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Protein

Integrin alpha-E

Gene

ITGAE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi522 – 530Sequence analysis9
Calcium bindingi586 – 594Sequence analysis9
Calcium bindingi654 – 662Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-216083 Integrin cell surface interactions
SIGNORiP38570

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-E
Alternative name(s):
HML-1 antigen
Integrin alpha-IEL
Mucosal lymphocyte 1 antigen
CD_antigen: CD103
Cleaved into the following 2 chains:
Gene namesi
Name:ITGAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000083457.11
HGNCiHGNC:6147 ITGAE
MIMi604682 gene
neXtProtiNX_P38570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 1124ExtracellularSequence analysisAdd BLAST1106
Transmembranei1125 – 1147HelicalSequence analysisAdd BLAST23
Topological domaini1148 – 1179CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi208D → A: Loss of E-cadherin binding. 1 Publication1
Mutagenesisi316F → A: Loss of E-cadherin binding. 1 Publication1

Organism-specific databases

DisGeNETi3682
OpenTargetsiENSG00000083457
PharmGKBiPA29947

Polymorphism and mutation databases

BioMutaiITGAE
DMDMi226694184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001628319 – 1179Integrin alpha-EAdd BLAST1161
ChainiPRO_000001628419 – 177Integrin alpha-E light chainAdd BLAST159
ChainiPRO_0000016285179 – 1177Integrin alpha-E heavy chainAdd BLAST999

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi70 ↔ 79By similarity
Disulfide bondi126 ↔ 159By similarity
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi706 ↔ 762By similarity
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi823 ↔ 829By similarity
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi893 ↔ 907By similarity
Glycosylationi934N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi954N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1008 ↔ 1033By similarity
Disulfide bondi1041 ↔ 1057By similarity
Glycosylationi1065N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1096N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP38570
PaxDbiP38570
PeptideAtlasiP38570
PRIDEiP38570
ProteomicsDBi55300

PTM databases

iPTMnetiP38570
PhosphoSitePlusiP38570

Expressioni

Tissue specificityi

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Inductioni

Integrin alpha-E/beta-7 is induced by TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000083457
CleanExiHS_ITGAE
ExpressionAtlasiP38570 baseline and differential
GenevisibleiP38570 HS

Organism-specific databases

HPAiCAB026461
HPA036313

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Protein-protein interaction databases

BioGridi109888, 3 interactors
ComplexPortaliCPX-1824 Integrin alphaE-beta7 complex
CORUMiP38570
IntActiP38570, 1 interactor
STRINGi9606.ENSP00000263087

Structurei

3D structure databases

ProteinModelPortaliP38570
SMRiP38570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 79FG-GAP 1Add BLAST58
Repeati80 – 138FG-GAP 2Add BLAST59
Domaini200 – 389VWFAPROSITE-ProRule annotationAdd BLAST190
Repeati390 – 442FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati447 – 499FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati500 – 560FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati563 – 627FG-GAP 6PROSITE-ProRule annotationAdd BLAST65
Repeati631 – 691FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 199X-domain (extra domain)Add BLAST55

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1150 – 1154GFFKR motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 198Glu-rich (acidic)Add BLAST18

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPAZ Eukaryota
ENOG410XR7I LUCA
GeneTreeiENSGT00760000118782
HOGENOMiHOG000049185
HOVERGENiHBG006187
InParanoidiP38570
KOiK06524
OMAiKMQGVER
OrthoDBiEOG091G09V5
PhylomeDBiP38570
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 4 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 5 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38570-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ
60 70 80 90 100
TWLLVTSPRT KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS
110 120 130 140 150
HHGVLICIQV LVRRPHSLSS ELTGTCSLLG PDLRPQAQAN FFDLENLLDP
160 170 180 190 200
DARVDTGDCY SNKEGGGEDD VNTARQRRAL EKEEEEDKEE EEDEEEEEAG
210 220 230 240 250
TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN FALVQYGGVI
260 270 280 290 300
QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR
310 320 330 340 350
RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART
360 370 380 390 400
ARELNLIASD PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ
410 420 430 440 450
LAQIGFSAQI LDERQVLLGA VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA
460 470 480 490 500
ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA PRYKHHGAVF ELQKEGREAS
510 520 530 540 550
FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH VHGEEGRVYV
560 570 580 590 600
YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP
610 620 630 640 650
LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA
660 670 680 690 700
GGFDISGDGL ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV
710 720 730 740 750
VNVRLCFEIS SVTTASESGL REALLNFTLD VDVGKQRRRL QCSDVRSCLG
760 770 780 790 800
CLREWSSGSQ LCEDLLLMPT EGELCEEDCF SNASVKVSYQ LQTPEGQTDH
810 820 830 840 850
PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS QQELVVGLTK
860 870 880 890 900
ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA
910 920 930 940 950
SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR
960 970 980 990 1000
SLANETHTLQ FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG
1010 1020 1030 1040 1050
AEYQLQICVP TKLRGLQVVA VKKLTRTQAS TVCTWSQERA CAYSSVQHVE
1060 1070 1080 1090 1100
EWHSVSCVIA SDKENVTVAA EISWDHSEEL LKDVTELQIL GEISFNKSLY
1110 1120 1130 1140 1150
EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI VILVILFKCG
1160 1170
FFKRKYQQLN LESIRKAQLK SENLLEEEN
Length:1,179
Mass (Da):130,159
Last modified:April 14, 2009 - v3
Checksum:i6645F8FFF9A0F045
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_008884360D → E. 1
Natural variantiVAR_054889477I → V2 PublicationsCorresponds to variant dbSNP:rs220479Ensembl.1
Natural variantiVAR_054890482R → Q2 PublicationsCorresponds to variant dbSNP:rs2272606Ensembl.1
Natural variantiVAR_020037892Q → H. Corresponds to variant dbSNP:rs3744679Ensembl.1
Natural variantiVAR_034025950R → W1 PublicationCorresponds to variant dbSNP:rs1716Ensembl.1
Natural variantiVAR_0548911019V → A2 PublicationsCorresponds to variant dbSNP:rs2976230Ensembl.1
Natural variantiVAR_0088851041C → S. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25851 mRNA Translation: AAB59359.2
AC116914 Genomic DNA No translation available.
BC113436 mRNA Translation: AAI13437.1
BC117207 mRNA Translation: AAI17208.1
AF168787 Genomic DNA Translation: AAF43107.1
CCDSiCCDS32531.1
PIRiA53213
RefSeqiNP_002199.3, NM_002208.4
UniGeneiHs.513867

Genome annotation databases

EnsembliENST00000263087; ENSP00000263087; ENSG00000083457
GeneIDi3682
KEGGihsa:3682
UCSCiuc002fwo.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiITAE_HUMAN
AccessioniPrimary (citable) accession number: P38570
Secondary accession number(s): Q17RS6, Q9NZU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 14, 2009
Last modified: June 20, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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