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Protein

Coilin

Gene

COIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein C-terminus binding Source: UniProtKB

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
P38432

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coilin
Alternative name(s):
p80-coilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COIL
Synonyms:CLN80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000121058.4

Human Gene Nomenclature Database

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HGNCi
HGNC:2184 COIL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600272 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P38432

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi413 – 419RGRGRGR → GGGGGGG: Impaired interaction with SMN. 1 Publication7

Organism-specific databases

DisGeNET

More...
DisGeNETi
8161

Open Targets

More...
OpenTargetsi
ENSG00000121058

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26700

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COIL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
585632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000581461 – 576CoilinAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105PhosphoserineCombined sources1
Modified residuei122PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei184Phosphoserine; by VRK1 and VRK21 Publication1
Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei271PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei290PhosphothreonineCombined sources1
Cross-linki293Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei301PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei456PhosphothreonineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Cross-linki496Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei566PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.
Phosphorylation during mitosis is associated with disassembly of CBs.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P38432

MaxQB - The MaxQuant DataBase

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MaxQBi
P38432

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P38432

PeptideAtlas

More...
PeptideAtlasi
P38432

PRoteomics IDEntifications database

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PRIDEi
P38432

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55295

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38432

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P38432

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P38432

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in all the cell types examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121058 Expressed in 232 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_COIL

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P38432 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P38432 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017524
CAB069400
HPA027885
HPA068537

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ANKS1B (PubMed:15862129). Interacts with SMN1 (via Tudor domain) (PubMed:11641277). Interacts (via C-terminus) with AK6 (PubMed:16079131). Interacts with WRAP53/TCAB1 (PubMed:21072240). Interacts with HMBOX1 (PubMed:23685356). Interacts with PSME3; the interaction is inhibited by FAM192A (PubMed:29934401).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113815, 103 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P38432

Database of interacting proteins

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DIPi
DIP-38503N

Protein interaction database and analysis system

More...
IntActi
P38432, 101 interactors

Molecular INTeraction database

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MINTi
P38432

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000240316

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P38432

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati223 – 2261-14
Repeati268 – 2711-24
Repeati386 – 3892-14
Repeati413 – 4143-12
Repeati415 – 4163-22
Repeati417 – 4183-32
Repeati419 – 4203-42
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini460 – 559Tudor; atypicalAdd BLAST100
Repeati517 – 5202-24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni223 – 2712 X 4 AA repeats of A-R-N-SAdd BLAST49
Regioni386 – 5202 X 4 AA repeats of S-L-P-AAdd BLAST135
Regioni392 – 420Required for interaction with SMN1 PublicationAdd BLAST29
Regioni413 – 4204 X 2 AA tandem repeats of R-G8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi181 – 201Lys-rich (basic)Add BLAST21
Compositional biasi243 – 252Ser/Thr-rich10
Compositional biasi310 – 320Ser/Thr-richAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coilin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHAK Eukaryota
ENOG41121C6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000004832

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000059586

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007989

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P38432

KEGG Orthology (KO)

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KOi
K13150

Identification of Orthologs from Complete Genome Data

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OMAi
HCTVFWL

Database of Orthologous Groups

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OrthoDBi
EOG091G0B3V

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P38432

TreeFam database of animal gene trees

More...
TreeFami
TF331811

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024822 Coilin
IPR031722 Coilin_N

The PANTHER Classification System

More...
PANTHERi
PTHR15197 PTHR15197, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15862 Coilin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P38432-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG
60 70 80 90 100
FSSGAFLGLY LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG
110 120 130 140 150
DINLSLRKAK KRAFQLEEGE ETEPDCKYSK KHWKSRENNN NNEKVLDLEP
160 170 180 190 200
KAVTDQTVSK KNKRKNKATC GTVGDDNEEA KRKSPKKKEK CEYKKKAKNP
210 220 230 240 250
KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS KESPSSSSES
260 270 280 290 300
ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF
310 320 330 340 350
SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR
360 370 380 390 400
GRPGPGLSSQ TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN
410 420 430 440 450
LFSWKGAKGR GMRGRGRGRG HPVSCVVNRS TDNQRQQQLN DVVKNSSTII
460 470 480 490 500
QNPVETPKKD YSLLPLLAAA PQVGEKIAFK LLELTSSYSP DVSDYKEGRI
510 520 530 540 550
LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV EYAVTQESKI
560 570
TVFWKELIDP RLIIESPSNT SSTEPA
Length:576
Mass (Da):62,608
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i879702B590F16849
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L369I3L369_HUMAN
Coilin
COIL
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M58411 mRNA Translation: AAA36412.1
AK313616 mRNA Translation: BAG36378.1
AC004584 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94522.1
BC010385 mRNA Translation: AAH10385.1
U06632 mRNA Translation: AAB81550.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11592.1

Protein sequence database of the Protein Information Resource

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PIRi
S50113

NCBI Reference Sequences

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RefSeqi
NP_004636.1, NM_004645.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.532795

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000240316; ENSP00000240316; ENSG00000121058

Database of genes from NCBI RefSeq genomes

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GeneIDi
8161

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8161

UCSC genome browser

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UCSCi
uc002iuu.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58411 mRNA Translation: AAA36412.1
AK313616 mRNA Translation: BAG36378.1
AC004584 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94522.1
BC010385 mRNA Translation: AAH10385.1
U06632 mRNA Translation: AAB81550.1
CCDSiCCDS11592.1
PIRiS50113
RefSeqiNP_004636.1, NM_004645.2
UniGeneiHs.532795

3D structure databases

ProteinModelPortaliP38432
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113815, 103 interactors
CORUMiP38432
DIPiDIP-38503N
IntActiP38432, 101 interactors
MINTiP38432
STRINGi9606.ENSP00000240316

PTM databases

iPTMnetiP38432
PhosphoSitePlusiP38432
SwissPalmiP38432

Polymorphism and mutation databases

BioMutaiCOIL
DMDMi585632

Proteomic databases

EPDiP38432
MaxQBiP38432
PaxDbiP38432
PeptideAtlasiP38432
PRIDEiP38432
ProteomicsDBi55295

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8161
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240316; ENSP00000240316; ENSG00000121058
GeneIDi8161
KEGGihsa:8161
UCSCiuc002iuu.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8161
DisGeNETi8161
EuPathDBiHostDB:ENSG00000121058.4

GeneCards: human genes, protein and diseases

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GeneCardsi
COIL
HGNCiHGNC:2184 COIL
HPAiCAB017524
CAB069400
HPA027885
HPA068537
MIMi600272 gene
neXtProtiNX_P38432
OpenTargetsiENSG00000121058
PharmGKBiPA26700

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHAK Eukaryota
ENOG41121C6 LUCA
GeneTreeiENSGT00390000004832
HOGENOMiHOG000059586
HOVERGENiHBG007989
InParanoidiP38432
KOiK13150
OMAiHCTVFWL
OrthoDBiEOG091G0B3V
PhylomeDBiP38432
TreeFamiTF331811

Enzyme and pathway databases

SIGNORiP38432

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
COIL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Coilin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8161

Protein Ontology

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PROi
PR:P38432

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000121058 Expressed in 232 organ(s), highest expression level in sperm
CleanExiHS_COIL
ExpressionAtlasiP38432 baseline and differential
GenevisibleiP38432 HS

Family and domain databases

InterProiView protein in InterPro
IPR024822 Coilin
IPR031722 Coilin_N
PANTHERiPTHR15197 PTHR15197, 1 hit
PfamiView protein in Pfam
PF15862 Coilin_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOIL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38432
Secondary accession number(s): B2R931
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 5, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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