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UniProtKB - P38429 (SAP30_YEAST)
Protein
Transcriptional regulatory protein SAP30
Gene
SAP30
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
2 PublicationsMiscellaneous
Present with 704 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- transcription coregulator activity Source: GO_Central
- transcription corepressor activity Source: SGD
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- negative regulation of ribosomal DNA heterochromatin assembly Source: SGD
- negative regulation of silent mating-type cassette heterochromatin assembly Source: SGD
- negative regulation of transcription by RNA polymerase I Source: SGD
- positive regulation of invasive growth in response to glucose limitation Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SCE-3214815, HDACs deacetylate histones |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulatory protein SAP30 |
Gene namesi | Name:SAP30 Ordered Locus Names:YMR263W ORF Names:YM8156.05 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004876, SAP30 |
VEuPathDBi | FungiDB:YMR263W |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- histone deacetylase complex Source: GO_Central
- Rpd3L complex Source: SGD
- Rpd3L-Expanded complex Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203345 | 1 – 201 | Transcriptional regulatory protein SAP30Add BLAST | 201 |
Proteomic databases
MaxQBi | P38429 |
PaxDbi | P38429 |
PRIDEi | P38429 |
Interactioni
Subunit structurei
Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 35441, 608 interactors |
ComplexPortali | CPX-1852, RPD3L histone deacetylase complex |
DIPi | DIP-3846N |
IntActi | P38429, 16 interactors |
MINTi | P38429 |
STRINGi | 4932.YMR263W |
Miscellaneous databases
RNActi | P38429, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 70 | DisorderedSequence analysisAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the SAP30 family.Curated
Phylogenomic databases
eggNOGi | ENOG502RZ9X, Eukaryota |
HOGENOMi | CLU_106811_0_0_1 |
InParanoidi | P38429 |
OMAi | THITNNH |
Family and domain databases
Gene3Di | 6.10.160.20, 1 hit |
InterProi | View protein in InterPro IPR024145, His_deAcase_SAP30/SAP30L IPR038291, SAP30_C_sf IPR025718, SAP30_Sin3-bd |
PANTHERi | PTHR13286, PTHR13286, 1 hit |
Pfami | View protein in Pfam PF13867, SAP30_Sin3_bdg, 1 hit |
i Sequence
Sequence statusi: Complete.
P38429-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARPVNTNAE TESRGRPTQG GGYASNNNGS CNNNNGSNNN NNNNNNNNNN
60 70 80 90 100
SNNSNNNNGP TSSGRTNGKQ RLTAAQQQYI KNLIETHITD NHPDLRPKSH
110 120 130 140 150
PMDFEEYTDA FLRRYKDHFQ LDVPDNLTLQ GYLLGSKLGA KTYSYKRNTQ
160 170 180 190 200
GQHDKRIHKR DLANVVRRHF DEHSIKETDC IPQFIYKVKN QKKKFKMEFR
G
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 31 | C → S in AAA35222 (Ref. 1) Curated | 1 | |
Sequence conflicti | 48 | N → S in AAA35222 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88172 Genomic DNA Translation: AAA35222.1 Z49260 Genomic DNA Translation: CAA89246.1 AY557972 Genomic DNA Translation: AAS56298.1 BK006946 Genomic DNA Translation: DAA10163.1 |
PIRi | S54475 |
RefSeqi | NP_013990.1, NM_001182770.1 |
Genome annotation databases
EnsemblFungii | YMR263W_mRNA; YMR263W; YMR263W |
GeneIDi | 855305 |
KEGGi | sce:YMR263W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88172 Genomic DNA Translation: AAA35222.1 Z49260 Genomic DNA Translation: CAA89246.1 AY557972 Genomic DNA Translation: AAS56298.1 BK006946 Genomic DNA Translation: DAA10163.1 |
PIRi | S54475 |
RefSeqi | NP_013990.1, NM_001182770.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35441, 608 interactors |
ComplexPortali | CPX-1852, RPD3L histone deacetylase complex |
DIPi | DIP-3846N |
IntActi | P38429, 16 interactors |
MINTi | P38429 |
STRINGi | 4932.YMR263W |
Proteomic databases
MaxQBi | P38429 |
PaxDbi | P38429 |
PRIDEi | P38429 |
Genome annotation databases
EnsemblFungii | YMR263W_mRNA; YMR263W; YMR263W |
GeneIDi | 855305 |
KEGGi | sce:YMR263W |
Organism-specific databases
SGDi | S000004876, SAP30 |
VEuPathDBi | FungiDB:YMR263W |
Phylogenomic databases
eggNOGi | ENOG502RZ9X, Eukaryota |
HOGENOMi | CLU_106811_0_0_1 |
InParanoidi | P38429 |
OMAi | THITNNH |
Enzyme and pathway databases
Reactomei | R-SCE-3214815, HDACs deacetylate histones |
Miscellaneous databases
PROi | PR:P38429 |
RNActi | P38429, protein |
Family and domain databases
Gene3Di | 6.10.160.20, 1 hit |
InterProi | View protein in InterPro IPR024145, His_deAcase_SAP30/SAP30L IPR038291, SAP30_C_sf IPR025718, SAP30_Sin3-bd |
PANTHERi | PTHR13286, PTHR13286, 1 hit |
Pfami | View protein in Pfam PF13867, SAP30_Sin3_bdg, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SAP30_YEAST | |
Accessioni | P38429Primary (citable) accession number: P38429 Secondary accession number(s): D6W089, Q03501 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - SIMILARITY comments
Index of protein domains and families