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Protein

Ribonucleases P/MRP protein subunit POP7

Gene

POP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.2 Publications

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processrRNA processing, tRNA processing

Enzyme and pathway databases

BioCyciYEAST:YBR167C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleases P/MRP protein subunit POP7 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein POP7
RNases P/MRP 15.8 kDa subunit
Gene namesi
Name:POP7
Synonyms:RPP2
Ordered Locus Names:YBR167C
ORF Names:YBR1219
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

SGDiS000000371 POP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585191 – 140Ribonucleases P/MRP protein subunit POP7Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38291
PaxDbiP38291
PRIDEiP38291
TopDownProteomicsiP38291

PTM databases

iPTMnetiP38291

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi32867, 473 interactors
ComplexPortaliCPX-1873 Nucleolar ribonuclease P complex
CPX-3284 Nucleolar ribonuclease MRP complex
DIPiDIP-5462N
IntActiP38291, 10 interactors
MINTiP38291
STRINGi4932.YBR167C

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP38291
SMRiP38291
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38291

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

HOGENOMiHOG000248080
InParanoidiP38291
KOiK14526
OMAiGQADIDM
OrthoDBiEOG092C5VPB

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR014612 Pop7/Rpp20
IPR020241 RNase_P/MRP_POP7
PANTHERiPTHR28256 PTHR28256, 2 hits
PfamiView protein in Pfam
PF12328 Rpp20, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD085500 Ribonuclease_P/MRP_su_POP7, 1 hit

Sequencei

Sequence statusi: Complete.

P38291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKKNTHNK STKRVTKHPS LKTLTHKQIH TTIFVKSTTP YVSALKRINK
60 70 80 90 100
FLDSVHKQGS SYVAVLGMGK AVEKTLALGC HFQDQKNKKI EVYTKTIEVL
110 120 130 140
DEVITEGQAD IDMESDVEDD DKETQLKKRA VSGVELRIYV
Length:140
Mass (Da):15,814
Last modified:October 1, 1994 - v1
Checksum:iB507BFDC7ED9C95C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92V → I in AAT92849 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055991 Genomic DNA Translation: AAC24226.1
Z36036 Genomic DNA Translation: CAA85128.1
AY692830 Genomic DNA Translation: AAT92849.1
BK006936 Genomic DNA Translation: DAA07283.1
PIRiS46038
RefSeqiNP_009726.3, NM_001178515.3

Genome annotation databases

EnsemblFungiiYBR167C; YBR167C; YBR167C
GeneIDi852465
KEGGisce:YBR167C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055991 Genomic DNA Translation: AAC24226.1
Z36036 Genomic DNA Translation: CAA85128.1
AY692830 Genomic DNA Translation: AAT92849.1
BK006936 Genomic DNA Translation: DAA07283.1
PIRiS46038
RefSeqiNP_009726.3, NM_001178515.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IABX-ray2.70B1-140[»]
ProteinModelPortaliP38291
SMRiP38291
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32867, 473 interactors
ComplexPortaliCPX-1873 Nucleolar ribonuclease P complex
CPX-3284 Nucleolar ribonuclease MRP complex
DIPiDIP-5462N
IntActiP38291, 10 interactors
MINTiP38291
STRINGi4932.YBR167C

PTM databases

iPTMnetiP38291

Proteomic databases

MaxQBiP38291
PaxDbiP38291
PRIDEiP38291
TopDownProteomicsiP38291

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR167C; YBR167C; YBR167C
GeneIDi852465
KEGGisce:YBR167C

Organism-specific databases

SGDiS000000371 POP7

Phylogenomic databases

HOGENOMiHOG000248080
InParanoidiP38291
KOiK14526
OMAiGQADIDM
OrthoDBiEOG092C5VPB

Enzyme and pathway databases

BioCyciYEAST:YBR167C-MONOMER

Miscellaneous databases

EvolutionaryTraceiP38291
PROiPR:P38291

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR014612 Pop7/Rpp20
IPR020241 RNase_P/MRP_POP7
PANTHERiPTHR28256 PTHR28256, 2 hits
PfamiView protein in Pfam
PF12328 Rpp20, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD085500 Ribonuclease_P/MRP_su_POP7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOP7_YEAST
AccessioniPrimary (citable) accession number: P38291
Secondary accession number(s): D6VQG3, E9P8X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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Main funding by: National Institutes of Health

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