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UniProtKB - P38227 (QDR3_YEAST)
Protein
Quinidine resistance protein 3
Gene
QDR3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).
1 PublicationMiscellaneous
Present with 279 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- efflux transmembrane transporter activity Source: SGD
- polyamine transmembrane transporter activity Source: SGD
- xenobiotic transmembrane transporter activity Source: GO_Central
GO - Biological processi
- ascospore wall assembly Source: SGD
- polyamine homeostasis Source: SGD
- transmembrane transport Source: SGD
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: GO_Central
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.1.2.43, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Quinidine resistance protein 3Alternative name(s): Acids quinidine resistance protein 2 |
Gene namesi | Name:QDR3 Synonyms:AQR2 Ordered Locus Names:YBR043C ORF Names:YBR0413 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000247, QDR3 |
VEuPathDBi | FungiDB:YBR043C |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Plasma Membrane
- plasma membrane Source: SGD
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 108 | ExtracellularSequence analysisAdd BLAST | 108 | |
Transmembranei | 109 – 131 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 132 – 139 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 140 – 163 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 164 – 175 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 176 – 193 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 194 – 235 | CytoplasmicSequence analysisAdd BLAST | 42 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 265 | ExtracellularSequence analysis | 9 | |
Transmembranei | 266 – 283 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 284 – 475 | CytoplasmicSequence analysisAdd BLAST | 192 | |
Transmembranei | 476 – 493 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 494 – 510 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 511 – 532 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 533 – 558 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 559 – 577 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 578 – 586 | ExtracellularSequence analysis | 9 | |
Transmembranei | 587 – 609 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 610 – 624 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 625 – 642 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 643 – 648 | ExtracellularSequence analysis | 6 | |
Transmembranei | 649 – 668 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 669 – 689 | CytoplasmicSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173437 | 1 – 689 | Quinidine resistance protein 3Add BLAST | 689 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 436 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P38227 |
PaxDbi | P38227 |
PRIDEi | P38227 |
PTM databases
iPTMneti | P38227 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 32744, 67 interactors |
DIPi | DIP-797N |
IntActi | P38227, 3 interactors |
MINTi | P38227 |
STRINGi | 4932.YBR043C |
Miscellaneous databases
RNActi | P38227, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 73 | DisorderedSequence analysisAdd BLAST | 73 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 31 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 55 – 73 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
HOGENOMi | CLU_008455_8_5_1 |
InParanoidi | P38227 |
OMAi | MLIVMRL |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P38227-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGSPHS EHNDYSYEKT
60 70 80 90 100
NLESTASNSR EHRDNQLSRL KSEEYVVPKN QRRGLLPQLA IIPEFKDARD
110 120 130 140 150
YPPMMKKMIV FLIAFSSMMG PMGTSIIFPA INSITTEFKT SVIMVNVSIG
160 170 180 190 200
VYLLSLGVFP LWWSSLSELE GRRTTYITSF ALLFAFNIGS ALAPDINSFI
210 220 230 240 250
ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG PLLAPLLSPI
260 270 280 290 300
FGSLLVNRWP WRSTQWFMVI LSGCNVILLT VLLPETLRKQ DSKGAIAQIL
310 320 330 340 350
AERRIQVDNN ERGEIQEDYQ RGEDETDRIE NQVATLSTEK HNYVGEVRDQ
360 370 380 390 400
DSLDLESHSS PNTYDGRAGE TQLQRIYTEA SRSLYEYQLD DSGIDATTAQ
410 420 430 440 450
VTRIRSTDPK LARSIRENSL RKLQTNLEEQ VKKVLSSNGG EIAPKQVSAV
460 470 480 490 500
RKVWDTFFVY FIKPLKSLHF LEYPPVALAI TFSAISFSTV YFVNMTVEYK
510 520 530 540 550
YSRPPYNFKP LYIGLLYIPN SVTYFFASIY GGRWVDMLLK RYKEKYGILA
560 570 580 590 600
PEARISWNVV TSVISFPIAL LIFGWCLDKK CHWVTPLIGT ALFGYAAMMT
610 620 630 640 650
IGATLSYLVD SLPGKGATGV ALNNLIRQIL AATAVFVTTP MLNGMGTGWA
660 670 680
FTMLAFIVLG ASSVLIILKK HGDYWRENYD LQKLYDKID
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | S → T in CAA84985 (PubMed:7813418).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z35912 Genomic DNA Translation: CAA84985.1 BK006936 Genomic DNA Translation: DAA07163.2 |
PIRi | S45901 |
RefSeqi | NP_009599.2, NM_001178391.2 |
Genome annotation databases
EnsemblFungii | YBR043C_mRNA; YBR043C; YBR043C |
GeneIDi | 852331 |
KEGGi | sce:YBR043C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z35912 Genomic DNA Translation: CAA84985.1 BK006936 Genomic DNA Translation: DAA07163.2 |
PIRi | S45901 |
RefSeqi | NP_009599.2, NM_001178391.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 32744, 67 interactors |
DIPi | DIP-797N |
IntActi | P38227, 3 interactors |
MINTi | P38227 |
STRINGi | 4932.YBR043C |
Protein family/group databases
TCDBi | 2.A.1.2.43, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | P38227 |
Proteomic databases
MaxQBi | P38227 |
PaxDbi | P38227 |
PRIDEi | P38227 |
Genome annotation databases
EnsemblFungii | YBR043C_mRNA; YBR043C; YBR043C |
GeneIDi | 852331 |
KEGGi | sce:YBR043C |
Organism-specific databases
SGDi | S000000247, QDR3 |
VEuPathDBi | FungiDB:YBR043C |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
HOGENOMi | CLU_008455_8_5_1 |
InParanoidi | P38227 |
OMAi | MLIVMRL |
Miscellaneous databases
PROi | PR:P38227 |
RNActi | P38227, protein |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QDR3_YEAST | |
Accessioni | P38227Primary (citable) accession number: P38227 Secondary accession number(s): D6VQ43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 27, 2011 | |
Last modified: | September 29, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - SIMILARITY comments
Index of protein domains and families