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UniProtKB - P38424 (ENGB_BACSU)
Protein
Probable GTP-binding protein EngB
Gene
engB
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Necessary for normal cell division and for the maintenance of normal septation.
UniRule annotationBinds GTP and GDP.
Miscellaneous
Estimated to be present at 1000 copies per cell.
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 37 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 59 | MagnesiumUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 30 – 37 | GTPUniRule annotation | 8 | |
Nucleotide bindingi | 57 – 61 | GTPUniRule annotation | 5 | |
Nucleotide bindingi | 75 – 78 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 142 – 145 | GTPUniRule annotation | 4 | |
Nucleotide bindingi | 174 – 176 | GTPUniRule annotation | 3 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- division septum assembly Source: UniProtKB-KW
Keywordsi
Biological process | Cell cycle, Cell division, Septation |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU28190-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable GTP-binding protein EngBUniRule annotation |
Gene namesi | Name:engBUniRule annotation Synonyms:ysxC Ordered Locus Names:BSU28190 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Essential for growth, it cannot be disrupted. In depletion experiments cells become over 3-fold longer, are abnormally curved and nucleoids condense.1 Publication
Chemistry databases
DrugBanki | DB04315, Guanosine-5'-Diphosphate DB04137, Guanosine-5'-Triphosphate |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000157736 | 1 – 195 | Probable GTP-binding protein EngBAdd BLAST | 195 |
Proteomic databases
PaxDbi | P38424 |
Interactioni
Binary interactionsi
P38424
With | #Exp. | IntAct |
---|---|---|
rplA [Q06797] | 3 | EBI-6401087,EBI-6401093 |
rplF [P46898] | 2 | EBI-6401087,EBI-6401129 |
rplL [P02394] | 2 | EBI-6401087,EBI-6401150 |
Protein-protein interaction databases
IntActi | P38424, 7 interactors |
STRINGi | 224308.BSU28190 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P38424 |
SMRi | P38424 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P38424 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 195 | EngB-type GUniRule annotationAdd BLAST | 174 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0218, Bacteria |
InParanoidi | P38424 |
OMAi | LMMDIRH |
PhylomeDBi | P38424 |
Family and domain databases
CDDi | cd01876, YihA_EngB, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00321, GTPase_EngB, 1 hit |
InterProi | View protein in InterPro IPR030393, G_ENGB_dom IPR006073, GTP-bd IPR019987, GTP-bd_ribosome_bio_YsxC IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03598, GTPase_YsxC, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51706, G_ENGB, 1 hit |
i Sequence
Sequence statusi: Complete.
P38424-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVTKSEIVI SAVKPEQYPE GGLPEIALAG RSNVGKSSFI NSLINRKNLA
60 70 80 90 100
RTSSKPGKTQ TLNFYIINDE LHFVDVPGYG FAKVSKSERE AWGRMIETYI
110 120 130 140 150
TTREELKAVV QIVDLRHAPS NDDVQMYEFL KYYGIPVIVI ATKADKIPKG
160 170 180 190
KWDKHAKVVR QTLNIDPEDE LILFSSETKK GKDEAWGAIK KMINR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76424 Genomic DNA Translation: CAA53985.1 Z75208 Genomic DNA Translation: CAA99541.1 AL009126 Genomic DNA Translation: CAB14779.1 |
PIRi | I40422 |
RefSeqi | NP_390697.1, NC_000964.3 WP_003229621.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14779; CAB14779; BSU_28190 |
GeneIDi | 938009 |
KEGGi | bsu:BSU28190 |
PATRICi | fig|224308.179.peg.3062 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76424 Genomic DNA Translation: CAA53985.1 Z75208 Genomic DNA Translation: CAA99541.1 AL009126 Genomic DNA Translation: CAB14779.1 |
PIRi | I40422 |
RefSeqi | NP_390697.1, NC_000964.3 WP_003229621.1, NZ_JNCM01000036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SUL | X-ray | 2.00 | A/B | 1-195 | [»] | |
1SVI | X-ray | 1.95 | A | 1-195 | [»] | |
1SVW | X-ray | 2.80 | A/B | 1-195 | [»] | |
AlphaFoldDBi | P38424 | |||||
SMRi | P38424 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P38424, 7 interactors |
STRINGi | 224308.BSU28190 |
Chemistry databases
DrugBanki | DB04315, Guanosine-5'-Diphosphate DB04137, Guanosine-5'-Triphosphate |
Proteomic databases
PaxDbi | P38424 |
Genome annotation databases
EnsemblBacteriai | CAB14779; CAB14779; BSU_28190 |
GeneIDi | 938009 |
KEGGi | bsu:BSU28190 |
PATRICi | fig|224308.179.peg.3062 |
Phylogenomic databases
eggNOGi | COG0218, Bacteria |
InParanoidi | P38424 |
OMAi | LMMDIRH |
PhylomeDBi | P38424 |
Enzyme and pathway databases
BioCyci | BSUB:BSU28190-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P38424 |
Family and domain databases
CDDi | cd01876, YihA_EngB, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
HAMAPi | MF_00321, GTPase_EngB, 1 hit |
InterProi | View protein in InterPro IPR030393, G_ENGB_dom IPR006073, GTP-bd IPR019987, GTP-bd_ribosome_bio_YsxC IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR03598, GTPase_YsxC, 1 hit TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51706, G_ENGB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ENGB_BACSU | |
Accessioni | P38424Primary (citable) accession number: P38424 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families