UniProtKB - P38432 (COIL_HUMAN)
Coilin
COIL
Functioni
Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.
1 PublicationGO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
- U1 snRNA binding Source: GO_Central
- U2 snRNA binding Source: GO_Central
GO - Biological processi
- spliceosomal snRNP assembly Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | P38432 |
SignaLinki | P38432 |
SIGNORi | P38432 |
Names & Taxonomyi
Protein namesi | Recommended name: CoilinAlternative name(s): p80-coilin |
Gene namesi | Name:COIL Synonyms:CLN80 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2184, COIL |
MIMi | 600272, gene |
neXtProti | NX_P38432 |
VEuPathDBi | HostDB:ENSG00000121058 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- Cajal body 3 Publications
Nucleus
- Cajal body Source: UniProtKB
- fibrillar center Source: HPA
- nuclear body Source: HPA
- nucleolus Source: UniProtKB
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 413 – 419 | RGRGRGR → GGGGGGG: Impaired interaction with SMN. 1 Publication | 7 |
Organism-specific databases
DisGeNETi | 8161 |
OpenTargetsi | ENSG00000121058 |
PharmGKBi | PA26700 |
Miscellaneous databases
Pharosi | P38432, Tbio |
Genetic variation databases
BioMutai | COIL |
DMDMi | 585632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058146 | 1 – 576 | CoilinAdd BLAST | 576 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 105 | PhosphoserineCombined sources | 1 | |
Modified residuei | 122 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 127 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 151 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 160 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 184 | Phosphoserine; by VRK1 and VRK21 Publication | 1 | |
Cross-linki | 204 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 209 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 248 | PhosphoserineBy similarity | 1 | |
Modified residuei | 250 | PhosphoserineBy similarity | 1 | |
Modified residuei | 256 | PhosphoserineBy similarity | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 272 | PhosphoserineCombined sources | 1 | |
Cross-linki | 274 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 281 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 290 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 293 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 301 | PhosphoserineCombined sources | 1 | |
Modified residuei | 303 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 403 | PhosphoserineCombined sources | 1 | |
Cross-linki | 444 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 456 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 487 | PhosphoserineCombined sources | 1 | |
Modified residuei | 489 | PhosphoserineCombined sources | 1 | |
Cross-linki | 496 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 566 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P38432 |
jPOSTi | P38432 |
MassIVEi | P38432 |
MaxQBi | P38432 |
PaxDbi | P38432 |
PeptideAtlasi | P38432 |
PRIDEi | P38432 |
ProteomicsDBi | 55295 |
PTM databases
GlyGeni | P38432, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P38432 |
PhosphoSitePlusi | P38432 |
SwissPalmi | P38432 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000121058, Expressed in sperm and 244 other tissues |
ExpressionAtlasi | P38432, baseline and differential |
Genevisiblei | P38432, HS |
Organism-specific databases
HPAi | ENSG00000121058, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with ANKS1B (PubMed:15862129).
Interacts with SMN1 (via Tudor domain) (PubMed:11641277).
Interacts (via C-terminus) with AK6 (PubMed:16079131).
Interacts with WRAP53/TCAB1 (PubMed:21072240).
Interacts with HMBOX1 (PubMed:23685356).
Interacts with PSME3; the interaction is inhibited by PSME3IP1 (PubMed:29934401).
6 PublicationsBinary interactionsi
P38432
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113815, 544 interactors |
CORUMi | P38432 |
DIPi | DIP-38503N |
IntActi | P38432, 110 interactors |
MINTi | P38432 |
STRINGi | 9606.ENSP00000240316 |
Miscellaneous databases
RNActi | P38432, protein |
Structurei
3D structure databases
AlphaFoldDBi | P38432 |
BMRBi | P38432 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 223 – 226 | 1-1 | 4 | |
Repeati | 268 – 271 | 1-2 | 4 | |
Repeati | 386 – 389 | 2-1 | 4 | |
Repeati | 413 – 414 | 3-1 | 2 | |
Repeati | 415 – 416 | 3-2 | 2 | |
Repeati | 417 – 418 | 3-3 | 2 | |
Repeati | 419 – 420 | 3-4 | 2 | |
Domaini | 460 – 559 | Tudor; atypicalAdd BLAST | 100 | |
Repeati | 517 – 520 | 2-2 | 4 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 125 – 330 | DisorderedSequence analysisAdd BLAST | 206 | |
Regioni | 223 – 271 | 2 X 4 AA repeats of A-R-N-SAdd BLAST | 49 | |
Regioni | 352 – 389 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 386 – 520 | 2 X 4 AA repeats of S-L-P-AAdd BLAST | 135 | |
Regioni | 392 – 420 | Required for interaction with SMN1 PublicationAdd BLAST | 29 | |
Regioni | 413 – 420 | 4 X 2 AA tandem repeats of R-G | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 125 – 186 | Basic and acidic residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 238 – 273 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 274 – 288 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 303 – 330 | Polar residuesSequence analysisAdd BLAST | 28 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QVWV, Eukaryota |
GeneTreei | ENSGT00390000004832 |
HOGENOMi | CLU_034553_0_0_1 |
InParanoidi | P38432 |
OMAi | RKITVFW |
OrthoDBi | 1068620at2759 |
PhylomeDBi | P38432 |
TreeFami | TF331811 |
Family and domain databases
InterProi | View protein in InterPro IPR024822, Coilin IPR031722, Coilin_N |
PANTHERi | PTHR15197, PTHR15197, 1 hit |
Pfami | View protein in Pfam PF15862, Coilin_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG
60 70 80 90 100
FSSGAFLGLY LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG
110 120 130 140 150
DINLSLRKAK KRAFQLEEGE ETEPDCKYSK KHWKSRENNN NNEKVLDLEP
160 170 180 190 200
KAVTDQTVSK KNKRKNKATC GTVGDDNEEA KRKSPKKKEK CEYKKKAKNP
210 220 230 240 250
KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS KESPSSSSES
260 270 280 290 300
ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF
310 320 330 340 350
SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR
360 370 380 390 400
GRPGPGLSSQ TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN
410 420 430 440 450
LFSWKGAKGR GMRGRGRGRG HPVSCVVNRS TDNQRQQQLN DVVKNSSTII
460 470 480 490 500
QNPVETPKKD YSLLPLLAAA PQVGEKIAFK LLELTSSYSP DVSDYKEGRI
510 520 530 540 550
LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV EYAVTQESKI
560 570
TVFWKELIDP RLIIESPSNT SSTEPA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI3L369 | I3L369_HUMAN | Coilin | COIL | 37 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58411 mRNA Translation: AAA36412.1 AK313616 mRNA Translation: BAG36378.1 AC004584 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94522.1 BC010385 mRNA Translation: AAH10385.1 U06632 mRNA Translation: AAB81550.1 |
CCDSi | CCDS11592.1 |
PIRi | S50113 |
RefSeqi | NP_004636.1, NM_004645.2 |
Genome annotation databases
Ensembli | ENST00000240316.5; ENSP00000240316.4; ENSG00000121058.5 |
GeneIDi | 8161 |
KEGGi | hsa:8161 |
MANE-Selecti | ENST00000240316.5; ENSP00000240316.4; NM_004645.3; NP_004636.1 |
UCSCi | uc002iuu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58411 mRNA Translation: AAA36412.1 AK313616 mRNA Translation: BAG36378.1 AC004584 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94522.1 BC010385 mRNA Translation: AAH10385.1 U06632 mRNA Translation: AAB81550.1 |
CCDSi | CCDS11592.1 |
PIRi | S50113 |
RefSeqi | NP_004636.1, NM_004645.2 |
3D structure databases
AlphaFoldDBi | P38432 |
BMRBi | P38432 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113815, 544 interactors |
CORUMi | P38432 |
DIPi | DIP-38503N |
IntActi | P38432, 110 interactors |
MINTi | P38432 |
STRINGi | 9606.ENSP00000240316 |
PTM databases
GlyGeni | P38432, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P38432 |
PhosphoSitePlusi | P38432 |
SwissPalmi | P38432 |
Genetic variation databases
BioMutai | COIL |
DMDMi | 585632 |
Proteomic databases
EPDi | P38432 |
jPOSTi | P38432 |
MassIVEi | P38432 |
MaxQBi | P38432 |
PaxDbi | P38432 |
PeptideAtlasi | P38432 |
PRIDEi | P38432 |
ProteomicsDBi | 55295 |
Protocols and materials databases
Antibodypediai | 4307, 323 antibodies from 37 providers |
DNASUi | 8161 |
Genome annotation databases
Ensembli | ENST00000240316.5; ENSP00000240316.4; ENSG00000121058.5 |
GeneIDi | 8161 |
KEGGi | hsa:8161 |
MANE-Selecti | ENST00000240316.5; ENSP00000240316.4; NM_004645.3; NP_004636.1 |
UCSCi | uc002iuu.4, human |
Organism-specific databases
CTDi | 8161 |
DisGeNETi | 8161 |
GeneCardsi | COIL |
HGNCi | HGNC:2184, COIL |
HPAi | ENSG00000121058, Tissue enriched (testis) |
MIMi | 600272, gene |
neXtProti | NX_P38432 |
OpenTargetsi | ENSG00000121058 |
PharmGKBi | PA26700 |
VEuPathDBi | HostDB:ENSG00000121058 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVWV, Eukaryota |
GeneTreei | ENSGT00390000004832 |
HOGENOMi | CLU_034553_0_0_1 |
InParanoidi | P38432 |
OMAi | RKITVFW |
OrthoDBi | 1068620at2759 |
PhylomeDBi | P38432 |
TreeFami | TF331811 |
Enzyme and pathway databases
PathwayCommonsi | P38432 |
SignaLinki | P38432 |
SIGNORi | P38432 |
Miscellaneous databases
BioGRID-ORCSi | 8161, 108 hits in 1077 CRISPR screens |
ChiTaRSi | COIL, human |
GeneWikii | Coilin |
GenomeRNAii | 8161 |
Pharosi | P38432, Tbio |
PROi | PR:P38432 |
RNActi | P38432, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121058, Expressed in sperm and 244 other tissues |
ExpressionAtlasi | P38432, baseline and differential |
Genevisiblei | P38432, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024822, Coilin IPR031722, Coilin_N |
PANTHERi | PTHR15197, PTHR15197, 1 hit |
Pfami | View protein in Pfam PF15862, Coilin_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COIL_HUMAN | |
Accessioni | P38432Primary (citable) accession number: P38432 Secondary accession number(s): B2R931 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families