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Entry version 187 (17 Jun 2020)
Sequence version 1 (01 Oct 1994)
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Protein

Guanine nucleotide-binding protein G(olf) subunit alpha

Gene

GNAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi56MagnesiumBy similarity1
Metal bindingi191MagnesiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei353GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi49 – 56GTPBy similarity8
Nucleotide bindingi185 – 191GTPBy similarity7
Nucleotide bindingi210 – 214GTPBy similarity5
Nucleotide bindingi279 – 282GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-170660 Adenylate cyclase activating pathway
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-381753 Olfactory Signaling Pathway

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P38405

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(olf) subunit alpha
Alternative name(s):
Adenylate cyclase-stimulating G alpha protein, olfactory type
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000141404.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4388 GNAL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
139312 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P38405

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dystonia 25 (DYT25)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of dystonia, a disorder defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT25 is an autosomal dominant neurologic disorder characterized by adult onset of focal dystonia, usually involving the neck. The dystonia most often progresses to involve other regions, particularly the face and laryngeal muscles, and less commonly the trunk and limbs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069330102 – 104Missing in DYT25. 1 Publication3
Natural variantiVAR_069331137V → M in DYT25; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs398122923Ensembl.1
Natural variantiVAR_069332155E → K in DYT25; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs398122925Ensembl.1

Keywords - Diseasei

Disease mutation, Dystonia

Organism-specific databases

DisGeNET

More...
DisGeNETi
2774

MalaCards human disease database

More...
MalaCardsi
GNAL
MIMi615073 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000141404

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
329466 Autosomal dominant focal dystonia, DYT25 type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28770

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P38405 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GNAL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
585178

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002037322 – 381Guanine nucleotide-binding protein G(olf) subunit alphaAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-palmitoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei178PhosphothreonineBy similarity1
Modified residuei188ADP-ribosylarginine; by cholera toxinBy similarity1

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P38405

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P38405

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P38405

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38405

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38405

PeptideAtlas

More...
PeptideAtlasi
P38405

PRoteomics IDEntifications database

More...
PRIDEi
P38405

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55293 [P38405-1]
55294 [P38405-2]
7052

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38405

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P38405

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P38405

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141404 Expressed in caudate nucleus and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P38405 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P38405 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141404 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Interacts with GAS2L2 (PubMed:23994616).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109036, 9 interactors

Protein interaction database and analysis system

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IntActi
P38405, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334051

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38405 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38405

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 381G-alphaPROSITE-ProRule annotationAdd BLAST341

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 57G1 motifPROSITE-ProRule annotationAdd BLAST14
Regioni183 – 191G2 motifPROSITE-ProRule annotation9
Regioni206 – 215G3 motifPROSITE-ProRule annotation10
Regioni275 – 282G4 motifPROSITE-ProRule annotation8
Regioni351 – 356G5 motifPROSITE-ProRule annotation6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-alpha family. G(s) subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0099 Eukaryota
ENOG410XPC4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155271

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014184_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38405

KEGG Orthology (KO)

More...
KOi
K04633

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWKNRWL

Database of Orthologous Groups

More...
OrthoDBi
754573at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P38405

TreeFam database of animal gene trees

More...
TreeFami
TF300673

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00066 G-alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10218 PTHR10218, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00503 G-alpha, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00318 GPROTEINA
PR00443 GPROTEINAS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00275 G_alpha, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51882 G_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P38405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCLGGNSKT TEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA
60 70 80 90 100
GESGKSTIVK QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI
110 120 130 140 150
IPPVPLANPE NQFRSDYIKS IAPITDFEYS QEFFDHVKKL WDDEGVKACF
160 170 180 190 200
ERSNEYQLID CAQYFLERID SVSLVDYTPT DQDLLRCRVL TSGIFETRFQ
210 220 230 240 250
VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY NMVIREDNNT
260 270 280 290 300
NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP
310 320 330 340 350
EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF
360 370 380
TCAVDTENIR RVFNDCRDII QRMHLKQYEL L
Length:381
Mass (Da):44,308
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A73D2982FF9C9A3
GO
Isoform 2 (identifier: P38405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MGCLGGNSKT...LQKERLAYKA → MGLCYSLRPL...LRDQKRDLQQ

Show »
Length:458
Mass (Da):52,455
Checksum:i89231879924C06A1
GO
Isoform 3 (identifier: P38405-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.

Show »
Length:174
Mass (Da):20,522
Checksum:i62867F7352FAA433
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPE2K7EPE2_HUMAN
Guanine nucleotide-binding protein ...
GNAL
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ80K7EQ80_HUMAN
Guanine nucleotide-binding protein ...
GNAL
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMY6K7EMY6_HUMAN
Guanine nucleotide-binding protein ...
GNAL
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06932916V → F1 PublicationCorresponds to variant dbSNP:rs1039372506Ensembl.1
Natural variantiVAR_069330102 – 104Missing in DYT25. 1 Publication3
Natural variantiVAR_069331137V → M in DYT25; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs398122923Ensembl.1
Natural variantiVAR_069332155E → K in DYT25; loss of function mutation. 1 PublicationCorresponds to variant dbSNP:rs398122925Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451301 – 207Missing in isoform 3. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_0430501 – 41MGCLG…LAYKA → MGLCYSLRPLLFGGPGDDPC AASEPPVEDAQPAPAPALAP VRAAARDTARTLLPRGGEGS PACARPKADKPKEKRQRTEQ LSAEEREAAKEREAVKEARK VSRGIDRMLRDQKRDLQQ in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L10665 mRNA Translation: AAC37535.1
U55184 U55183 Genomic DNA Translation: AAD00085.1
AF493893 mRNA Translation: AAM12607.1
AK316141 mRNA Translation: BAH14512.1
AP001120 Genomic DNA No translation available.
AP001269 Genomic DNA No translation available.
AP005137 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01573.1
BC050021 mRNA Translation: AAH50021.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11851.1 [P38405-2]
CCDS11852.1 [P38405-1]
CCDS58614.1 [P38405-3]

Protein sequence database of the Protein Information Resource

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PIRi
I53271

NCBI Reference Sequences

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RefSeqi
NP_001135811.1, NM_001142339.2 [P38405-1]
NP_001248372.1, NM_001261443.1 [P38405-1]
NP_001248373.1, NM_001261444.1 [P38405-3]
NP_892023.1, NM_182978.3 [P38405-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000269162; ENSP00000269162; ENSG00000141404 [P38405-1]
ENST00000334049; ENSP00000334051; ENSG00000141404 [P38405-2]
ENST00000423027; ENSP00000408489; ENSG00000141404 [P38405-1]
ENST00000535121; ENSP00000439023; ENSG00000141404 [P38405-1]
ENST00000602628; ENSP00000473600; ENSG00000141404 [P38405-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2774

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2774

UCSC genome browser

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UCSCi
uc002kqc.4 human [P38405-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10665 mRNA Translation: AAC37535.1
U55184 U55183 Genomic DNA Translation: AAD00085.1
AF493893 mRNA Translation: AAM12607.1
AK316141 mRNA Translation: BAH14512.1
AP001120 Genomic DNA No translation available.
AP001269 Genomic DNA No translation available.
AP005137 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01573.1
BC050021 mRNA Translation: AAH50021.1
CCDSiCCDS11851.1 [P38405-2]
CCDS11852.1 [P38405-1]
CCDS58614.1 [P38405-3]
PIRiI53271
RefSeqiNP_001135811.1, NM_001142339.2 [P38405-1]
NP_001248372.1, NM_001261443.1 [P38405-1]
NP_001248373.1, NM_001261444.1 [P38405-3]
NP_892023.1, NM_182978.3 [P38405-2]

3D structure databases

SMRiP38405
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109036, 9 interactors
IntActiP38405, 14 interactors
STRINGi9606.ENSP00000334051

PTM databases

iPTMnetiP38405
PhosphoSitePlusiP38405
SwissPalmiP38405

Polymorphism and mutation databases

BioMutaiGNAL
DMDMi585178

Proteomic databases

EPDiP38405
jPOSTiP38405
MassIVEiP38405
MaxQBiP38405
PaxDbiP38405
PeptideAtlasiP38405
PRIDEiP38405
ProteomicsDBi55293 [P38405-1]
55294 [P38405-2]
7052

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4227 160 antibodies

The DNASU plasmid repository

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DNASUi
2774

Genome annotation databases

EnsembliENST00000269162; ENSP00000269162; ENSG00000141404 [P38405-1]
ENST00000334049; ENSP00000334051; ENSG00000141404 [P38405-2]
ENST00000423027; ENSP00000408489; ENSG00000141404 [P38405-1]
ENST00000535121; ENSP00000439023; ENSG00000141404 [P38405-1]
ENST00000602628; ENSP00000473600; ENSG00000141404 [P38405-3]
GeneIDi2774
KEGGihsa:2774
UCSCiuc002kqc.4 human [P38405-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2774
DisGeNETi2774
EuPathDBiHostDB:ENSG00000141404.15

GeneCards: human genes, protein and diseases

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GeneCardsi
GNAL
HGNCiHGNC:4388 GNAL
HPAiENSG00000141404 Tissue enhanced (brain)
MalaCardsiGNAL
MIMi139312 gene
615073 phenotype
neXtProtiNX_P38405
OpenTargetsiENSG00000141404
Orphaneti329466 Autosomal dominant focal dystonia, DYT25 type
PharmGKBiPA28770

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00940000155271
HOGENOMiCLU_014184_3_0_1
InParanoidiP38405
KOiK04633
OMAiIWKNRWL
OrthoDBi754573at2759
PhylomeDBiP38405
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-HSA-170660 Adenylate cyclase activating pathway
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-381753 Olfactory Signaling Pathway
SIGNORiP38405

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
2774 0 hits in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GNAL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GNAL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2774
PharosiP38405 Tbio

Protein Ontology

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PROi
PR:P38405
RNActiP38405 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141404 Expressed in caudate nucleus and 220 other tissues
ExpressionAtlasiP38405 baseline and differential
GenevisibleiP38405 HS

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51882 G_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNAL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38405
Secondary accession number(s): B7ZA26, Q86XU3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 17, 2020
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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