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UniProtKB - P38222 (RKM3_YEAST)
Protein
Ribosomal lysine N-methyltransferase 3
Gene
RKM3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-40'.
2 PublicationsMiscellaneous
Present with 7880 molecules/cell in log phase SD medium.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 334 | S-adenosyl-L-methioninePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein-lysine N-methyltransferase activity Source: SGD
GO - Biological processi
- peptidyl-lysine monomethylation Source: SGD
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
Reactomei | R-SCE-3214841, PKMTs methylate histone lysines |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RKM31 Publication Ordered Locus Names:YBR030WImported ORF Names:YBR0314 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000234, RKM3 |
VEuPathDBi | FungiDB:YBR030W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202472 | 1 – 552 | Ribosomal lysine N-methyltransferase 3Add BLAST | 552 |
Proteomic databases
MaxQBi | P38222 |
PaxDbi | P38222 |
PRIDEi | P38222 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 32732, 106 interactors |
IntActi | P38222, 4 interactors |
MINTi | P38222 |
STRINGi | 4932.YBR030W |
Miscellaneous databases
RNActi | P38222, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 335 | SETPROSITE-ProRule annotationAdd BLAST | 310 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 399 – 432 | DisorderedSequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG1337, Eukaryota |
GeneTreei | ENSGT00940000153577 |
HOGENOMi | CLU_033565_1_0_1 |
InParanoidi | P38222 |
OMAi | FIYETTV |
Family and domain databases
InterProi | View protein in InterPro IPR001214, SET_dom |
Pfami | View protein in Pfam PF00856, SET, 1 hit |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit |
i Sequence
Sequence statusi: Complete.
P38222-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVTFKDDVH RILKFVANCN GRFEDSKCDI RESPLGGLGV FAKTDIAEGE
60 70 80 90 100
SILTLNKSSI FSASNSSIAN LLCDSSIDGM LALNIAFIYE TTVFRNSSHW
110 120 130 140 150
YPFLRTIRIR DDEGHLNLPP SFWHADAKRL LKGTSFDTLF DSLAPEEEIM
160 170 180 190 200
EGFEIAVDLA HKWNDEFGLE IPKGFLDVSE ENHEEDYNLK LEKFISVAYT
210 220 230 240 250
LSSRGFEIDA YHETALVPIA DLFNHHVSDP DLKFVSLYDV CDKCGEPDMC
260 270 280 290 300
KHLIAEEYLE AENLDKNMPK VASMETRVID EDLIKSLEND LEKEYSNVTA
310 320 330 340 350
NIEDDDGGIE NPDECVDLVL KNDVAQGQEI FNSYGELSNV FLLARYGFTV
360 370 380 390 400
PENQYDIVHL GPDFMKILKK EEKYQEKVKW WSQVGHGLFS AWYAQMRQED
410 420 430 440 450
EEDEDGQAKS DNLSDDIESE EEEEEEEGDD SLESWLSQLY IDSSGEPSPS
460 470 480 490 500
TWALANLLTL TAVQWESLFS KKATPHISDS IVNEEKLPFL AKKDNPHSKK
510 520 530 540 550
LLSNLLKEKQ LPCIKGDNSS KITSATKSML QNARTLVQSE HNILDRCLKR
LS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z35899 Genomic DNA Translation: CAA84972.1 X76078 Genomic DNA Translation: CAA53686.1 BK006936 Genomic DNA Translation: DAA07151.1 |
PIRi | S45886 |
RefSeqi | NP_009586.1, NM_001178378.1 |
Genome annotation databases
EnsemblFungii | YBR030W_mRNA; YBR030W; YBR030W |
GeneIDi | 852318 |
KEGGi | sce:YBR030W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z35899 Genomic DNA Translation: CAA84972.1 X76078 Genomic DNA Translation: CAA53686.1 BK006936 Genomic DNA Translation: DAA07151.1 |
PIRi | S45886 |
RefSeqi | NP_009586.1, NM_001178378.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 32732, 106 interactors |
IntActi | P38222, 4 interactors |
MINTi | P38222 |
STRINGi | 4932.YBR030W |
Proteomic databases
MaxQBi | P38222 |
PaxDbi | P38222 |
PRIDEi | P38222 |
Genome annotation databases
EnsemblFungii | YBR030W_mRNA; YBR030W; YBR030W |
GeneIDi | 852318 |
KEGGi | sce:YBR030W |
Organism-specific databases
SGDi | S000000234, RKM3 |
VEuPathDBi | FungiDB:YBR030W |
Phylogenomic databases
eggNOGi | KOG1337, Eukaryota |
GeneTreei | ENSGT00940000153577 |
HOGENOMi | CLU_033565_1_0_1 |
InParanoidi | P38222 |
OMAi | FIYETTV |
Enzyme and pathway databases
Reactomei | R-SCE-3214841, PKMTs methylate histone lysines |
Miscellaneous databases
PROi | PR:P38222 |
RNActi | P38222, protein |
Family and domain databases
InterProi | View protein in InterPro IPR001214, SET_dom |
Pfami | View protein in Pfam PF00856, SET, 1 hit |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RKM3_YEAST | |
Accessioni | P38222Primary (citable) accession number: P38222 Secondary accession number(s): D6VQ31 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - SIMILARITY comments
Index of protein domains and families