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UniProtKB - P38432 (COIL_HUMAN)

Entry version 188 (25 May 2022)
Sequence version 1 (01 Oct 1994)
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Protein

Coilin

Gene

COIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P38432

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P38432

SIGNOR Signaling Network Open Resource

More...SIGNORi		P38432

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coilin
Alternative name(s):
p80-coilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COIL
Synonyms:CLN80
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2184, COIL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600272, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P38432

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000121058

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi413 – 419RGRGRGR → GGGGGGG: Impaired interaction with SMN. 1 Publication7

Organism-specific databases

DisGeNET

More...DisGeNETi		8161

Open Targets

More...OpenTargetsi		ENSG00000121058

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26700

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P38432, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COIL

Domain mapping of disease mutations (DMDM)

More...DMDMi		585632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000581461 – 576CoilinAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105PhosphoserineCombined sources1
Modified residuei122PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei184Phosphoserine; by VRK1 and VRK21 Publication1
Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei271PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei290PhosphothreonineCombined sources1
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei301PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei456PhosphothreonineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei566PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.
Phosphorylation during mitosis is associated with disassembly of CBs.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P38432

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P38432

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P38432

MaxQB - The MaxQuant DataBase

More...MaxQBi		P38432

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P38432

PeptideAtlas

More...PeptideAtlasi		P38432

PRoteomics IDEntifications database

More...PRIDEi		P38432

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55295

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P38432, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P38432

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P38432

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P38432

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in all the cell types examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121058, Expressed in sperm and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P38432, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P38432, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121058, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ANKS1B (PubMed:15862129).

Interacts with SMN1 (via Tudor domain) (PubMed:11641277).

Interacts (via C-terminus) with AK6 (PubMed:16079131).

Interacts with WRAP53/TCAB1 (PubMed:21072240).

Interacts with HMBOX1 (PubMed:23685356).

Interacts with PSME3; the interaction is inhibited by PSME3IP1 (PubMed:29934401).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P38432
With#Exp.IntAct
ADAMTS12 - isoform 3 [P58397-3]3EBI-945751,EBI-12048761
AK6 [Q9Y3D8]5EBI-945751,EBI-2896123
ANKS1B - isoform 1 [Q7Z6G8-1]3EBI-945751,EBI-20771343
ANKS1B - isoform 2 [Q7Z6G8-2]3EBI-945751,EBI-20771303
ARMCX1 [Q9P291]3EBI-945751,EBI-2843626
ATXN1 [P54253]9EBI-945751,EBI-930964
ATXN1 - isoform 1 [P54253-1]6EBI-945751,EBI-930975
BYSL [Q13895]11EBI-945751,EBI-358049
C9orf72 [Q96LT7]3EBI-945751,EBI-2961725
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-945751,EBI-10961624
CDC23 [Q9UJX2]3EBI-945751,EBI-396137
CEP70 [Q8NHQ1]3EBI-945751,EBI-739624
itself3EBI-945751,EBI-945751
DRG1 [Q9Y295]3EBI-945751,EBI-719554
DYNC2I2 [Q96EX3]3EBI-945751,EBI-2556091
FGF12 [P61328]3EBI-945751,EBI-6657662
hCG_1987119 [A0A024R8L2]3EBI-945751,EBI-14103818
HSF2BP [O75031]3EBI-945751,EBI-7116203
KDM1A [O60341]3EBI-945751,EBI-710124
LNX1 [Q8TBB1]2EBI-945751,EBI-739832
MCRS1 [Q96EZ8]3EBI-945751,EBI-348259
MFAP1 [P55081]3EBI-945751,EBI-1048159
NFU1 [Q9UMS0]3EBI-945751,EBI-725252
NKAPD1 [Q6ZUT1]3EBI-945751,EBI-3920396
NTAQ1 [Q96HA8]3EBI-945751,EBI-741158
PDE4D [Q08499]3EBI-945751,EBI-1642831
PDE4D - isoform 6 [Q08499-8]3EBI-945751,EBI-9090666
PDLIM5 [Q96HC4]4EBI-945751,EBI-751267
PICK1 [Q9NRD5]3EBI-945751,EBI-79165
PLOD3 [O60568]3EBI-945751,EBI-741582
POLR2L [P62875]3EBI-945751,EBI-359527
POLR3C [Q9BUI4]3EBI-945751,EBI-5452779
PSME3 [P61289]6EBI-945751,EBI-355546
PTS [Q03393]3EBI-945751,EBI-712344
SMN2 [Q16637]4EBI-945751,EBI-395421
SNRPF [P62306]6EBI-945751,EBI-356900
SPANXN2 [Q5MJ10]3EBI-945751,EBI-12023934
SRPK2 [P78362]3EBI-945751,EBI-593303
VRK1 [Q99986]9EBI-945751,EBI-1769146
WRAP53 [Q9BUR4]4EBI-945751,EBI-2563542
XRCC5 [P13010]6EBI-945751,EBI-357997
XRCC6 [P12956]3EBI-945751,EBI-353208
ZCCHC10 [Q8TBK6]3EBI-945751,EBI-597063
ZNF277 [G5E9M4]3EBI-945751,EBI-11995620
ZNF277 [Q8WWA6]3EBI-945751,EBI-10192794

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113815, 544 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P38432

Database of interacting proteins

More...DIPi		DIP-38503N

Protein interaction database and analysis system

More...IntActi		P38432, 110 interactors

Molecular INTeraction database

More...MINTi		P38432

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000240316

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P38432, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P38432

Biological Magnetic Resonance Data Bank

More...BMRBi		P38432

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati223 – 2261-14
Repeati268 – 2711-24
Repeati386 – 3892-14
Repeati413 – 4143-12
Repeati415 – 4163-22
Repeati417 – 4183-32
Repeati419 – 4203-42
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini460 – 559Tudor; atypicalAdd BLAST100
Repeati517 – 5202-24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni125 – 330DisorderedSequence analysisAdd BLAST206
Regioni223 – 2712 X 4 AA repeats of A-R-N-SAdd BLAST49
Regioni352 – 389DisorderedSequence analysisAdd BLAST38
Regioni386 – 5202 X 4 AA repeats of S-L-P-AAdd BLAST135
Regioni392 – 420Required for interaction with SMN1 PublicationAdd BLAST29
Regioni413 – 4204 X 2 AA tandem repeats of R-G8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 186Basic and acidic residuesSequence analysisAdd BLAST62
Compositional biasi238 – 273Polar residuesSequence analysisAdd BLAST36
Compositional biasi274 – 288Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi303 – 330Polar residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coilin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVWV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004832

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034553_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P38432

Identification of Orthologs from Complete Genome Data

More...OMAi		RKITVFW

Database of Orthologous Groups

More...OrthoDBi		1068620at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P38432

TreeFam database of animal gene trees

More...TreeFami		TF331811

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024822, Coilin
IPR031722, Coilin_N

The PANTHER Classification System

More...PANTHERi		PTHR15197, PTHR15197, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15862, Coilin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P38432-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG 
        60         70         80         90        100
FSSGAFLGLY LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG 
       110        120        130        140        150
DINLSLRKAK KRAFQLEEGE ETEPDCKYSK KHWKSRENNN NNEKVLDLEP 
       160        170        180        190        200
KAVTDQTVSK KNKRKNKATC GTVGDDNEEA KRKSPKKKEK CEYKKKAKNP 
       210        220        230        240        250
KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS KESPSSSSES 
       260        270        280        290        300
ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF 
       310        320        330        340        350
SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR 
       360        370        380        390        400
GRPGPGLSSQ TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN 
       410        420        430        440        450
LFSWKGAKGR GMRGRGRGRG HPVSCVVNRS TDNQRQQQLN DVVKNSSTII 
       460        470        480        490        500
QNPVETPKKD YSLLPLLAAA PQVGEKIAFK LLELTSSYSP DVSDYKEGRI 
       510        520        530        540        550
LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV EYAVTQESKI 
       560        570 
TVFWKELIDP RLIIESPSNT SSTEPA
Length:576
Mass (Da):62,608
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i879702B590F16849
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L369I3L369_HUMAN
Coilin
COIL
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M58411 mRNA Translation: AAA36412.1
AK313616 mRNA Translation: BAG36378.1
AC004584 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94522.1
BC010385 mRNA Translation: AAH10385.1
U06632 mRNA Translation: AAB81550.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11592.1

Protein sequence database of the Protein Information Resource

More...PIRi		S50113

NCBI Reference Sequences

More...RefSeqi		NP_004636.1, NM_004645.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000240316.5; ENSP00000240316.4; ENSG00000121058.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8161

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8161

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000240316.5; ENSP00000240316.4; NM_004645.3; NP_004636.1

UCSC genome browser

More...UCSCi		uc002iuu.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58411 mRNA Translation: AAA36412.1
AK313616 mRNA Translation: BAG36378.1
AC004584 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94522.1
BC010385 mRNA Translation: AAH10385.1
U06632 mRNA Translation: AAB81550.1
CCDSiCCDS11592.1
PIRiS50113
RefSeqiNP_004636.1, NM_004645.2

3D structure databases

AlphaFoldDBiP38432
BMRBiP38432
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi113815, 544 interactors
CORUMiP38432
DIPiDIP-38503N
IntActiP38432, 110 interactors
MINTiP38432
STRINGi9606.ENSP00000240316

PTM databases

GlyGeniP38432, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP38432
PhosphoSitePlusiP38432
SwissPalmiP38432

Genetic variation databases

BioMutaiCOIL
DMDMi585632

Proteomic databases

EPDiP38432
jPOSTiP38432
MassIVEiP38432
MaxQBiP38432
PaxDbiP38432
PeptideAtlasiP38432
PRIDEiP38432
ProteomicsDBi55295

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4307, 323 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		8161

Genome annotation databases

EnsembliENST00000240316.5; ENSP00000240316.4; ENSG00000121058.5
GeneIDi8161
KEGGihsa:8161
MANE-SelectiENST00000240316.5; ENSP00000240316.4; NM_004645.3; NP_004636.1
UCSCiuc002iuu.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8161
DisGeNETi8161

GeneCards: human genes, protein and diseases

More...GeneCardsi		COIL
HGNCiHGNC:2184, COIL
HPAiENSG00000121058, Tissue enriched (testis)
MIMi600272, gene
neXtProtiNX_P38432
OpenTargetsiENSG00000121058
PharmGKBiPA26700
VEuPathDBiHostDB:ENSG00000121058

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVWV, Eukaryota
GeneTreeiENSGT00390000004832
HOGENOMiCLU_034553_0_0_1
InParanoidiP38432
OMAiRKITVFW
OrthoDBi1068620at2759
PhylomeDBiP38432
TreeFamiTF331811

Enzyme and pathway databases

PathwayCommonsiP38432
SignaLinkiP38432
SIGNORiP38432

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8161, 108 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COIL, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Coilin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8161
PharosiP38432, Tbio

Protein Ontology

More...PROi		PR:P38432
RNActiP38432, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000121058, Expressed in sperm and 244 other tissues
ExpressionAtlasiP38432, baseline and differential
GenevisibleiP38432, HS

Family and domain databases

InterProiView protein in InterPro
IPR024822, Coilin
IPR031722, Coilin_N
PANTHERiPTHR15197, PTHR15197, 1 hit
PfamiView protein in Pfam
PF15862, Coilin_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOIL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38432
Secondary accession number(s): B2R931
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 25, 2022
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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