Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 123 (13 Feb 2019)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

F-box protein COS111

Gene

COS111

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • signal transduction Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29144-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F-box protein COS111
Alternative name(s):
Ciclopirox olamine sensitivity protein 111
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COS111
Ordered Locus Names:YBR203W
ORF Names:YBR1443
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YBR203W

Saccharomyces Genome Database

More...
SGDi
S000000407 COS111

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002025091 – 924F-box protein COS111Add BLAST924

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38308

PRoteomics IDEntifications database

More...
PRIDEi
P38308

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32900, 105 interactors

Database of interacting proteins

More...
DIPi
DIP-4943N

Protein interaction database and analysis system

More...
IntActi
P38308, 9 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YBR203W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P38308

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini185 – 236F-boxAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 162Ser-richAdd BLAST161
Compositional biasi354 – 475Ser-richAdd BLAST122

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112003

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38308

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLGYILH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047 F-box-like_dom_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81383 SSF81383, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38308-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSASRLQNV NIVSNNYSRY GTSVYDKLYH SNGSGSNNAG KNSTTVGKLS
60 70 80 90 100
SISQKSRSKQ RHGSNCSRSM SQSPLSTFKS PLSNQNQSSA PDDLASIGQR
110 120 130 140 150
RSDDVTSLDN ETIITMNSRK SRIKKKYKSL ISTSSKKFMN KLYDHGASSD
160 170 180 190 200
SFSIFSLKTS HSGKHENSRF EKLRKRKYHA WGKFADINDL PVEIIAKILS
210 220 230 240 250
EFELGRDQKT LVRCLYVSKK FYKATKIVLY RLPYFTSTYR VAQFVTSLRL
260 270 280 290 300
HPDNGAYVKV LDLSHLKPGI IGQDSKDSQG LDDDGHSRRH RRRRRRSTNT
310 320 330 340 350
SLNLPPATPT STISNEDDAN SGLIKDDASN GSEVEDLALA GWRDWRYRNE
360 370 380 390 400
PLYSSPLLNS FKLKKVVSRS SSITSTSSGN STGVHSTRRQ RSNSSVASIT
410 420 430 440 450
TSIMSSIYNT SHVSLSSTTS NTSNGNISSG SNLSRVSTAG SLKKASAKST
460 470 480 490 500
RSSPQKAKPI SDITSSSWFR MRLSSRNRKA RTANTINLKN SKDKSDDDFK
510 520 530 540 550
VLKHDSGHPS NYRSSTLKFS IEQPFSTHHP YANKFLLKYA PYKDLPLGYI
560 570 580 590 600
LHMLNLCPNL VELNLSNLVI CTDFKLINQR SERRRMTSSL LPAVQESSVS
610 620 630 640 650
AGPEKDLEIV YMTDSGKGYE YYEGLSKKHS RSSSLGTNPS SWIGGQANWT
660 670 680 690 700
DYPPPIDAQT KTREEHRRNN TLNNKNVVLK KLNPFEIFEM ICNRNEEKGG
710 720 730 740 750
YCSLTKVKMN DIVWCRQYMV KYFVMRTFRQ HLDYKSMENN SYERHLFSFR
760 770 780 790 800
DSGLDRNFSW ACNAKLHEFV ALMVMDHLSN LDDLGLEELF NIKSEKLYIK
810 820 830 840 850
NYCCRDPDIL EISNLFDIRY GAGSEADATS DSNLEAESLQ FRLTILKTEK
860 870 880 890 900
PTSFWLTKVS KDYVSLVVKL CVDDDIDMDK MKVGKPTLRI DSITHNLISR
910 920
LKELRRVDLR RNVGENNYYA ESII
Length:924
Mass (Da):104,615
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B3C940BB8FC10DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti727 – 731TFRQH → SWRND in CAA79691 (PubMed:8368014).Curated5
Sequence conflicti727 – 731TFRQH → SWRND in CAA85167 (PubMed:7813418).Curated5
Sequence conflicti917N → S in CAA79691 (PubMed:8368014).Curated1
Sequence conflicti917N → S in CAA85167 (PubMed:7813418).Curated1
Sequence conflicti921E → G in CAA79691 (PubMed:8368014).Curated1
Sequence conflicti921E → G in CAA85167 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z21487 Genomic DNA Translation: CAA79691.1
Z36072 Genomic DNA Translation: CAA85167.1
BK006936 Genomic DNA Translation: DAA07321.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S34926

NCBI Reference Sequences

More...
RefSeqi
NP_009762.2, NM_001178551.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR203W_mRNA; YBR203W_mRNA; YBR203W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852502

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR203W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21487 Genomic DNA Translation: CAA79691.1
Z36072 Genomic DNA Translation: CAA85167.1
BK006936 Genomic DNA Translation: DAA07321.2
PIRiS34926
RefSeqiNP_009762.2, NM_001178551.2

3D structure databases

ProteinModelPortaliP38308
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32900, 105 interactors
DIPiDIP-4943N
IntActiP38308, 9 interactors
STRINGi4932.YBR203W

Proteomic databases

PaxDbiP38308
PRIDEiP38308

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR203W_mRNA; YBR203W_mRNA; YBR203W
GeneIDi852502
KEGGisce:YBR203W

Organism-specific databases

EuPathDBiFungiDB:YBR203W
SGDiS000000407 COS111

Phylogenomic databases

HOGENOMiHOG000112003
InParanoidiP38308
OMAiPLGYILH

Enzyme and pathway databases

BioCyciYEAST:G3O-29144-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38308

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
SUPFAMiSSF81383 SSF81383, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCS111_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38308
Secondary accession number(s): D6VQK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: February 13, 2019
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again