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Protein

Uroplakin-2

Gene

Upk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-2
Short name:
UP2
Alternative name(s):
Uroplakin II
Short name:
UPII
Gene namesi
Name:Upk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98913 Upk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini85 – 155LumenalSequence analysisAdd BLAST71
Transmembranei156 – 180HelicalSequence analysisAdd BLAST25
Topological domaini181 – 184CytoplasmicSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000002263226 – 84Sequence analysisAdd BLAST59
ChainiPRO_000002263385 – 184Uroplakin-2Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP38575
PRIDEiP38575

PTM databases

PhosphoSitePlusiP38575

Expressioni

Gene expression databases

CleanExiMM_UPK2

Interactioni

Subunit structurei

Interacts with uroplakin-1a (UPK1A).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040481

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8ZD Eukaryota
ENOG4111EC7 LUCA
HOGENOMiHOG000132917
HOVERGENiHBG016837
InParanoidiP38575
PhylomeDBiP38575

Family and domain databases

CDDicd09967 UP_II, 1 hit
InterProiView protein in InterPro
IPR009952 Uroplakin-2
PANTHERiPTHR17573 PTHR17573, 1 hit
PfamiView protein in Pfam
PF07353 Uroplakin_II, 1 hit
PIRSFiPIRSF016439 Uroplakin_II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022112 Uroplakin_II, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P38575-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTLPVQTL PLILILLAVL APGTADFNIS SLSGLLSPAL TESLLIALPP
60 70 80 90 100
CHLTGGNATL MVRRANDSKV VKSDFVVPPC RGRRELVSVV DSGSGYTVTR
110 120 130 140 150
LSAYQVTNLT PGTKYYISYR VQKGTSTESS PETPMSTLPR KNMESIGLGM
160 170 180
ARTGGMVVIT VLLSVAMFLL VVGLIVALHW DARK
Length:184
Mass (Da):19,572
Last modified:October 1, 1994 - v1
Checksum:iE15E00C1EB1A7253
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3SXK0Q3SXK0_MOUSE
Uroplakin-2
Upk2 mCG_10733
184Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08030 mRNA Translation: AAA19602.1
U14421 Genomic DNA Translation: AAC52158.1
CCDSiCCDS23112.1
PIRiA55603 A54135
UniGeneiMm.4453

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08030 mRNA Translation: AAA19602.1
U14421 Genomic DNA Translation: AAC52158.1
CCDSiCCDS23112.1
PIRiA55603 A54135
UniGeneiMm.4453

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040481

PTM databases

PhosphoSitePlusiP38575

Proteomic databases

PaxDbiP38575
PRIDEiP38575

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98913 Upk2

Phylogenomic databases

eggNOGiENOG410J8ZD Eukaryota
ENOG4111EC7 LUCA
HOGENOMiHOG000132917
HOVERGENiHBG016837
InParanoidiP38575
PhylomeDBiP38575

Miscellaneous databases

PROiPR:P38575
SOURCEiSearch...

Gene expression databases

CleanExiMM_UPK2

Family and domain databases

CDDicd09967 UP_II, 1 hit
InterProiView protein in InterPro
IPR009952 Uroplakin-2
PANTHERiPTHR17573 PTHR17573, 1 hit
PfamiView protein in Pfam
PF07353 Uroplakin_II, 1 hit
PIRSFiPIRSF016439 Uroplakin_II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022112 Uroplakin_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPK2_MOUSE
AccessioniPrimary (citable) accession number: P38575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 18, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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