UniProtKB - P38261 (EXO84_YEAST)
Protein
Exocyst complex component EXO84
Gene
EXO84
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis and to the budding site. Also involved in assembly of the spliceosome.3 Publications
GO - Biological processi
- exocyst assembly Source: SGD
- exocyst localization Source: SGD
- exocytosis Source: SGD
- Golgi to plasma membrane transport Source: SGD
- protein localization Source: GO_Central
- protein transport Source: UniProtKB-KW
- spliceosomal complex assembly Source: SGD
- vesicle tethering involved in exocytosis Source: SGD
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29064-MONOMER |
Reactomei | R-SCE-264876, Insulin processing |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component EXO84Alternative name(s): Exocyst complex protein of 84 kDa U1 SNP1-associating protein 3 |
Gene namesi | Name:EXO84 Synonyms:USA3 Ordered Locus Names:YBR102C ORF Names:YBR0831 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000306, EXO84 |
VEuPathDBi | FungiDB:YBR102C |
Subcellular locationi
Other locations
Note: Cell periphery, bud and bud neck. The polarization of EXO84 requires actin cables.
Other locations
- cellular bud neck Source: SGD
- cellular bud tip Source: SGD
- exocyst Source: SGD
- incipient cellular bud site Source: SGD
- mating projection tip Source: SGD
- prospore membrane Source: SGD
- transport vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesiclePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118987 | 1 – 753 | Exocyst complex component EXO84Add BLAST | 753 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 58 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources | 1 | |
Cross-linki | 219 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 482 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P38261 |
PaxDbi | P38261 |
PRIDEi | P38261 |
PTM databases
iPTMneti | P38261 |
Interactioni
Subunit structurei
Component of the exocyst complex composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.
Interacts also with SNP1.
2 PublicationsBinary interactionsi
Hide detailsP38261
Protein-protein interaction databases
BioGRIDi | 32806, 318 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-2732N |
IntActi | P38261, 19 interactors |
MINTi | P38261 |
STRINGi | 4932.YBR102C |
Miscellaneous databases
RNActi | P38261, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P38261 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P38261 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 227 – 279 | Sequence analysisAdd BLAST | 53 | |
Coiled coili | 531 – 585 | Sequence analysisAdd BLAST | 55 |
Sequence similaritiesi
Belongs to the EXO84 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2215, Eukaryota |
GeneTreei | ENSGT00390000015936 |
HOGENOMi | CLU_014732_0_0_1 |
InParanoidi | P38261 |
OMAi | FKILMFP |
Family and domain databases
Gene3Di | 1.20.58.1210, 1 hit 1.20.58.1220, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR016159, Cullin_repeat-like_dom_sf IPR033961, Exo84 IPR032403, Exo84_C IPR042561, Exo84_C_1 IPR042560, Exo84_C_2 IPR011993, PH-like_dom_sf |
PANTHERi | PTHR21426, PTHR21426, 1 hit |
Pfami | View protein in Pfam PF16528, Exo84_C, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
i Sequence
Sequence statusi: Complete.
P38261-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVEFSLKKAR NNWKHVKKSA SSPAKQKTPP SPAKPKQKTK KNPYSDLKDP
60 70 80 90 100
ATSYTLPTIN ARERSRVATS MQRRLSIHNT NYAPPTLDYS MPLPDMPNMI
110 120 130 140 150
VPNDNVDSSH NNSSFTTENE SVSSKGPSNS LNLSTADLSL NDSSYNKVPA
160 170 180 190 200
RSAMRNTVNP SGSNDPFNNS TSLRKMLANP HFNAKDFVHD KLGNASAITI
210 220 230 240 250
DKFTSNLTDL SIQVQEEVKL NINKSYNEIM TVNNDLNVAM LELKRVRANI
260 270 280 290 300
NDLNEVLDQC TKIAEKRLQL QDQIDQERQG NFNNVESHSN SPALLPPLKA
310 320 330 340 350
GQNGNLMRRD RSSVLILEKF WDTELDQLFK NVEGAQKFIN STKGRHILMN
360 370 380 390 400
SANWMELNTT TGKPLQMVQI FILNDLVLIA DKSRDKQNDF IVSQCYPLKD
410 420 430 440 450
VTVTQEEFST KRLLFKFSNS NSSLYECRDA DECSRLLDVI RKAKDDLCDI
460 470 480 490 500
FHVEEENSKR IRESFRYLQS TQQTPGRENN RSPNKNKRRS MGGSITPGRN
510 520 530 540 550
VTGAMDQYLL QNLTLSMHSR PRSRDMSSTA QRLKFLDEGV EEIDIELARL
560 570 580 590 600
RFESAVETLL DIESQLEDLS ERISDEELML LNLISLKIEQ RREAISSKLS
610 620 630 640 650
QSILSSNEIV HLKSGTENMI KLGLPEQALD LFLQNRSNFI QDLILQIGSV
660 670 680 690 700
DNPTNYLTQL AVIRFQTIKK TVEDFQDIFK ELGAKISSIL VDWCSDEVDN
710 720 730 740 750
HFKLIDKQLL NDEMLSPGSI KSSRKQIDGL KAVGLDFVYK LDEFIKKNSD
KIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78993 Genomic DNA Translation: CAA55605.1 Z35971 Genomic DNA Translation: CAA85057.1 BK006936 Genomic DNA Translation: DAA07221.1 |
PIRi | S48267 |
RefSeqi | NP_009660.1, NM_001178450.1 |
Genome annotation databases
EnsemblFungii | YBR102C_mRNA; YBR102C; YBR102C |
GeneIDi | 852398 |
KEGGi | sce:YBR102C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78993 Genomic DNA Translation: CAA55605.1 Z35971 Genomic DNA Translation: CAA85057.1 BK006936 Genomic DNA Translation: DAA07221.1 |
PIRi | S48267 |
RefSeqi | NP_009660.1, NM_001178450.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2D2S | X-ray | 2.85 | A | 523-753 | [»] | |
5YFP | electron microscopy | 4.40 | H | 1-753 | [»] | |
6VKL | electron microscopy | 4.40 | H | 1-753 | [»] | |
SMRi | P38261 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32806, 318 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-2732N |
IntActi | P38261, 19 interactors |
MINTi | P38261 |
STRINGi | 4932.YBR102C |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
PTM databases
iPTMneti | P38261 |
Proteomic databases
MaxQBi | P38261 |
PaxDbi | P38261 |
PRIDEi | P38261 |
Genome annotation databases
EnsemblFungii | YBR102C_mRNA; YBR102C; YBR102C |
GeneIDi | 852398 |
KEGGi | sce:YBR102C |
Organism-specific databases
SGDi | S000000306, EXO84 |
VEuPathDBi | FungiDB:YBR102C |
Phylogenomic databases
eggNOGi | KOG2215, Eukaryota |
GeneTreei | ENSGT00390000015936 |
HOGENOMi | CLU_014732_0_0_1 |
InParanoidi | P38261 |
OMAi | FKILMFP |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29064-MONOMER |
Reactomei | R-SCE-264876, Insulin processing |
Miscellaneous databases
EvolutionaryTracei | P38261 |
PROi | PR:P38261 |
RNActi | P38261, protein |
Family and domain databases
Gene3Di | 1.20.58.1210, 1 hit 1.20.58.1220, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR016159, Cullin_repeat-like_dom_sf IPR033961, Exo84 IPR032403, Exo84_C IPR042561, Exo84_C_1 IPR042560, Exo84_C_2 IPR011993, PH-like_dom_sf |
PANTHERi | PTHR21426, PTHR21426, 1 hit |
Pfami | View protein in Pfam PF16528, Exo84_C, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EXO84_YEAST | |
Accessioni | P38261Primary (citable) accession number: P38261 Secondary accession number(s): D6VQA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names