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Entry version 167 (29 Sep 2021)
Sequence version 1 (01 Oct 1994)
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Protein

Essential nuclear protein 1

Gene

ENP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunit shifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein.

2 Publications

Miscellaneous

Present with 21600 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Essential nuclear protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENP1
Synonyms:MEG1
Ordered Locus Names:YBR247C
ORF Names:YBR1635
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000451, ENP1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YBR247C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861181 – 483Essential nuclear protein 1Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei172Phosphoserine; by ATM or ATRCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P38333

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38333

PRoteomics IDEntifications database

More...
PRIDEi
P38333

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38333

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32942, 356 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1604, Small ribosomal subunit processome, variant 1
CPX-1607, Small ribosomal subunit processome, variant 2
CPX-1608, Small ribosomal subunit processome, variant 3

Database of interacting proteins

More...
DIPi
DIP-6612N

Protein interaction database and analysis system

More...
IntActi
P38333, 107 interactors

Molecular INTeraction database

More...
MINTi
P38333

STRING: functional protein association networks

More...
STRINGi
4932.YBR247C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38333, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1483
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38333

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni33 – 55DisorderedSequence analysisAdd BLAST23
Regioni67 – 123DisorderedSequence analysisAdd BLAST57
Regioni171 – 200DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi67 – 87Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi95 – 123Acidic residuesSequence analysisAdd BLAST29
Compositional biasi183 – 197Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bystin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3871, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007241

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029727_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38333

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPHWEDI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007955, Bystin

The PANTHER Classification System

More...
PANTHERi
PTHR12821, PTHR12821, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05291, Bystin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38333-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARASSTKAR KQRHDPLLKD LDAAQGTLKK INKKKLAQND AANHDAANEE
60 70 80 90 100
DGYIDSKASR KILQLAKEQQ DEIEGEELAE SERNKQFEAR FTTMSYDDED
110 120 130 140 150
EDEDEDEEAF GEDISDFEPE GDYKEEEEIV EIDEEDAAMF EQYFKKSDDF
160 170 180 190 200
NSLSGSYNLA DKIMASIREK ESQVEDMQDD EPLANEQNTS RGNISSGLKS
210 220 230 240 250
GEGVALPEKV IKAYTTVGSI LKTWTHGKLP KLFKVIPSLR NWQDVIYVTN
260 270 280 290 300
PEEWSPHVVY EATKLFVSNL TAKESQKFIN LILLERFRDN IETSEDHSLN
310 320 330 340 350
YHIYRAVKKS LYKPSAFFKG FLFPLVETGC NVREATIAGS VLAKVSVPAL
360 370 380 390 400
HSSAALSYLL RLPFSPPTTV FIKILLDKKY ALPYQTVDDC VYYFMRFRIL
410 420 430 440 450
DDGSNGEDAT RVLPVIWHKA FLTFAQRYKN DITQDQRDFL LETVRQRGHK
460 470 480
DIGPEIRREL LAGASREFVD PQEANDDLMI DVN
Length:483
Mass (Da):55,137
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i399A415131294637
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U50779 Genomic DNA Translation: AAC49647.1
Z36116 Genomic DNA Translation: CAA85210.1
BK006936 Genomic DNA Translation: DAA07363.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46124

NCBI Reference Sequences

More...
RefSeqi
NP_009806.3, NM_001178595.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR247C_mRNA; YBR247C; YBR247C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR247C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50779 Genomic DNA Translation: AAC49647.1
Z36116 Genomic DNA Translation: CAA85210.1
BK006936 Genomic DNA Translation: DAA07363.1
PIRiS46124
RefSeqiNP_009806.3, NM_001178595.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WLCelectron microscopy3.80SZ1-483[»]
5WWOX-ray2.40A/B121-483[»]
5WYJelectron microscopy8.70E31-483[»]
6EMLelectron microscopy3.60e1-483[»]
6FAIelectron microscopy3.40i1-483[»]
6KE6electron microscopy3.40RS1-483[»]
6LQPelectron microscopy3.20RS1-483[»]
6LQQelectron microscopy4.10RS1-483[»]
6LQRelectron microscopy8.60RS1-483[»]
6LQSelectron microscopy3.80RS1-480[»]
6LQUelectron microscopy3.70RS1-483[»]
6LQVelectron microscopy4.80RS1-483[»]
6RBDelectron microscopy3.47i1-483[»]
6Y7Celectron microscopy3.80i1-483[»]
6ZQAelectron microscopy4.40JH1-483[»]
6ZQBelectron microscopy3.90JH1-483[»]
6ZQCelectron microscopy3.80JH1-483[»]
6ZQDelectron microscopy3.80JH1-483[»]
6ZQEelectron microscopy7.10JH1-483[»]
6ZQFelectron microscopy4.90JH1-483[»]
6ZQGelectron microscopy3.50JH1-483[»]
7AJTelectron microscopy4.60JH1-483[»]
7AJUelectron microscopy3.80JH1-483[»]
SMRiP38333
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32942, 356 interactors
ComplexPortaliCPX-1604, Small ribosomal subunit processome, variant 1
CPX-1607, Small ribosomal subunit processome, variant 2
CPX-1608, Small ribosomal subunit processome, variant 3
DIPiDIP-6612N
IntActiP38333, 107 interactors
MINTiP38333
STRINGi4932.YBR247C

PTM databases

iPTMnetiP38333

Proteomic databases

MaxQBiP38333
PaxDbiP38333
PRIDEiP38333

Genome annotation databases

EnsemblFungiiYBR247C_mRNA; YBR247C; YBR247C
GeneIDi852549
KEGGisce:YBR247C

Organism-specific databases

SGDiS000000451, ENP1
VEuPathDBiFungiDB:YBR247C

Phylogenomic databases

eggNOGiKOG3871, Eukaryota
GeneTreeiENSGT00390000007241
HOGENOMiCLU_029727_0_1_1
InParanoidiP38333
OMAiIPHWEDI

Enzyme and pathway databases

ReactomeiR-SCE-6791226, Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38333
RNActiP38333, protein

Family and domain databases

InterProiView protein in InterPro
IPR007955, Bystin
PANTHERiPTHR12821, PTHR12821, 1 hit
PfamiView protein in Pfam
PF05291, Bystin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENP1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38333
Secondary accession number(s): D6VQP3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 29, 2021
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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