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Entry version 172 (29 Sep 2021)
Sequence version 1 (01 Oct 1994)
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Protein

Importin subunit beta-2

Gene

KAP104

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Required for nuclear transport of NAB2, HRP1/NAB4 and TFG2. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins (PubMed:8849456, PubMed:9488461, PubMed:10506153, PubMed:19366694).

The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015).

At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. Efficient GTP-Ran-mediated substrate release requires RNA (PubMed:10506153).

The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015).

1 Publication4 Publications

Miscellaneous

Binds to nucleoporin FxFG but not PSFG repeat regions.1 Publication
Present with 2130 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Importin subunit beta-2By similarity
Alternative name(s):
Importin-104
Karyopherin subunit beta-2
Karyopherin-1041 Publication
TransportinBy similarity
Short name:
TRNBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KAP1041 Publication
Ordered Locus Names:YBR017CImported
ORF Names:YBR0224
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000221, KAP104

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YBR017C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207701 – 918Importin subunit beta-2Add BLAST918

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38217

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38217

PRoteomics IDEntifications database

More...
PRIDEi
P38217

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Ran (GSP1) (PubMed:9321403, PubMed:10506153); interacts specifically with the GTP-bound form of Ran (GTP-Ran), protecting it from GTP hydrolysis and nucleotide exchange (PubMed:9321403).

Interacts with nucleoporins NUP1, NUP100 and NUP116 (PubMed:8849456).

Interacts with NAB2 and HRP1/NAB4; via their rg-NLS (PubMed:9488461, PubMed:10506153).

Interacts with TFG2; via its PY-NLS (PubMed:19366694).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32720, 245 interactors

Database of interacting proteins

More...
DIPi
DIP-1399N

Protein interaction database and analysis system

More...
IntActi
P38217, 110 interactors

Molecular INTeraction database

More...
MINTi
P38217

STRING: functional protein association networks

More...
STRINGi
4932.YBR017C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38217, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P38217

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati11 – 38HEAT 1By similarityAdd BLAST28
Repeati43 – 92HEAT 2By similarityAdd BLAST50
Repeati103 – 137HEAT 3By similarityAdd BLAST35
Repeati145 – 181HEAT 4By similarityAdd BLAST37
Repeati190 – 222HEAT 5By similarityAdd BLAST33
Repeati235 – 263HEAT 6By similarityAdd BLAST29
Repeati275 – 303HEAT 7By similarityAdd BLAST29
Repeati320 – 413HEAT 8By similarityAdd BLAST94
Repeati421 – 449HEAT 9By similarityAdd BLAST29
Repeati461 – 488HEAT 10By similarityAdd BLAST28
Repeati501 – 534HEAT 11By similarityAdd BLAST34
Repeati542 – 577HEAT 12By similarityAdd BLAST36
Repeati583 – 620HEAT 13By similarityAdd BLAST38
Repeati628 – 678HEAT 14By similarityAdd BLAST51
Repeati694 – 725HEAT 15By similarityAdd BLAST32
Repeati777 – 814HEAT 17By similarityAdd BLAST38
Repeati825 – 858HEAT 18By similarityAdd BLAST34
Repeati867 – 900HEAT 19By similarityAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni361 – 395DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi375 – 393Acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2023, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174661

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008136_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38217

Identification of Orthologs from Complete Genome Data

More...
OMAi
INVFTPR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR040122, Importin_beta

The PANTHER Classification System

More...
PANTHERi
PTHR10527, PTHR10527, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985, HEAT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38217-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTWKPAED YVLQLATLLQ NCMSPNPEIR NNAMEAMENF QLQPEFLNYL
60 70 80 90 100
CYILIEGESD DVLKQHYSLQ DLQNNRATAG MLLKNSMLGG NNLIKSNSHD
110 120 130 140 150
LGYVKSNIIH GLYNSNNNLV SNVTGIVITT LFSTYYRQHR DDPTGLQMLY
160 170 180 190 200
QLLELTSNGN EPSIKALSKI MEDSAQFFQL EWSGNTKPME ALLDSFFRFI
210 220 230 240 250
SNPNFSPVIR SESVKCINTV IPLQTQSFIV RLDKFLEIIF QLAQNDENDL
260 270 280 290 300
VRAQICISFS FLLEFRPDKL VSHLDGIVQF MLHLITTVNE EKVAIEACEF
310 320 330 340 350
LHAFATSPNI PEHILQPYVK DIVPILLSKM VYNEESIVLL EASNDDDAFL
360 370 380 390 400
EDKDEDIKPI APRIVKKKEA GNGEDADDNE DDDDDDDDED GDVDTQWNLR
410 420 430 440 450
KCSAATLDVM TNILPHQVMD IAFPFLREHL GSDRWFIREA TILALGAMAE
460 470 480 490 500
GGMKYFNDGL PALIPFLVEQ LNDKWAPVRK MTCWTLSRFS PWILQDHTEF
510 520 530 540 550
LIPVLEPIIN TLMDKKKDVQ EAAISSVAVF IENADSELVE TLFYSQLLTS
560 570 580 590 600
FDKCLKYYKK KNLIILYDAI GRFAEKCALD ETAMQIILPP LIEKWALLSD
610 620 630 640 650
SDKELWPLLE CLSCVASSLG ERFMPMAPEV YNRAFRILCH CVELEAKSHQ
660 670 680 690 700
DPTIVVPEKD FIITSLDLID GLVQGLGAHS QDLLFPQGTK DLTILKIMLE
710 720 730 740 750
CLQDPVHEVR QSCFALLGDI VYFFNSELVI GNLEDFLKLI GTEIMHNDDS
760 770 780 790 800
DGTPAVINAI WALGLISERI DLNTYIIDMS RIILDLFTTN TQIVDSSVME
810 820 830 840 850
NLSVTIGKMG LTHPEVFSSG AFANDSNWNK WCLSVNALDD VEEKSSAYMG
860 870 880 890 900
FLKIINLTST EVTMSNDTIH KIVTGLSSNV EANVFAQEIY TFLMNHSAQI
910
SAINFTPDEI SFLQQFTS
Length:918
Mass (Da):103,681
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8010A477D1FC0B5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X81324 Genomic DNA Translation: CAA57104.1
Z35886 Genomic DNA Translation: CAA84959.1
BK006936 Genomic DNA Translation: DAA07139.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45872

NCBI Reference Sequences

More...
RefSeqi
NP_009573.1, NM_001178365.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR017C_mRNA; YBR017C; YBR017C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852305

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR017C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81324 Genomic DNA Translation: CAA57104.1
Z35886 Genomic DNA Translation: CAA84959.1
BK006936 Genomic DNA Translation: DAA07139.1
PIRiS45872
RefSeqiNP_009573.1, NM_001178365.1

3D structure databases

SMRiP38217
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32720, 245 interactors
DIPiDIP-1399N
IntActiP38217, 110 interactors
MINTiP38217
STRINGi4932.YBR017C

Proteomic databases

MaxQBiP38217
PaxDbiP38217
PRIDEiP38217

Genome annotation databases

EnsemblFungiiYBR017C_mRNA; YBR017C; YBR017C
GeneIDi852305
KEGGisce:YBR017C

Organism-specific databases

SGDiS000000221, KAP104
VEuPathDBiFungiDB:YBR017C

Phylogenomic databases

eggNOGiKOG2023, Eukaryota
GeneTreeiENSGT00940000174661
HOGENOMiCLU_008136_1_1_1
InParanoidiP38217
OMAiINVFTPR

Enzyme and pathway databases

ReactomeiR-SCE-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38217
RNActiP38217, protein

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR040122, Importin_beta
PANTHERiPTHR10527, PTHR10527, 1 hit
PfamiView protein in Pfam
PF02985, HEAT, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMB2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38217
Secondary accession number(s): D6VQ19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 29, 2021
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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