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Entry version 158 (13 Feb 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Probable tubulin--tyrosine ligase PBY1

Gene

PBY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable P-body-associated tubulin--tyrosine ligase.By similarity1 Publication

Miscellaneous

Present with 1770 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandMagnesium, Potassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29058-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-8955332 Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable tubulin--tyrosine ligase PBY1 (EC:6.3.2.25)
Alternative name(s):
P-body-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBY1
Ordered Locus Names:YBR094W
ORF Names:YBR0821
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YBR094W

Saccharomyces Genome Database

More...
SGDi
S000000298 PBY1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124481 – 753Probable tubulin--tyrosine ligase PBY1Add BLAST753

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38254

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38254

PRoteomics IDEntifications database

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PRIDEi
P38254

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38254

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32800, 78 interactors

Database of interacting proteins

More...
DIPi
DIP-1585N

Protein interaction database and analysis system

More...
IntActi
P38254, 7 interactors

Molecular INTeraction database

More...
MINTi
P38254

STRING: functional protein association networks

More...
STRINGi
4932.YBR094W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P38254

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini343 – 734TTLPROSITE-ProRule annotationAdd BLAST392

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164409

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38254

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKAHMIG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002828 SurE-like_Pase/nucleotidase
IPR027746 TTL
IPR004344 TTL/TTLL_fam

The PANTHER Classification System

More...
PANTHERi
PTHR30457:SF8 PTHR30457:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01975 SurE, 1 hit
PF03133 TTL, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00087 surE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221 TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLITNDDG PLSDQFSPYI RPFIQHIKRN YPEWKITVCV PHVQKSWVGK
60 70 80 90 100
AHLAGKNLTA QFIYSKVDAE DNTFWGPFIQ PQIRSENSKL PYVLNAEIPK
110 120 130 140 150
DTIEWILIDG TPASCANIGL HLLSNEPFDL VLSGPNVGRN TSAAYITSSG
160 170 180 190 200
TVGGAMESVI TGNTKAIAIS WAYFNGLKNV SPLLMEKASK RSLDVIKHLV
210 220 230 240 250
KNWDPKTDLY SINIPLVESL SDDTKVYYAP IWENRWIPIF NGPHINLENS
260 270 280 290 300
FAEIEDGNES SSISFNWAPK FGAHKDSIHY MDEYKDRTVL TDAEVIESEM
310 320 330 340 350
ISVTPMKATF KGVNHLLGEL KLTEEENNLS KTNNLIVVSI DPMEYIYKPL
360 370 380 390 400
THALKKYLPQ VEIVSNLPEF DNGGCEKEMK VFHYGDYEQL DMDKLMELPN
410 420 430 440 450
NYFTNSYIYR KALIRKHFLS HTIQTYTAKN PESILKKAYL ESFTIDLDYA
460 470 480 490 500
EFLDDALDEN WELRQELENE SQDKWWIVKP SMSDKGQGIR VFKTIEDLQA
510 520 530 540 550
IFDSFDDEDS EAEESGNDDD ADDVNGEFMD NNKVNISQLR HFIIQEYLTN
560 570 580 590 600
PLLLASMDNR KFHIRCYVVC RGDLQVFVYD RMLALFAAKP FVPLDPYAYS
610 620 630 640 650
VTDLKDLECH LTNTCLQSKK KDKDSSVLEF DSIEEIPNER KSNIKEQIHS
660 670 680 690 700
ITNDVFLAAV NVNRLNFQPL PNAFETYGVD FLIDSNYEVK LLEINAFPDF
710 720 730 740 750
KQTGKDLKNL IDELFDDTVK YCVTPIFNEN RNKTDDETDP NFVKVIDYTS

NGW
Length:753
Mass (Da):86,353
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i925C4E4CAB6679E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti352 – 355HALK → TPE in CAA49508 (Ref. 4) Curated4
Sequence conflicti450A → R in CAA55599 (PubMed:7900426).Curated1
Sequence conflicti450A → R in CAA85047 (PubMed:7813418).Curated1
Sequence conflicti563H → R in CAA49508 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X78993 Genomic DNA Translation: CAA55599.1
Z35963 Genomic DNA Translation: CAA85047.1
X69881 Genomic DNA Translation: CAA49508.1
BK006936 Genomic DNA Translation: DAA07215.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S48261

NCBI Reference Sequences

More...
RefSeqi
NP_009652.2, NM_001178442.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR094W_mRNA; YBR094W_mRNA; YBR094W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852391

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR094W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78993 Genomic DNA Translation: CAA55599.1
Z35963 Genomic DNA Translation: CAA85047.1
X69881 Genomic DNA Translation: CAA49508.1
BK006936 Genomic DNA Translation: DAA07215.2
PIRiS48261
RefSeqiNP_009652.2, NM_001178442.2

3D structure databases

ProteinModelPortaliP38254
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32800, 78 interactors
DIPiDIP-1585N
IntActiP38254, 7 interactors
MINTiP38254
STRINGi4932.YBR094W

PTM databases

iPTMnetiP38254

Proteomic databases

MaxQBiP38254
PaxDbiP38254
PRIDEiP38254

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR094W_mRNA; YBR094W_mRNA; YBR094W
GeneIDi852391
KEGGisce:YBR094W

Organism-specific databases

EuPathDBiFungiDB:YBR094W
SGDiS000000298 PBY1

Phylogenomic databases

GeneTreeiENSGT00940000164409
InParanoidiP38254
OMAiGKAHMIG

Enzyme and pathway databases

BioCyciYEAST:G3O-29058-MONOMER
ReactomeiR-SCE-8955332 Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38254

Family and domain databases

InterProiView protein in InterPro
IPR002828 SurE-like_Pase/nucleotidase
IPR027746 TTL
IPR004344 TTL/TTLL_fam
PANTHERiPTHR30457:SF8 PTHR30457:SF8, 1 hit
PfamiView protein in Pfam
PF01975 SurE, 1 hit
PF03133 TTL, 1 hit
TIGRFAMsiTIGR00087 surE, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTL_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38254
Secondary accession number(s): D6VQ95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: February 13, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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