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Protein

Vacuolar fusion protein CCZ1

Gene

CCZ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.8 Publications

Miscellaneous

Present with 2870 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-29086-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar fusion protein CCZ1
Alternative name(s):
Autophagy-related protein 11
Calcium-caffeine-zinc sensitivity protein 1
Cytoplasm to vacuole targeting protein 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCZ1
Synonyms:AUT11, CVT16
Ordered Locus Names:YBR131W
ORF Names:YBR1006
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000335 CCZ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002024911 – 704Vacuolar fusion protein CCZ1Add BLAST704

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P38273

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P38273

PRoteomics IDEntifications database

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PRIDEi
P38273

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with MON1. Interacts with YPT7.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MON1P531294EBI-21608,EBI-23945

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
32832, 435 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1674 MON1-CCZ1 complex

Database of interacting proteins

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DIPi
DIP-7853N

Protein interaction database and analysis system

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IntActi
P38273, 4 interactors

Molecular INTeraction database

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MINTi
P38273

STRING: functional protein association networks

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STRINGi
4932.YBR131W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P38273

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38273

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCZ1 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000111457

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P38273

KEGG Orthology (KO)

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KOi
K21156

Identification of Orthologs from Complete Genome Data

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OMAi
YGEISSH

Database of Orthologous Groups

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OrthoDBi
EOG092C3Y5M

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013176 Ccz1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08217 DUF1712, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF011668 DUF1712_fun, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLHYITVFD PSRSTNENDT FKQLLLFHYF GTTDSIPSLN EKLSIIGVIQ
60 70 80 90 100
GIWSLTSSCV NKDGEDLEKI IELNNDIIFC IKVESRFFIS LAISNISDDQ
110 120 130 140 150
SAIPLQYLSA YLWLSYRFFK LLNGSFSGFN KDFRKLTDLL NEFVIPFWND
160 170 180 190 200
IYLNLETVTN RSFTVMWPGF YKRANFQHSS YNPGEKNNVE ESWDAIILQN
210 220 230 240 250
ILLDKKSYLG LKDILVYHLP KRTKAANRES MGTKTYGLVR NFTSDLNTLP
260 270 280 290 300
DISNWLYHLH CTYGEISSHI LTGNVHFKEE LQVEEEQERS RDTNGRDEEE
310 320 330 340 350
SQEQQRREHQ ETTQNNTSEL SLSERVIHNV TLPISFAYDA IHEVSTTTGV
360 370 380 390 400
SGSLSMIMDY VPKPHWPFIS SSNKSADKNN YSNSNDNANS NAPLMAQSEA
410 420 430 440 450
VGGTIGNSRF GFLISPLNSD LLPSSYQALK LNLNFENSKD KEDFYNCLFW
460 470 480 490 500
YFDDFLIVIV CDPDFNKICE RDYLKDLSFQ LCQSMECLNN EILNSQNCDN
510 520 530 540 550
VESFAYVIRD NVTKEIDSSV PFGSPKFTSD ESISTLQLAI NGIDQFINDN
560 570 580 590 600
SNSLSLANWN PITIMGGSNA ISKKNTTEGF GNGVNDKTQK FKRKYLNFLN
610 620 630 640 650
LMSAEKLWDL QVDVLQFLTS LQNSKRDPDY FQEERLLKLN NGVLCYIKEN
660 670 680 690 700
NSNLIIIIKN WFQNNGTSKA AKQRNRFSSD SSKGSSLFQS LGRDVTDWWE

SREI
Length:704
Mass (Da):80,732
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE037AD8DBFCC3BDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75891 Genomic DNA Translation: CAA53490.1
Z36000 Genomic DNA Translation: CAA85088.1
AY693208 Genomic DNA Translation: AAT93227.1
BK006936 Genomic DNA Translation: DAA07248.1

Protein sequence database of the Protein Information Resource

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PIRi
S46000

NCBI Reference Sequences

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RefSeqi
NP_009689.3, NM_001178479.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR131W_mRNA; YBR131W_mRNA; YBR131W

Database of genes from NCBI RefSeq genomes

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GeneIDi
852428

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR131W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75891 Genomic DNA Translation: CAA53490.1
Z36000 Genomic DNA Translation: CAA85088.1
AY693208 Genomic DNA Translation: AAT93227.1
BK006936 Genomic DNA Translation: DAA07248.1
PIRiS46000
RefSeqiNP_009689.3, NM_001178479.3

3D structure databases

ProteinModelPortaliP38273
SMRiP38273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32832, 435 interactors
ComplexPortaliCPX-1674 MON1-CCZ1 complex
DIPiDIP-7853N
IntActiP38273, 4 interactors
MINTiP38273
STRINGi4932.YBR131W

Proteomic databases

MaxQBiP38273
PaxDbiP38273
PRIDEiP38273

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR131W_mRNA; YBR131W_mRNA; YBR131W
GeneIDi852428
KEGGisce:YBR131W

Organism-specific databases

SGDiS000000335 CCZ1

Phylogenomic databases

HOGENOMiHOG000111457
InParanoidiP38273
KOiK21156
OMAiYGEISSH
OrthoDBiEOG092C3Y5M

Enzyme and pathway databases

BioCyciYEAST:G3O-29086-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38273

Family and domain databases

InterProiView protein in InterPro
IPR013176 Ccz1
PfamiView protein in Pfam
PF08217 DUF1712, 1 hit
PIRSFiPIRSF011668 DUF1712_fun, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCZ1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38273
Secondary accession number(s): D6VQC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 5, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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