UniProtKB - P38170 (CND2_YEAST)
Protein
Condensin complex subunit 2
Gene
BRN1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.2 Publications
Miscellaneous
Present with 704 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- chromatin binding Source: SGD
- DNA topoisomerase binding Source: GO_Central
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- mitotic chromosome condensation Source: SGD
- mitotic sister chromatid segregation Source: SGD
- tRNA gene clustering Source: SGD
Keywordsi
Biological process | Cell cycle, Cell division, DNA condensation, Mitosis |
Enzyme and pathway databases
Reactomei | R-SCE-2514853, Condensation of Prometaphase Chromosomes |
Names & Taxonomyi
Protein namesi | Recommended name: Condensin complex subunit 2Alternative name(s): Barren homolog CAPH homolog |
Gene namesi | Name:BRN1 Ordered Locus Names:YBL097W ORF Names:YBL0830 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000193, BRN1 |
VEuPathDBi | FungiDB:YBL097W |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
- Chromosome 1 Publication
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Nucleus
- nuclear condensin complex Source: SGD
- nucleus Source: SGD
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095047 | 1 – 754 | Condensin complex subunit 2Add BLAST | 754 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 245 | PhosphoserineCombined sources | 1 | |
Modified residuei | 548 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P38170 |
PaxDbi | P38170 |
PRIDEi | P38170 |
PTM databases
CarbonylDBi | P38170 |
iPTMneti | P38170 |
Interactioni
Subunit structurei
Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.
1 PublicationBinary interactionsi
P38170
With | #Exp. | IntAct |
---|---|---|
SMC2 [P38989] | 2 | EBI-4792,EBI-17412 |
GO - Molecular functioni
- DNA topoisomerase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 32608, 444 interactors |
ComplexPortali | CPX-1869, Nuclear condensin complex |
DIPi | DIP-4662N |
IntActi | P38170, 11 interactors |
MINTi | P38170 |
STRINGi | 4932.YBL097W |
Miscellaneous databases
RNActi | P38170, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P38170 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the CND2 (condensin subunit 2) family.Curated
Phylogenomic databases
eggNOGi | KOG2328, Eukaryota |
GeneTreei | ENSGT00390000004149 |
HOGENOMi | CLU_010510_0_1_1 |
InParanoidi | P38170 |
OMAi | WIKMATD |
Family and domain databases
InterProi | View protein in InterPro IPR022816, Condensin_barren_su2 |
PANTHERi | PTHR13108, PTHR13108, 1 hit |
Pfami | View protein in Pfam PF05786, Cnd2, 2 hits |
PIRSFi | PIRSF017126, Condensin_H, 1 hit |
i Sequence
Sequence statusi: Complete.
P38170-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTQLRYENN DDDERVEYNL FTNRSTMMAN FEEWIKMATD NKINSRNSWN
60 70 80 90 100
FALIDYFYDL DVLKDGENNI NFQKASATLD GCIKIYSSRV DSVTTETGKL
110 120 130 140 150
LSGLAQRKTN GASNGDDSNG GNGEGLGGDS DEANIEIDPL TGMPISNDPD
160 170 180 190 200
VNNTRRRVYN RVLETTLVEF ETIKMKELDQ ELIIDPLFKK ALVDFDEGGA
210 220 230 240 250
KSLLLNTLNI DNTARVIFDA SIKDTQNVGQ GKLQRKEEEL IERDSLVDDE
260 270 280 290 300
NEPSQSLIST RNDSTVNDSV ISAPSMEDEI LSLGMDFIKF DQIAVCEISG
310 320 330 340 350
SIEQLRNVVE DINQAKDFIE NVNNRFDNFL TEEELQAAVP DNAEDDSDGF
360 370 380 390 400
DMGMQQELCY PDENHDNTSH DEQDDDNVNS TTGSIFEKDL MAYFDENLNR
410 420 430 440 450
NWRGREHWKV RNFKKANLVN KESDLLEETR TTIGDTTDKN TTDDKSMDTK
460 470 480 490 500
KKHKQKKVLE IDFFKTDDSF EDKVFASKGR TKIDMPIKNR KNDTHYLLPD
510 520 530 540 550
DFHFSTDRIT RLFIKPGQKM SLFSHRKHTR GDVSSGLFEK STVSANHSNN
560 570 580 590 600
DIPTIADEHF WADNYERKEQ EEKEKEQSKE VGDVVGGALD NPFEDDMDGV
610 620 630 640 650
DFNQAFEGTD DNEEASVKLD LQDDEDHKFP IRENKVTYSR VSKKVDVRRL
660 670 680 690 700
KKNVWRSINN LIQEHDSRKN REQSSNDSET HTEDESTKEL KFSDIIQGIS
710 720 730 740 750
KMYSDDTLKD ISTSFCFICL LHLANEHGLQ ITHTENYNDL IVNYEDLATT
QAAS
Sequence cautioni
The sequence CAA56003 differs from that shown. Reason: Frameshift.Curated
The sequence CAA84919 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 517 | G → A in CAA56003 (PubMed:7502586).Curated | 1 | |
Sequence conflicti | 517 | G → A in CAA84919 (PubMed:7813418).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79489 Genomic DNA Translation: CAA56003.1 Frameshift. Z35858 Genomic DNA Translation: CAA84919.1 Frameshift. AY558077 Genomic DNA Translation: AAS56403.1 BK006936 Genomic DNA Translation: DAA07028.2 |
PIRi | S45403 |
RefSeqi | NP_009455.3, NM_001178337.2 |
Genome annotation databases
EnsemblFungii | YBL097W_mRNA; YBL097W; YBL097W |
GeneIDi | 852180 |
KEGGi | sce:YBL097W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79489 Genomic DNA Translation: CAA56003.1 Frameshift. Z35858 Genomic DNA Translation: CAA84919.1 Frameshift. AY558077 Genomic DNA Translation: AAS56403.1 BK006936 Genomic DNA Translation: DAA07028.2 |
PIRi | S45403 |
RefSeqi | NP_009455.3, NM_001178337.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5OQN | X-ray | 3.15 | B | 384-529 | [»] | |
5OQO | X-ray | 3.25 | B | 384-529 | [»] | |
5OQP | X-ray | 2.98 | B | 384-529 | [»] | |
5OQQ | X-ray | 2.79 | C/D | 384-529 | [»] | |
6YVD | electron microscopy | 7.60 | B | 1-754 | [»] | |
6YVU | electron microscopy | 7.50 | C | 1-754 | [»] | |
6YVV | electron microscopy | 7.50 | C | 1-754 | [»] | |
SMRi | P38170 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32608, 444 interactors |
ComplexPortali | CPX-1869, Nuclear condensin complex |
DIPi | DIP-4662N |
IntActi | P38170, 11 interactors |
MINTi | P38170 |
STRINGi | 4932.YBL097W |
PTM databases
CarbonylDBi | P38170 |
iPTMneti | P38170 |
Proteomic databases
MaxQBi | P38170 |
PaxDbi | P38170 |
PRIDEi | P38170 |
Genome annotation databases
EnsemblFungii | YBL097W_mRNA; YBL097W; YBL097W |
GeneIDi | 852180 |
KEGGi | sce:YBL097W |
Organism-specific databases
SGDi | S000000193, BRN1 |
VEuPathDBi | FungiDB:YBL097W |
Phylogenomic databases
eggNOGi | KOG2328, Eukaryota |
GeneTreei | ENSGT00390000004149 |
HOGENOMi | CLU_010510_0_1_1 |
InParanoidi | P38170 |
OMAi | WIKMATD |
Enzyme and pathway databases
Reactomei | R-SCE-2514853, Condensation of Prometaphase Chromosomes |
Miscellaneous databases
PROi | PR:P38170 |
RNActi | P38170, protein |
Family and domain databases
InterProi | View protein in InterPro IPR022816, Condensin_barren_su2 |
PANTHERi | PTHR13108, PTHR13108, 1 hit |
Pfami | View protein in Pfam PF05786, Cnd2, 2 hits |
PIRSFi | PIRSF017126, Condensin_H, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CND2_YEAST | |
Accessioni | P38170Primary (citable) accession number: P38170 Secondary accession number(s): D6VPQ8, Q6Q5G8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 164 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families