Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Very long-chain fatty acid transport protein

Gene

FAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised.

Miscellaneous

Present with 16900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • long-chain fatty acid transporter activity Source: SGD
  • very long-chain fatty acid-CoA ligase activity Source: SGD

GO - Biological processi

  • long-chain fatty acid import Source: SGD
  • very long-chain fatty acid metabolic process Source: SGD

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:YBR041W-MONOMER
BRENDAi6.2.1.3 984
ReactomeiR-SCE-159418 Recycling of bile acids and salts
R-SCE-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-SCE-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-SCE-389599 Alpha-oxidation of phytanate
R-SCE-6798695 Neutrophil degranulation
R-SCE-804914 Transport of fatty acids
R-SCE-9033241 Peroxisomal protein import

Protein family/group databases

TCDBi4.C.1.1.2 the fatty acid transporter (fat) family

Chemistry databases

SwissLipidsiSLP:000000129

Names & Taxonomyi

Protein namesi
Recommended name:
Very long-chain fatty acid transport protein
Gene namesi
Name:FAT1
Ordered Locus Names:YBR041W
ORF Names:YBR0411
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR041W
SGDiS000000245 FAT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei54 – 71HelicalSequence analysisAdd BLAST18
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931811 – 669Very long-chain fatty acid transport proteinAdd BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38225
PaxDbiP38225
PRIDEiP38225

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSA2P105922EBI-6819,EBI-8603

Protein-protein interaction databases

BioGridi32742, 212 interactors
DIPiDIP-5048N
IntActiP38225, 17 interactors
MINTiP38225
STRINGi4932.YBR041W

Structurei

3D structure databases

ProteinModelPortaliP38225
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074420
HOGENOMiHOG000044189
InParanoidiP38225
OMAiFQGYYGN
OrthoDBiEOG092C0XV9

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P38225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY
60 70 80 90 100
KEDWYIIPYF LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP
110 120 130 140 150
MAEKGEFQLE TFTYIETYNI VLRLSHILHF DYNVQAGDYV AIDCTNKPLF
160 170 180 190 200
VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL KISNITQVFI DPDASNPIRE
210 220 230 240 250
SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV RTPLGLTDFK
260 270 280 290 300
PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF
310 320 330 340 350
HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR
360 370 380 390 400
YLLHTPISKY EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA
410 420 430 440 450
PFATTTFQKG DFGIGACRNY GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK
460 470 480 490 500
GFCEVAPVGE PGEMLMRIFF PKKPETSFQG YLGNAKETKS KVVRDVFRRG
510 520 530 540 550
DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV EDQLTASNKE
560 570 580 590 600
QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP
610 620 630 640 650
SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR
660
YEVLTAADWE AIDAQTIKL
Length:669
Mass (Da):77,141
Last modified:August 31, 2004 - v2
Checksum:i509A5DEDDEE98823
GO

Sequence cautioni

The sequence CAA84983 differs from that shown. Reason: Frameshift at position 620.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065148 Genomic DNA Translation: AAC17118.1
Z35910 Genomic DNA Translation: CAA84983.1 Frameshift.
AY260890 Genomic DNA Translation: AAP21758.1
BK006936 Genomic DNA Translation: DAA07161.1
PIRiS45899
RefSeqiNP_009597.2, NM_001178389.1

Genome annotation databases

EnsemblFungiiYBR041W; YBR041W; YBR041W
GeneIDi852329
KEGGisce:YBR041W

Similar proteinsi

Entry informationi

Entry nameiFAT1_YEAST
AccessioniPrimary (citable) accession number: P38225
Secondary accession number(s): D6VQ41, O60021, Q86ZS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 31, 2004
Last modified: July 18, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health