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Entry version 129 (02 Jun 2021)
Sequence version 1 (01 Oct 1994)
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Protein

Uncharacterized membrane protein YBR220C

Gene

YBR220C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-425397, Transport of vitamins, nucleosides, and related molecules

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.25.4, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized membrane protein YBR220C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YBR220C
ORF Names:YBR1510
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000424, YBR220C

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YBR220C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 54ExtracellularSequence analysisAdd BLAST16
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 88CytoplasmicSequence analysisAdd BLAST13
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 139ExtracellularSequence analysisAdd BLAST30
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161 – 172CytoplasmicSequence analysisAdd BLAST12
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 214ExtracellularSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 329CytoplasmicSequence analysisAdd BLAST94
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 374ExtracellularSequence analysisAdd BLAST24
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 421CytoplasmicSequence analysisAdd BLAST26
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 521ExtracellularSequence analysisAdd BLAST79
Transmembranei522 – 542HelicalSequence analysisAdd BLAST21
Topological domaini543 – 560CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002025141 – 560Uncharacterized membrane protein YBR220CAdd BLAST560

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38318

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38318

PRoteomics IDEntifications database

More...
PRIDEi
P38318

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38318

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32917, 67 interactors

Database of interacting proteins

More...
DIPi
DIP-5702N

Protein interaction database and analysis system

More...
IntActi
P38318, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YBR220C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38318, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3574, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154019

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020502_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38318

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWFWGIT

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024371, AcetylCoA_trans_1-like
IPR004752, AmpG_permease/AT-1
IPR036259, MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12778, PTHR12778, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13000, Acatn, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38318-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPKRKSGSL AKHDLPQFYL LIMLYLAQGI PVGLAFGTVP FLLKSLAKET
60 70 80 90 100
SFTSLGIFSM ATYPYSLKII WSPIVDSLYN KRIGRRRSWI IPVQFVSGFV
110 120 130 140 150
LWALGWCISQ GIIFDGVDDA FHNRGNGTLH SVSIKNLTWW FGLLVFLCAT
160 170 180 190 200
QDIAVDGWAL TILSKESLSY ASTAQTIGLN IGYFMSFTIF LSLNSSDFAN
210 220 230 240 250
KYFRNIPLDH GFISLGGYMK FSGMLYIVIT IYIIFCTKEK PYVEYLPKVE
260 270 280 290 300
PINTSDGGSK PISIEYDDGD VVSTQNTSSI KYIYRCFIKV LKLKSVRSLA
310 320 330 340 350
FIHMISKFAF QCNEAATNLK LLEQGFKRED LAVTVLIDLP FEIIFGYYVV
360 370 380 390 400
KWSSDKDPMI RDNRRLRNST GTNKVIKFLV GDAGVLTPWL WGFLGRLAAA
410 420 430 440 450
VLGSYVVKQF PKDGEISTGY FCLVIFQHLL GSFMNTVQFI GISAFHTRVA
460 470 480 490 500
DPVLGGTYMT LLNTLSNFGG TWPRLIIMSM INYFTVYQCT IPGTNKVYVT
510 520 530 540 550
HGGSMQACTE LLNGTVTILR DGYYITNLIC IVVGLFLYFG YLKRKILHLQ
560
SLPISSWRCT
Length:560
Mass (Da):63,010
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD10A20FA041B5DF3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z36088 Genomic DNA Translation: CAA85183.1
BK006936 Genomic DNA Translation: DAA07336.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46096

NCBI Reference Sequences

More...
RefSeqi
NP_009779.3, NM_001178568.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR220C_mRNA; YBR220C; YBR220C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852521

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR220C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36088 Genomic DNA Translation: CAA85183.1
BK006936 Genomic DNA Translation: DAA07336.1
PIRiS46096
RefSeqiNP_009779.3, NM_001178568.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi32917, 67 interactors
DIPiDIP-5702N
IntActiP38318, 1 interactor
STRINGi4932.YBR220C

Protein family/group databases

TCDBi2.A.1.25.4, the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP38318

Proteomic databases

MaxQBiP38318
PaxDbiP38318
PRIDEiP38318

Genome annotation databases

EnsemblFungiiYBR220C_mRNA; YBR220C; YBR220C
GeneIDi852521
KEGGisce:YBR220C

Organism-specific databases

SGDiS000000424, YBR220C
VEuPathDBiFungiDB:YBR220C

Phylogenomic databases

eggNOGiKOG3574, Eukaryota
GeneTreeiENSGT00940000154019
HOGENOMiCLU_020502_1_1_1
InParanoidiP38318
OMAiLWFWGIT

Enzyme and pathway databases

ReactomeiR-SCE-425397, Transport of vitamins, nucleosides, and related molecules

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38318
RNActiP38318, protein

Family and domain databases

InterProiView protein in InterPro
IPR024371, AcetylCoA_trans_1-like
IPR004752, AmpG_permease/AT-1
IPR036259, MFS_trans_sf
PANTHERiPTHR12778, PTHR12778, 1 hit
PfamiView protein in Pfam
PF13000, Acatn, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYB70_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38318
Secondary accession number(s): D6VQL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 2, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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