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Entry version 139 (18 Sep 2019)
Sequence version 1 (01 Oct 1994)
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Protein

Protein STU1

Gene

STU1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for separation of the spindle poles during mitotic spindle formation. May cross-link overlapping antiparallel microtubules in the spindle midzone.2 Publications

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28936-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein STU1
Alternative name(s):
Suppressor of tubulin 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STU1
Ordered Locus Names:YBL034C
ORF Names:YBL0416
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YBL034C

Saccharomyces Genome Database

More...
SGDi
S000000130 STU1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722941 – 1513Protein STU1Add BLAST1513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei997PhosphoserineCombined sources1
Modified residuei1018PhosphoserineCombined sources1
Modified residuei1047PhosphothreonineCombined sources1
Modified residuei1063PhosphoserineCombined sources1
Modified residuei1167PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P38198

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P38198

PRoteomics IDEntifications database

More...
PRIDEi
P38198

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38198

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates.

Interacts with microtubules via the TUB2 subunit.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32663, 791 interactors

Database of interacting proteins

More...
DIPi
DIP-2633N

Protein interaction database and analysis system

More...
IntActi
P38198, 9 interactors

Molecular INTeraction database

More...
MINTi
P38198

STRING: functional protein association networks

More...
STRINGi
4932.YBL034C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11513
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38198

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni461 – 716Interaction with microtubulesAdd BLAST256

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLASP family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154446

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38198

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHNKLFQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348 CLASP_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFNNETNN NSNTNTHPDD SFPLYTVFKD ESVPIEEKMA LLTRFKGHVK
60 70 80 90 100
KELVNESSIQ AYFAALLFIS GHYAYRSYPR LIFLSHSSLC YLIKRVAMQS
110 120 130 140 150
PVQFNDTLVE QLLNHLIFEL PNEKKFWLAS IKAIEAIYLV NPSKIQAILA
160 170 180 190 200
NFLRRPSENQ NGDYLNRIKS TLLTIDELIQ INEKNNSNHL QLLRFFMLSF
210 220 230 240 250
TNLLNNNLNE HANDDNNNVI IELIFDIMYK YLKMDDENSQ DLIDGFINDL
260 270 280 290 300
EVEKFKQKFI SLAKSQDQHG SQEDKSTLFD EEYEFQLLLA EAKLPQLSNN
310 320 330 340 350
LSSKDPAMKK NYESLNQLQQ DLENLLAPFQ SVKETEQNWK LRQSNIIELD
360 370 380 390 400
NIISGNIPKD NPEEFVTVIK EVQLIELISR ATSSLRTTLS LTALLFLKRL
410 420 430 440 450
IHILNDQLPL SILDQIFVIF KNLLSSTKKI SSQTAFHCLI TLIIDINHFH
460 470 480 490 500
NKLFQLSFLL INEKTVTPRF CSAILLRSFL IKFNDSNLSL NNSNTTSPTS
510 520 530 540 550
KLENNIIYIE EWLKKGISDS QTTVREAMRL TFWYFYKCYP TNAKRLLSSS
560 570 580 590 600
FSPQLKKATE LAIPAHLNIN YQVSRVSSTA SASSATSRLY SHSSNNSSRK
610 620 630 640 650
TSLLEQKRNY PSYAQPTQSS STSLLNAPAV TAGGSVIASK LSNKLKTNLR
660 670 680 690 700
STSEYSSKEN EKRARHHDSM NSVSNSNTKD NNNVTKRKVS APPSSTAATK
710 720 730 740 750
VSENYTNFDD FPSNQIDLTD ELSNSYSNPL IKKYMDKNDV SMSSSPISLK
760 770 780 790 800
GSNKLGEYET LYKKFNDASF PAQIKDALQY LQKELLLTSQ QSSSAPKFEF
810 820 830 840 850
PMIMKKLRQI MIKSPNDFKP FLSIEKFTNG VPLNYLIELY SINSFDYAEI
860 870 880 890 900
LKNRMNPEKP YELTNLIITI ADLFNFLNAN NCPNDFKLYY MKYKTTFFNY
910 920 930 940 950
NFKLLLEIFR NLNIKHDNTL RSGTNDLMPK ISMILFQIYG KEFDYTCYFN
960 970 980 990 1000
LIFEIYKFDN NRFNKLLADF DIVSTKMKIC HELEKKDANF KVEDIISRES
1010 1020 1030 1040 1050
SVSFTPIDNK KSEGDEESDD AVDENDVKKC MEMTMINPFK NLETDKTLEL
1060 1070 1080 1090 1100
KNNVGKRTSS TDSVVIHDDN DKDKKLSEMT KIVSVYQLDQ PNPAKEEDDI
1110 1120 1130 1140 1150
DMENSQKSDL NLSEIFQNSG ENTERKLKDD NEPTVKFSTD PPKIINEPEK
1160 1170 1180 1190 1200
LIGNGNENEK PDLETMSPIK INGDENMGQK QRITVKRERD VALTEQDINS
1210 1220 1230 1240 1250
KKMKLVNNKK SEKMHLLIMD NFPRDSLTVY EISHLLMVDS NGNTLMDFDV
1260 1270 1280 1290 1300
YFNHMSKAIN RIKSGSFTMK HINYLIEPLI TCFQNQKMTD WLTNENGFDE
1310 1320 1330 1340 1350
LLDVAIMLLK STDDTPSIPS KISSKSIILV HCLLVWKKFL NTLSENADDD
1360 1370 1380 1390 1400
GVSVRMCFEE VWEQILLMLN KFSDYGNEIY KLAQEFRDSL MLSHFFKKHS
1410 1420 1430 1440 1450
ATRILSMLVT EIQPDTAGVK ETFLIETLWK MLQSPTICQQ FKKSNISEII
1460 1470 1480 1490 1500
QTMSYFIMGT DNTSWNFTSA VVLARCLRVL QTTPDYTEQE TERLFDCLPK
1510
NVFKMIMFIA SNE
Length:1,513
Mass (Da):174,177
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7F64B5A5D03588D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z35655 Genomic DNA Translation: CAA84714.1
Z35795 Genomic DNA Translation: CAA84854.1
X74738 Genomic DNA Translation: CAA52760.1
BK006936 Genomic DNA Translation: DAA07085.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45768

NCBI Reference Sequences

More...
RefSeqi
NP_009519.1, NM_001178274.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBL034C_mRNA; YBL034C; YBL034C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBL034C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35655 Genomic DNA Translation: CAA84714.1
Z35795 Genomic DNA Translation: CAA84854.1
X74738 Genomic DNA Translation: CAA52760.1
BK006936 Genomic DNA Translation: DAA07085.1
PIRiS45768
RefSeqiNP_009519.1, NM_001178274.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6COKX-ray1.89A249-567[»]
SMRiP38198
ModBaseiSearch...

Protein-protein interaction databases

BioGridi32663, 791 interactors
DIPiDIP-2633N
IntActiP38198, 9 interactors
MINTiP38198
STRINGi4932.YBL034C

PTM databases

iPTMnetiP38198

Proteomic databases

MaxQBiP38198
PaxDbiP38198
PRIDEiP38198

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL034C_mRNA; YBL034C; YBL034C
GeneIDi852246
KEGGisce:YBL034C

Organism-specific databases

EuPathDBiFungiDB:YBL034C
SGDiS000000130 STU1

Phylogenomic databases

HOGENOMiHOG000154446
InParanoidiP38198
OMAiFHNKLFQ

Enzyme and pathway databases

BioCyciYEAST:G3O-28936-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38198

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024395 CLASP_N_dom
PfamiView protein in Pfam
PF12348 CLASP_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTU1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38198
Secondary accession number(s): D6VPW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 18, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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