RBMX

Functionⁱ

RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.7 Publications

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18541147
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10749975
mRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12165565
- 12761049
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10749975
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21327109
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18541147
single-stranded RNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to interleukin-1
Source: UniProtKB
Inferred from direct assayⁱ
- 18445477
membrane protein ectodomain proteolysis
Source: UniProtKB
Inferred from direct assayⁱ
- 18445477
mRNA splice site selection Source: Ensembl
mRNA splicing, via spliceosome Source: Reactome
negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
osteoblast differentiation
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 16210410
positive regulation of mRNA splicing, via spliceosome Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 18541147
protein complex oligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 10749975
protein homooligomerization Source: UniProtKB
regulation of alternative mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 12165565
- 12761049
RNA metabolic process Source: Reactome
transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 21327109

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Repressor, Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA splicing, Transcription

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-binding motif protein, X chromosome Alternative name(s): Glycoprotein p43 Heterogeneous nuclear ribonucleoprotein G Short name: hnRNP G Cleaved into the following chain: RNA-binding motif protein, X chromosome, N-terminally processed
Gene namesⁱ	Name:RBMX Synonyms:HNRPG, RBMXP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147274.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9910 RBMX
MIMⁱ	300199 gene
neXtProtⁱ	NX_P38159

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mental retardation, X-linked, syndromic, 11 (MRXS11)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXS11 patients manifest moderate intellectual disability and craniofacial dysmorphism.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	22	K → A: Promotes cell proliferation. Inhibits transcriptional up-regulation of the TXNIP promoter. 2 Publications		1

Keywords - Diseaseⁱ

Mental retardation, Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27316
MalaCards human disease database More...MalaCardsⁱ	RBMX
MIMⁱ	300238 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000147274
PharmGKBⁱ	PA34277

Polymorphism and mutation databases

BioMutaⁱ	RBMX
DMDMⁱ	23503093

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000081854	1 – 391	RNA-binding motif protein, X chromosomeAdd BLAST	391
Initiator methionineⁱ		Removed; alternate1 Publication
ChainⁱPRO_0000304582	2 – 391	RNA-binding motif protein, X chromosome, N-terminally processedAdd BLAST	390

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein G; alternate1 Publication	1
Modified residueⁱ	2	N-acetylvaline; in Heterogeneous nuclear ribonucleoprotein G, N-terminally processed1 Publication	1
Cross-linkⁱ	22	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	30	N6-acetyllysineCombined sources	1
Cross-linkⁱ	80	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	86	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	88	PhosphoserineCombined sources	1
Modified residueⁱ	91	PhosphoserineCombined sources	1
Modified residueⁱ	125	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	144	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	164	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	172	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	174	PhosphoserineCombined sources	1
Modified residueⁱ	261	PhosphoserineCombined sources	1
Modified residueⁱ	328	PhosphoserineCombined sources	1
Modified residueⁱ	329	PhosphoserineCombined sources	1
Modified residueⁱ	330	PhosphoserineCombined sources	1
Modified residueⁱ	332	PhosphoserineCombined sources	1
Modified residueⁱ	352	PhosphoserineCombined sources	1

Post-translational modificationⁱ

O-glycosylated.1 Publication

Arg-185 is dimethylated, probably to asymmetric dimethylarginine.

Cleavage of initiator Met is partial. If Met-1 is not removed, it is acetylated. If it is removed, Val-2 is acetylated.1 Publication

Keywords - PTMⁱ

Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P38159
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P38159
PaxDbⁱ	P38159
PeptideAtlas More...PeptideAtlasⁱ	P38159
PRIDEⁱ	P38159
ProteomicsDBⁱ	55284 55285 [P38159-2] 55286 [P38159-3]
TopDownProteomicsⁱ	P38159-1 [P38159-1]

2D gel databases

SWISS-2DPAGEⁱ	P38159

SWISS-2DPAGEⁱ

P38159

PTM databases

iPTMnetⁱ	P38159
PhosphoSitePlusⁱ	P38159
SwissPalmⁱ	P38159

Expressionⁱ

Tissue specificityⁱ

Expressed strongly in oral keratinocytes, but only weakly detected in oral squamous cell carcinomas (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000147274 Expressed in 204 organ(s), highest expression level in kidney
CleanExⁱ	HS_RBMX
ExpressionAtlasⁱ	P38159 baseline and differential
Genevisibleⁱ	P38159 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA057707

HPAⁱ

HPA057707

Interactionⁱ

Subunit structureⁱ

Homomultimer. Interacts with SAFB/SAFB1 (By similarity). Found in the supraspliceosome complex. Identified in the spliceosome C complex. Interacts with KHDRBS3. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA. Interacts with CLK2, KHDRBS2, SAFB, TRA2B and YTHDC1. Interacts with ERAP1; the interaction is RNA-independent.By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		5	EBI-743526,EBI-743526
APOBEC3C	Q9NRW3	5	EBI-743526,EBI-1044593
CIRBP	Q14011	4	EBI-743526,EBI-538850
CLK3	P49761	3	EBI-743526,EBI-745579
HNRNPK	P61978	11	EBI-743526,EBI-304185
HNRNPK	P61978-2	4	EBI-743526,EBI-7060731
KHDRBS2	Q5VWX1	11	EBI-743526,EBI-742808
KHDRBS3	O75525	3	EBI-743526,EBI-722504
LNX1	Q8TBB1	3	EBI-743526,EBI-739832
MAGOHB	Q96A72	3	EBI-743526,EBI-746778
NABP1	Q96AH0	5	EBI-743526,EBI-2889252
PRPF31	Q8WWY3	5	EBI-743526,EBI-1567797
PRR3	P79522	5	EBI-743526,EBI-2803328
RBM3	P98179	5	EBI-743526,EBI-2949699
RBMY1A1	P0DJD3	3	EBI-743526,EBI-8638511
RBMY1A1	P0DJD3-2	4	EBI-743526,EBI-11994018
RBMY1J	Q15415	7	EBI-743526,EBI-8642021
ROBO3	Q96HH0	3	EBI-743526,EBI-10288358
SNRPA	P09012	3	EBI-743526,EBI-607085
Srek1	Q9JKL7	3	EBI-743526,EBI-6452221	From Rattus norvegicus.
TRA2B	P62995	3	EBI-743526,EBI-725485

GO - Molecular functionⁱ

identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10749975
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10749975

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118134, 168 interactors
CORUMⁱ	P38159
Database of interacting proteins More...DIPⁱ	DIP-34447N
IntActⁱ	P38159, 97 interactors
Molecular INTeraction database More...MINTⁱ	P38159
STRINGⁱ	9606.ENSP00000359645

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	9 – 13	Combined sources	5
Helixⁱ	21 – 28	Combined sources	8
Turnⁱ	29 – 31	Combined sources	3
Beta strandⁱ	34 – 39	Combined sources	6
Turnⁱ	43 – 45	Combined sources	3
Beta strandⁱ	50 – 58	Combined sources	9
Helixⁱ	61 – 66	Combined sources	6
Beta strandⁱ	67 – 74	Combined sources	8
Beta strandⁱ	80 – 83	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P38159
SMRⁱ	P38159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 86	RRMPROSITE-ProRule annotationAdd BLAST		79

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	186 – 236	Necessary for the association to nascent RNAPII transcripts and nuclear localizationAdd BLAST		51
Regionⁱ	333 – 391	Necessary for RNA-bindingAdd BLAST		59

Domainⁱ

The RRM domain is necessary for RNA-binding, but not for splice site selection, indicating that its splicing activity does not require direct binding to RNA.By similarity

Phylogenomic databases

eggNOGⁱ	ENOG410IHG3 Eukaryota ENOG4111GI6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00710000106295
HOGENOMⁱ	HOG000276235
HOVERGENⁱ	HBG063314
InParanoidⁱ	P38159
KEGG Orthology (KO) More...KOⁱ	K12885
OMAⁱ	DPGACFK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13K0
PhylomeDBⁱ	P38159
TreeFamⁱ	TF331833

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR012604 RBM1CTR IPR000504 RRM_dom IPR003954 RRM_dom_euk
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08081 RBM1CTR, 1 hit PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00361 RRM_1, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P38159-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRETNKSRG 
        60         70         80         90        100
FAFVTFESPA DAKDAARDMN GKSLDGKAIK VEQATKPSFE SGRRGPPPPP 
       110        120        130        140        150
RSRGPPRGLR GGRGGSGGTR GPPSRGGHMD DGGYSMNFNM SSSRGPLPVK 
       160        170        180        190        200
RGPPPRSGGP PPKRSAPSGP VRSSSGMGGR APVSRGRDSY GGPPRREPLP 
       210        220        230        240        250
SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD YTYRDYGHSS 
       260        270        280        290        300
SRDDYPSRGY SDRDGYGRDR DYSDHPSGGS YRDSYESYGN SRSAPPTRGP 
       310        320        330        340        350
PPSYGGSSRY DDYSSSRDGY GGSRDSYSSS RSDLYSSGRD RVGRQERGLP 
       360        370        380        390 
PSMERGYPPP RDSYSSSSRG APRGGGRGGS RSDRGGGRSR Y

Length:391

Mass (Da):42,332

Last modified:September 19, 2002 - v3

Checksum:ⁱ904FEB9BFC573546

GO

Isoform 2 (identifier: P38159-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
45-57: Missing.

« Hide

        10         20         30         40         50
MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRESPADAK 
        60         70         80         90        100
DAARDMNGKS LDGKAIKVEQ ATKPSFESGR RGPPPPPRSR GPPRGLRGGR 
       110        120        130        140        150
GGSGGTRGPP SRGGHMDDGG YSMNFNMSSS RGPLPVKRGP PPRSGGPPPK 
       160        170        180        190        200
RSAPSGPVRS SSGMGGRAPV SRGRDSYGGP PRREPLPSRR DVYLSPRDDG 
       210        220        230        240        250
YSTKDSYSSR DYPSSRDTRD YAPPPRDYTY RDYGHSSSRD DYPSRGYSDR 
       260        270        280        290        300
DGYGRDRDYS DHPSGGSYRD SYESYGNSRS APPTRGPPPS YGGSSRYDDY 
       310        320        330        340        350
SSSRDGYGGS RDSYSSSRSD LYSSGRDRVG RQERGLPPSM ERGYPPPRDS 
       360        370 
YSSSSRGAPR GGGRGGSRSD RGGGRSRY

Show »

Length:378

Mass (Da):40,846

Checksum:ⁱ032DD488FA08CE19

GO

Isoform 3 (identifier: P38159-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
73-196: SLDGKAIKVE...RDSYGGPPRR → LLYHVEEIVM...YGRGVLIDSQ
197-391: Missing.

« Hide

        10         20         30         40         50
MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRETNKSRG 
        60         70         80         90        100
FAFVTFESPA DAKDAARDMN GKLLYHVEEI VMEVHLEGNR CPLVEMFICP 
       110        120        130        140        150
QEMMGILLKT AIQAEITQVL VILEIMHHHH EIILTVIMVI PVHVMTIHQE 
       160        170        180        190 
DIAIEMDMVV IVTIQIIQVE VPTEIHMRVM VGDFAHYGRG VLIDSQ

Note: No experimental confirmation available.

Show »

Length:196

Mass (Da):22,172

Checksum:ⁱ7FB2ABEE20A3D582

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y6E7	H0Y6E7_HUMAN	RNA-binding motif protein, X chromo... RNA-binding motif protein, X chromosome	RBMX	292	Annotation score:
H3BT71	H3BT71_HUMAN	RNA-binding motif protein, X chromo... RNA-binding motif protein, X chromosome	RBMX	296	Annotation score:
H3BNC1	H3BNC1_HUMAN	RNA-binding motif protein, X chromo... RNA-binding motif protein, X chromosome	RBMX	37	Annotation score:
H3BR27	H3BR27_HUMAN	RNA-binding motif protein, X chromo... RNA-binding motif protein, X chromosome	RBMX	78	Annotation score:
H3BUY5	H3BUY5_HUMAN	RNA-binding motif protein, X chromo... RNA-binding motif protein, X chromosome	RBMX	263	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	259	G → E in CAA80599 (PubMed:7692398).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_042203	45 – 57	Missing in isoform 2. 1 PublicationAdd BLAST	13
Alternative sequenceⁱVSP_043650	73 – 196	SLDGK…GPPRR → LLYHVEEIVMEVHLEGNRCP LVEMFICPQEMMGILLKTAI QAEITQVLVILEIMHHHHEI ILTVIMVIPVHVMTIHQEDI AIEMDMVVIVTIQIIQVEVP TEIHMRVMVGDFAHYGRGVL IDSQ in isoform 3. 1 PublicationAdd BLAST	124
Alternative sequenceⁱVSP_043651	197 – 391	Missing in isoform 3. 1 PublicationAdd BLAST	195

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z23064 mRNA Translation: CAA80599.1 AF266723 , AF266720, AF266721, AF266722 Genomic DNA Translation: AAK58567.1 AY464692 mRNA Translation: AAR28036.1 AK096015 mRNA Translation: BAC04674.1 AK304868 mRNA Translation: BAG65606.1 AL683813 Genomic DNA No translation available. CH471150 Genomic DNA Translation: EAW88453.1 CH471150 Genomic DNA Translation: EAW88454.1 CH471150 Genomic DNA Translation: EAW88455.1 CH471150 Genomic DNA Translation: EAW88457.1 BC006550 mRNA Translation: AAH06550.1 BC007435 mRNA Translation: AAH07435.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14661.1 [P38159-1] CCDS55510.1 [P38159-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001158275.1, NM_001164803.1 [P38159-3] NP_002130.2, NM_002139.3 [P38159-1]
UniGeneⁱ	Hs.380118 Hs.710162

Genome annotation databases

Ensemblⁱ	ENST00000320676; ENSP00000359645; ENSG00000147274 [P38159-1] ENST00000431446; ENSP00000411989; ENSG00000147274 [P38159-3]
GeneIDⁱ	27316
KEGGⁱ	hsa:27316
UCSC genome browser More...UCSCⁱ	uc004fae.4 human [P38159-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P38159	RNA-binding motif protein, X chromosome		PANTR		391	UniRef100_P38159
RNA binding motif protein X-linked		FELCA		487
RNA binding motif protein, X-linked (Fragment)		MUSPF		392
Uncharacterized protein		CANLF		392
RBMX		CALJA		391
+33

Protein	Similar proteins		Species	Score	Length	Source
P38159	RNA-binding motif protein, X chromosome		PANTR		391	UniRef90_P38159
RNA-binding motif protein, X chromosome		MOUSE		391
RNA-binding motif protein, X chromosome		MACFA		391
RNA binding motif protein, X-linked-like-1		HUMAN		390
RNA-binding motif protein, X chromosome		RAT		390
+177
P38159-2	RNA binding motif protein, X-linked-like-1		MOUSE		388	UniRef90_P38159-2
RNA-binding motif protein, X chromosome isoform X1		AMAAE		425
RNA-binding motif protein, X chromosome isoform B		ALLMI		421
RNA-binding motif protein, X chromosome isoform X1		ALLSI		386
Uncharacterized protein		PELSI		386
+116
P38159-3	Uncharacterized protein		PANPA		197	UniRef90_P38159-3
RBMX isoform 5		PANTR		196
Uncharacterized protein		MACMU		196
Uncharacterized protein		COLAP		196
Uncharacterized protein		PAPAN		196
+10

Protein	Similar proteins		Species	Score	Length	Source
P38159	RNA-binding motif protein, X chromosome		PANTR		391	UniRef50_P38159
RNA-binding motif protein, X chromosome		MACFA		391
RNA-binding motif protein, X chromosome		MOUSE		391
RNA-binding motif protein, X chromosome		RAT		390
RNA binding motif protein, X-linked-like-1		HUMAN		390
+356
P38159-3	Uncharacterized protein		PANPA		197	UniRef50_P38159-3
RBMX isoform 2		PONAB		196
Uncharacterized protein		GORGO		196
Uncharacterized protein		MACMU		196
Uncharacterized protein		COLAP		196
+28

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z23064 mRNA Translation: CAA80599.1 AF266723 , AF266720, AF266721, AF266722 Genomic DNA Translation: AAK58567.1 AY464692 mRNA Translation: AAR28036.1 AK096015 mRNA Translation: BAC04674.1 AK304868 mRNA Translation: BAG65606.1 AL683813 Genomic DNA No translation available. CH471150 Genomic DNA Translation: EAW88453.1 CH471150 Genomic DNA Translation: EAW88454.1 CH471150 Genomic DNA Translation: EAW88455.1 CH471150 Genomic DNA Translation: EAW88457.1 BC006550 mRNA Translation: AAH06550.1 BC007435 mRNA Translation: AAH07435.1
CCDSⁱ	CCDS14661.1 [P38159-1] CCDS55510.1 [P38159-3]
RefSeqⁱ	NP_001158275.1, NM_001164803.1 [P38159-3] NP_002130.2, NM_002139.3 [P38159-1]
UniGeneⁱ	Hs.380118 Hs.710162

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MB0	NMR	-	B	1-95	[»]
	2MKS	NMR	-	A	1-90	[»]
ProteinModelPortalⁱ	P38159
SMRⁱ	P38159
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118134, 168 interactors
CORUMⁱ	P38159
DIPⁱ	DIP-34447N
IntActⁱ	P38159, 97 interactors
MINTⁱ	P38159
STRINGⁱ	9606.ENSP00000359645

PTM databases

iPTMnetⁱ	P38159
PhosphoSitePlusⁱ	P38159
SwissPalmⁱ	P38159

Polymorphism and mutation databases

BioMutaⁱ	RBMX
DMDMⁱ	23503093

2D gel databases

SWISS-2DPAGEⁱ	P38159

SWISS-2DPAGEⁱ

P38159

Proteomic databases

EPDⁱ	P38159
MaxQBⁱ	P38159
PaxDbⁱ	P38159
PeptideAtlasⁱ	P38159
PRIDEⁱ	P38159
ProteomicsDBⁱ	55284 55285 [P38159-2] 55286 [P38159-3]
TopDownProteomicsⁱ	P38159-1 [P38159-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	27316
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000320676; ENSP00000359645; ENSG00000147274 [P38159-1] ENST00000431446; ENSP00000411989; ENSG00000147274 [P38159-3]
GeneIDⁱ	27316
KEGGⁱ	hsa:27316
UCSCⁱ	uc004fae.4 human [P38159-1]

Organism-specific databases

CTDⁱ	27316
DisGeNETⁱ	27316
EuPathDBⁱ	HostDB:ENSG00000147274.14
GeneCardsⁱ	RBMX
HGNCⁱ	HGNC:9910 RBMX
HPAⁱ	HPA057707
MalaCardsⁱ	RBMX
MIMⁱ	300199 gene 300238 phenotype
neXtProtⁱ	NX_P38159
OpenTargetsⁱ	ENSG00000147274
PharmGKBⁱ	PA34277
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHG3 Eukaryota ENOG4111GI6 LUCA
GeneTreeⁱ	ENSGT00710000106295
HOGENOMⁱ	HOG000276235
HOVERGENⁱ	HBG063314
InParanoidⁱ	P38159
KOⁱ	K12885
OMAⁱ	DPGACFK
OrthoDBⁱ	EOG091G13K0
PhylomeDBⁱ	P38159
TreeFamⁱ	TF331833

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRSⁱ	RBMX human
GeneWikiⁱ	RBMX
GenomeRNAiⁱ	27316
Protein Ontology More...PROⁱ	PR:P38159
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147274 Expressed in 204 organ(s), highest expression level in kidney
CleanExⁱ	HS_RBMX
ExpressionAtlasⁱ	P38159 baseline and differential
Genevisibleⁱ	P38159 HS

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR012604 RBM1CTR IPR000504 RRM_dom IPR003954 RRM_dom_euk
Pfamⁱ	View protein in Pfam PF08081 RBM1CTR, 1 hit PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00361 RRM_1, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RBMX_HUMAN
Accessionⁱ	P38159Primary (citable) accession number: P38159 Secondary accession number(s): B4E3U4 , D3DWH0, E9PG86, Q5JQ67, Q8N8Y7, Q969R3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	September 19, 2002
	Last modified:	November 7, 2018
	This is version 206 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P38159 (RBMX_HUMAN)

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RNA-binding motif protein, X chromosome

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Organism-specific databases

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Keywords - PTMi

Proteomic databases

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Gene expression databases

Organism-specific databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ