpressionAtlasⁱ	P38606 baseline and differential
Genevisibleⁱ	P38606 HS

Family and domain databases

Gene3Dⁱ	1.10.1140.10, 1 hit 2.40.30.20, 1 hit
HAMAPⁱ	MF_00309 ATP_synth_A_arch, 1 hit
InterProⁱ	View protein in InterPro IPR031686 ATP-synth_a_Xtn IPR023366 ATP_synth_asu-like_sf IPR020003 ATPase_a/bsu_AS IPR004100 ATPase_F1/V1/A1_a/bsu_N IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd IPR024034 ATPase_F1/V1_b/a_C IPR005725 ATPase_V1-cplx_asu IPR027417 P-loop_NTPase IPR022878 V-ATPase_asu
PANTHERⁱ	PTHR43607 PTHR43607, 1 hit
Pfamⁱ	View protein in Pfam PF00006 ATP-synt_ab, 1 hit PF02874 ATP-synt_ab_N, 1 hit PF16886 ATP-synt_ab_Xtn, 1 hit
SUPFAMⁱ	SSF50615 SSF50615, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR01042 V-ATPase_V1_A, 1 hit
PROSITEⁱ	View protein in PROSITE PS00152 ATPASE_ALPHA_BETA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VATA_HUMAN
Accessionⁱ	P38606Primary (citable) accession number: P38606 Secondary accession number(s): B2RBR8 , B7Z1R5, D3DN75, Q53YD9, Q96DY6, Q9UHY3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	August 2, 2002
	Last modified:	November 7, 2018
	This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniProtKB - P38606 (VATA_HUMAN)

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V-type proton ATPase catalytic subunit A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ