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Entry version 175 (23 Feb 2022)
Sequence version 1 (01 Oct 1994)
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Protein

GrpE protein homolog, mitochondrial

Gene

MGE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins and the association of SSC1 with TIM44.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.8.1.1, the mitochondrial protein translocase (mpt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GrpE protein homolog, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGE1
Synonyms:GRPE, GRPE1, YGE1
Ordered Locus Names:YOR232W
ORF Names:O5099
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000005758, MGE1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YOR232W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000013046? – 228GrpE protein homolog, mitochondrial

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38523

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38523

PRoteomics IDEntifications database

More...
PRIDEi
P38523

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38523

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P38523

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PAM complex, at least composed of SSC1 (mtHsp70), MGE1, TIM44, PAM16/TIM16, PAM17 and PAM18/TIM14.

Interacts with SSQ1.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34625, 351 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-539, TIM23 mitochondrial inner membrane pre-sequence translocase complex, motor variant

Database of interacting proteins

More...
DIPi
DIP-775N

Protein interaction database and analysis system

More...
IntActi
P38523, 22 interactors

Molecular INTeraction database

More...
MINTi
P38523

STRING: functional protein association networks

More...
STRINGi
4932.YOR232W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38523, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P38523

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 66DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3003, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005589

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_057217_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38523

Identification of Orthologs from Complete Genome Data

More...
OMAi
YAYEKIA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00446, GrpE, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.22.10, 1 hit
3.90.20.20, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01151, GrpE, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000740, GrpE
IPR013805, GrpE_coiled_coil
IPR009012, GrpE_head

The PANTHER Classification System

More...
PANTHERi
PTHR21237, PTHR21237, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01025, GrpE, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00773, GRPEPROTEIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51064, SSF51064, 1 hit
SSF58014, SSF58014, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01071, GRPE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P38523-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAFSAATVR ATTRKSFIPM APRTPFVTPS FTKNVGSMRR MRFYSDEAKS
60 70 80 90 100
EESKENNEDL TEEQSEIKKL ESQLSAKTKE ASELKDRLLR SVADFRNLQQ
110 120 130 140 150
VTKKDIQKAK DFALQKFAKD LLESVDNFGH ALNAFKEEDL QKSKEISDLY
160 170 180 190 200
TGVRMTRDVF ENTLRKHGIE KLDPLGEPFD PNKHEATFEL PQPDKEPGTV
210 220
FHVQQLGFTL NDRVIRPAKV GIVKGEEN
Length:228
Mass (Da):26,066
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i816A5E26C648E613
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X78350 Genomic DNA Translation: CAA55145.1
D26059 Genomic DNA Translation: BAA05058.1
U09565 Unassigned RNA Translation: AAA19253.1
Z75140 Genomic DNA Translation: CAA99452.1
BK006948 Genomic DNA Translation: DAA11002.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S41760

NCBI Reference Sequences

More...
RefSeqi
NP_014875.3, NM_001183651.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR232W_mRNA; YOR232W; YOR232W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854407

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR232W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78350 Genomic DNA Translation: CAA55145.1
D26059 Genomic DNA Translation: BAA05058.1
U09565 Unassigned RNA Translation: AAA19253.1
Z75140 Genomic DNA Translation: CAA99452.1
BK006948 Genomic DNA Translation: DAA11002.1
PIRiS41760
RefSeqiNP_014875.3, NM_001183651.3

3D structure databases

SMRiP38523
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi34625, 351 interactors
ComplexPortaliCPX-539, TIM23 mitochondrial inner membrane pre-sequence translocase complex, motor variant
DIPiDIP-775N
IntActiP38523, 22 interactors
MINTiP38523
STRINGi4932.YOR232W

Protein family/group databases

TCDBi3.A.8.1.1, the mitochondrial protein translocase (mpt) family

PTM databases

iPTMnetiP38523
MetOSiteiP38523

Proteomic databases

MaxQBiP38523
PaxDbiP38523
PRIDEiP38523

Genome annotation databases

EnsemblFungiiYOR232W_mRNA; YOR232W; YOR232W
GeneIDi854407
KEGGisce:YOR232W

Organism-specific databases

SGDiS000005758, MGE1
VEuPathDBiFungiDB:YOR232W

Phylogenomic databases

eggNOGiKOG3003, Eukaryota
GeneTreeiENSGT00390000005589
HOGENOMiCLU_057217_0_0_1
InParanoidiP38523
OMAiYAYEKIA

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38523
RNActiP38523, protein

Family and domain databases

CDDicd00446, GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151, GrpE, 1 hit
InterProiView protein in InterPro
IPR000740, GrpE
IPR013805, GrpE_coiled_coil
IPR009012, GrpE_head
PANTHERiPTHR21237, PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025, GrpE, 1 hit
PRINTSiPR00773, GRPEPROTEIN
SUPFAMiSSF51064, SSF51064, 1 hit
SSF58014, SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071, GRPE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRPE_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38523
Secondary accession number(s): D6W2T6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 23, 2022
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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