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Protein

C->U-editing enzyme APOBEC-1

Gene

Apobec1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.By similarity

Catalytic activityi

Cytosine(6666) in apolipoprotein B mRNA + H2O = uracil(6666) in apolipoprotein B mRNA + NH3.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Zinc; catalyticBy similarity1
Active sitei63Proton donorBy similarity1
Metal bindingi93Zinc; catalyticBy similarity1
Metal bindingi96Zinc; catalyticBy similarity1

GO - Molecular functioni

  • AU-rich element binding Source: Ensembl
  • cytidine deaminase activity Source: MGI
  • cytosine deaminase activity Source: RGD
  • enzyme activator activity Source: RGD
  • mRNA binding Source: RGD
  • protein domain specific binding Source: RGD
  • ribonucleoprotein complex binding Source: RGD
  • RNA binding Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.5.4.36 5301
ReactomeiR-RNO-72200 mRNA Editing: C to U Conversion
R-RNO-75094 Formation of the Editosome

Names & Taxonomyi

Protein namesi
Recommended name:
C->U-editing enzyme APOBEC-1 (EC:3.5.4.36)
Alternative name(s):
Apolipoprotein B mRNA-editing enzyme 1
mRNA(cytosine(6666)) deaminase 1
Gene namesi
Name:Apobec1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2133 Apobec1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717481 – 229C->U-editing enzyme APOBEC-1Add BLAST229

Proteomic databases

PaxDbiP38483
PRIDEiP38483

PTM databases

PhosphoSitePlusiP38483

Expressioni

Tissue specificityi

Expressed in the liver as well as small intestine.

Gene expression databases

BgeeiENSRNOG00000015411 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiP38483 RN

Interactioni

Subunit structurei

Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Interacts with SYNCRIP. Interacts with HNRPAB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP38483
STRINGi10116.ENSRNOP00000020735

Structurei

3D structure databases

ProteinModelPortaliP38483
SMRiP38483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 134CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST125

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi180 – 193Leu-richAdd BLAST14

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKDF Eukaryota
ENOG4111BJA LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033766
HOVERGENiHBG050445
InParanoidiP38483
KOiK16932
OMAiNFVNYPP
OrthoDBiEOG091G0PT8
PhylomeDBiP38483
TreeFamiTF331356

Family and domain databases

InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38483-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSETGPVAV DPTLRRRIEP HEFEVFFDPR ELRKETCLLY EINWGGRHSI
60 70 80 90 100
WRHTSQNTNK HVEVNFIEKF TTERYFCPNT RCSITWFLSW SPCGECSRAI
110 120 130 140 150
TEFLSRYPHV TLFIYIARLY HHADPRNRQG LRDLISSGVT IQIMTEQESG
160 170 180 190 200
YCWRNFVNYS PSNEAHWPRY PHLWVRLYVL ELYCIILGLP PCLNILRRKQ
210 220
PQLTFFTIAL QSCHYQRLPP HILWATGLK
Length:229
Mass (Da):27,274
Last modified:October 1, 1994 - v1
Checksum:i08766441882789B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07114 mRNA Translation: AAA17394.1
BC085335 mRNA Translation: AAH85335.1
PIRiI59577
RefSeqiNP_037039.1, NM_012907.2
XP_006237352.1, XM_006237290.2
XP_006237353.1, XM_006237291.2
XP_006237354.1, XM_006237292.2
XP_006237355.1, XM_006237293.2
XP_017447973.1, XM_017592484.1
UniGeneiRn.10002

Genome annotation databases

EnsembliENSRNOT00000020735; ENSRNOP00000020735; ENSRNOG00000015411
GeneIDi25383
KEGGirno:25383
UCSCiRGD:2133 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07114 mRNA Translation: AAA17394.1
BC085335 mRNA Translation: AAH85335.1
PIRiI59577
RefSeqiNP_037039.1, NM_012907.2
XP_006237352.1, XM_006237290.2
XP_006237353.1, XM_006237291.2
XP_006237354.1, XM_006237292.2
XP_006237355.1, XM_006237293.2
XP_017447973.1, XM_017592484.1
UniGeneiRn.10002

3D structure databases

ProteinModelPortaliP38483
SMRiP38483
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP38483
STRINGi10116.ENSRNOP00000020735

PTM databases

PhosphoSitePlusiP38483

Proteomic databases

PaxDbiP38483
PRIDEiP38483

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020735; ENSRNOP00000020735; ENSRNOG00000015411
GeneIDi25383
KEGGirno:25383
UCSCiRGD:2133 rat

Organism-specific databases

CTDi339
RGDi2133 Apobec1

Phylogenomic databases

eggNOGiENOG410IKDF Eukaryota
ENOG4111BJA LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033766
HOVERGENiHBG050445
InParanoidiP38483
KOiK16932
OMAiNFVNYPP
OrthoDBiEOG091G0PT8
PhylomeDBiP38483
TreeFamiTF331356

Enzyme and pathway databases

BRENDAi3.5.4.36 5301
ReactomeiR-RNO-72200 mRNA Editing: C to U Conversion
R-RNO-75094 Formation of the Editosome

Miscellaneous databases

PROiPR:P38483

Gene expression databases

BgeeiENSRNOG00000015411 Expressed in 10 organ(s), highest expression level in spleen
GenevisibleiP38483 RN

Family and domain databases

InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABEC1_RAT
AccessioniPrimary (citable) accession number: P38483
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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