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Entry version 162 (23 Feb 2022)
Sequence version 1 (01 Oct 1994)
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Protein

Oligosaccharide translocation protein RFT1

Gene

RFT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in N-linked oligosaccharide assembly. Required for the translocation of Man5GlcNAc2-PP-dolichol from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSugar transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.66.3.1, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oligosaccharide translocation protein RFT1
Alternative name(s):
Requiring fifty-three protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RFT1
Ordered Locus Names:YBL020W
ORF Names:YBL0442
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000116, RFT1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YBL020W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24LumenalSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 48CytoplasmicSequence analysis3
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 110LumenalSequence analysisAdd BLAST41
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 148CytoplasmicSequence analysisAdd BLAST17
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 181LumenalSequence analysisAdd BLAST12
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 218CytoplasmicSequence analysisAdd BLAST16
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 319LumenalSequence analysisAdd BLAST80
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 372CytoplasmicSequence analysisAdd BLAST32
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 413LumenalSequence analysisAdd BLAST20
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 443CytoplasmicSequence analysis9
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 469LumenalSequence analysis5
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 509CytoplasmicSequence analysisAdd BLAST19
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 532LumenalSequence analysis2
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Topological domaini554 – 574CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124201 – 574Oligosaccharide translocation protein RFT1Add BLAST574

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38206

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38206

PRoteomics IDEntifications database

More...
PRIDEi
P38206

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38206

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
32678, 535 interactors

Database of interacting proteins

More...
DIPi
DIP-3885N

Protein interaction database and analysis system

More...
IntActi
P38206, 5 interactors

Molecular INTeraction database

More...
MINTi
P38206

STRING: functional protein association networks

More...
STRINGi
4932.YBL020W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38206, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P38206

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RFT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2864, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011390

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023360_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38206

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANNYGGL

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007594, RFT1

The PANTHER Classification System

More...
PANTHERi
PTHR13117, PTHR13117, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04506, Rft-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38206-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKKNSQLPS TSEQILERST TGATFLMMGQ LFTKLVTFIL NNLLIRFLSP
60 70 80 90 100
RIFGITAFLE FIQGTVLFFS RDAIRLSTLR ISDSGNGIID DDDEEEYQET
110 120 130 140 150
HYKSKVLQTA VNFAYIPFWI GFPLSIGLIA WQYRNINAYF ITLPFFRWSI
160 170 180 190 200
FLIWLSIIVE LLSEPFFIVN QFMLNYAARS RFESIAVTTG CIVNFIVVYA
210 220 230 240 250
VQQSRYPMGV VTSDIDKEGI AILAFALGKL AHSITLLACY YWDYLKNFKP
260 270 280 290 300
KKLFSTRLTK IKTRENNELK KGYPKSTSYF FQNDILQHFK KVYFQLCFKH
310 320 330 340 350
LLTEGDKLII NSLCTVEEQG IYALLSNYGS LLTRLLFAPI EESLRLFLAR
360 370 380 390 400
LLSSHNPKNL KLSIEVLVNL TRFYIYLSLM IIVFGPANSS FLLQFLIGSK
410 420 430 440 450
WSTTSVLDTI RVYCFYIPFL SLNGIFEAFF QSVATGDQIL KHSYFMMAFS
460 470 480 490 500
GIFLLNSWLL IEKLKLSIEG LILSNIINMV LRILYCGVFL NKFHRELFTD
510 520 530 540 550
SSFFFNFKDF KTVIIAGSTI CLLDWWFIGY VKNLQQFVVN VLFAMGLLAL
560 570
ILVKERQTIQ SFINKRAVSN SKDV
Length:574
Mass (Da):66,211
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD619A5362FB65509
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74 – 75IR → MF in AAA53537 (PubMed:2832732).Curated2
Sequence conflicti207 – 216PMGVVTSDID → QWGLSHRTLT in AAA53537 (PubMed:2832732).Curated10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U15087 Genomic DNA Translation: AAA86312.1
Z35781 Genomic DNA Translation: CAA84839.1
M20318 Genomic DNA Translation: AAA53537.1
BK006936 Genomic DNA Translation: DAA07100.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45754

NCBI Reference Sequences

More...
RefSeqi
NP_009533.1, NM_001178260.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBL020W_mRNA; YBL020W; YBL020W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852261

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBL020W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15087 Genomic DNA Translation: AAA86312.1
Z35781 Genomic DNA Translation: CAA84839.1
M20318 Genomic DNA Translation: AAA53537.1
BK006936 Genomic DNA Translation: DAA07100.1
PIRiS45754
RefSeqiNP_009533.1, NM_001178260.1

3D structure databases

SMRiP38206
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi32678, 535 interactors
DIPiDIP-3885N
IntActiP38206, 5 interactors
MINTiP38206
STRINGi4932.YBL020W

Protein family/group databases

TCDBi2.A.66.3.1, the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

PTM databases

iPTMnetiP38206

Proteomic databases

MaxQBiP38206
PaxDbiP38206
PRIDEiP38206

Genome annotation databases

EnsemblFungiiYBL020W_mRNA; YBL020W; YBL020W
GeneIDi852261
KEGGisce:YBL020W

Organism-specific databases

SGDiS000000116, RFT1
VEuPathDBiFungiDB:YBL020W

Phylogenomic databases

eggNOGiKOG2864, Eukaryota
GeneTreeiENSGT00390000011390
HOGENOMiCLU_023360_3_0_1
InParanoidiP38206
OMAiANNYGGL

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38206
RNActiP38206, protein

Family and domain databases

InterProiView protein in InterPro
IPR007594, RFT1
PANTHERiPTHR13117, PTHR13117, 1 hit
PfamiView protein in Pfam
PF04506, Rft-1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFT1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38206
Secondary accession number(s): D6VPY0, Q05814
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 23, 2022
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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