UniProtKB - P38159 (RBMX_HUMAN)
RNA-binding motif protein, X chromosome
RBMX
Functioni
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- mRNA binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- cellular response to interleukin-1 Source: UniProtKB
- membrane protein ectodomain proteolysis Source: UniProtKB
- mRNA splicing, via spliceosome Source: Reactome
- negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
- osteoblast differentiation Source: UniProtKB
- positive regulation of mRNA splicing, via spliceosome Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein homooligomerization Source: UniProtKB
- regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
- RNA metabolic process Source: Reactome
- transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | Activator, Repressor, Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing, Transcription |
Enzyme and pathway databases
PathwayCommonsi | P38159 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding motif protein, X chromosomeAlternative name(s): Glycoprotein p43 Heterogeneous nuclear ribonucleoprotein G Short name: hnRNP G Cleaved into the following chain: |
Gene namesi | Name:RBMX Synonyms:HNRPG, RBMXP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000147274.14 |
HGNCi | HGNC:9910, RBMX |
MIMi | 300199, gene |
neXtProti | NX_P38159 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Note: Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nuclear euchromatin Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- spliceosomal complex Source: GO_Central
- supraspliceosomal complex Source: UniProtKB
Other locations
- membrane Source: UniProtKB
- protein-containing complex Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Involvement in diseasei
Mental retardation, X-linked, syndromic, 11 (MRXS11)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 22 | K → A: Promotes cell proliferation. Inhibits transcriptional up-regulation of the TXNIP promoter. 2 Publications | 1 |
Keywords - Diseasei
Mental retardation, Tumor suppressorOrganism-specific databases
DisGeNETi | 27316 |
MalaCardsi | RBMX |
MIMi | 300238, phenotype |
OpenTargetsi | ENSG00000147274 |
PharmGKBi | PA34277 |
Miscellaneous databases
Pharosi | P38159, Tbio |
Polymorphism and mutation databases
BioMutai | RBMX |
DMDMi | 23503093 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081854 | 1 – 391 | RNA-binding motif protein, X chromosomeAdd BLAST | 391 | |
Initiator methioninei | Removed; alternate1 Publication | |||
ChainiPRO_0000304582 | 2 – 391 | RNA-binding motif protein, X chromosome, N-terminally processedAdd BLAST | 390 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein G; alternate1 Publication | 1 | |
Modified residuei | 2 | N-acetylvaline; in Heterogeneous nuclear ribonucleoprotein G, N-terminally processed1 Publication | 1 | |
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 30 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 80 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 86 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 88 | PhosphoserineCombined sources | 1 | |
Modified residuei | 91 | PhosphoserineCombined sources | 1 | |
Modified residuei | 125 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 144 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 164 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 172 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 174 | PhosphoserineCombined sources | 1 | |
Modified residuei | 261 | PhosphoserineCombined sources | 1 | |
Modified residuei | 328 | PhosphoserineCombined sources | 1 | |
Modified residuei | 329 | PhosphoserineCombined sources | 1 | |
Modified residuei | 330 | PhosphoserineCombined sources | 1 | |
Modified residuei | 332 | PhosphoserineCombined sources | 1 | |
Modified residuei | 352 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P38159 |
jPOSTi | P38159 |
MassIVEi | P38159 |
MaxQBi | P38159 |
PaxDbi | P38159 |
PeptideAtlasi | P38159 |
PRIDEi | P38159 |
ProteomicsDBi | 55284 [P38159-1] 55285 [P38159-2] 55286 [P38159-3] |
TopDownProteomicsi | P38159-1 [P38159-1] |
2D gel databases
SWISS-2DPAGEi | P38159 |
PTM databases
iPTMneti | P38159 |
PhosphoSitePlusi | P38159 |
SwissPalmi | P38159 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000147274, Expressed in ventricular zone and 217 other tissues |
ExpressionAtlasi | P38159, baseline and differential |
Genevisiblei | P38159, HS |
Organism-specific databases
HPAi | ENSG00000147274, Low tissue specificity |
Interactioni
Subunit structurei
Homomultimer.
Interacts with SAFB/SAFB1 (By similarity).
Found in the supraspliceosome complex. Identified in the spliceosome C complex.
Interacts with KHDRBS3.
Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, NCOA5 and PPP1CA.
Interacts with CLK2, KHDRBS2, SAFB, TRA2B and YTHDC1.
Interacts with ERAP1; the interaction is RNA-independent (PubMed:18445477).
Interacts with PPIA/CYPA (PubMed:25678563).
By similarity7 PublicationsBinary interactionsi
Hide detailsP38159
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 118134, 218 interactors |
CORUMi | P38159 |
DIPi | DIP-34447N |
IntActi | P38159, 132 interactors |
MINTi | P38159 |
STRINGi | 9606.ENSP00000359645 |
Miscellaneous databases
RNActi | P38159, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P38159 |
SMRi | P38159 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 86 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 186 – 236 | Necessary for the association to nascent RNAPII transcripts and nuclear localizationAdd BLAST | 51 | |
Regioni | 333 – 391 | Necessary for RNA-bindingAdd BLAST | 59 |
Domaini
Phylogenomic databases
eggNOGi | ENOG502QS9N, Eukaryota |
GeneTreei | ENSGT00940000153425 |
HOGENOMi | CLU_1395869_0_0_1 |
InParanoidi | P38159 |
OMAi | AKYHEGF |
OrthoDBi | 1248417at2759 |
PhylomeDBi | P38159 |
TreeFami | TF331833 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR012604, RBM1CTR IPR000504, RRM_dom IPR003954, RRM_dom_euk |
Pfami | View protein in Pfam PF08081, RBM1CTR, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00361, RRM_1, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRETNKSRG
60 70 80 90 100
FAFVTFESPA DAKDAARDMN GKSLDGKAIK VEQATKPSFE SGRRGPPPPP
110 120 130 140 150
RSRGPPRGLR GGRGGSGGTR GPPSRGGHMD DGGYSMNFNM SSSRGPLPVK
160 170 180 190 200
RGPPPRSGGP PPKRSAPSGP VRSSSGMGGR APVSRGRDSY GGPPRREPLP
210 220 230 240 250
SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD YTYRDYGHSS
260 270 280 290 300
SRDDYPSRGY SDRDGYGRDR DYSDHPSGGS YRDSYESYGN SRSAPPTRGP
310 320 330 340 350
PPSYGGSSRY DDYSSSRDGY GGSRDSYSSS RSDLYSSGRD RVGRQERGLP
360 370 380 390
PSMERGYPPP RDSYSSSSRG APRGGGRGGS RSDRGGGRSR Y
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y6E7 | H0Y6E7_HUMAN | RNA-binding motif protein, X chromo... | RBMX | 292 | Annotation score: | ||
H3BT71 | H3BT71_HUMAN | RNA-binding motif protein, X chromo... | RBMX | 296 | Annotation score: | ||
H3BUY5 | H3BUY5_HUMAN | RNA-binding motif protein, X chromo... | RBMX | 263 | Annotation score: | ||
H3BNC1 | H3BNC1_HUMAN | RNA-binding motif protein, X chromo... | RBMX | 37 | Annotation score: | ||
H3BR27 | H3BR27_HUMAN | RNA-binding motif protein, X chromo... | RBMX | 78 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 259 | G → E in CAA80599 (PubMed:7692398).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042203 | 45 – 57 | Missing in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_043650 | 73 – 196 | SLDGK…GPPRR → LLYHVEEIVMEVHLEGNRCP LVEMFICPQEMMGILLKTAI QAEITQVLVILEIMHHHHEI ILTVIMVIPVHVMTIHQEDI AIEMDMVVIVTIQIIQVEVP TEIHMRVMVGDFAHYGRGVL IDSQ in isoform 3. 1 PublicationAdd BLAST | 124 | |
Alternative sequenceiVSP_043651 | 197 – 391 | Missing in isoform 3. 1 PublicationAdd BLAST | 195 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23064 mRNA Translation: CAA80599.1 AF266723 , AF266720, AF266721, AF266722 Genomic DNA Translation: AAK58567.1 AY464692 mRNA Translation: AAR28036.1 AK096015 mRNA Translation: BAC04674.1 AK304868 mRNA Translation: BAG65606.1 AL683813 Genomic DNA No translation available. CH471150 Genomic DNA Translation: EAW88453.1 CH471150 Genomic DNA Translation: EAW88454.1 CH471150 Genomic DNA Translation: EAW88455.1 CH471150 Genomic DNA Translation: EAW88457.1 BC006550 mRNA Translation: AAH06550.1 BC007435 mRNA Translation: AAH07435.1 |
CCDSi | CCDS14661.1 [P38159-1] CCDS55510.1 [P38159-3] |
RefSeqi | NP_001158275.1, NM_001164803.1 [P38159-3] NP_002130.2, NM_002139.3 [P38159-1] |
Genome annotation databases
Ensembli | ENST00000320676; ENSP00000359645; ENSG00000147274 [P38159-1] ENST00000431446; ENSP00000411989; ENSG00000147274 [P38159-3] |
GeneIDi | 27316 |
KEGGi | hsa:27316 |
UCSCi | uc004fae.4, human [P38159-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23064 mRNA Translation: CAA80599.1 AF266723 , AF266720, AF266721, AF266722 Genomic DNA Translation: AAK58567.1 AY464692 mRNA Translation: AAR28036.1 AK096015 mRNA Translation: BAC04674.1 AK304868 mRNA Translation: BAG65606.1 AL683813 Genomic DNA No translation available. CH471150 Genomic DNA Translation: EAW88453.1 CH471150 Genomic DNA Translation: EAW88454.1 CH471150 Genomic DNA Translation: EAW88455.1 CH471150 Genomic DNA Translation: EAW88457.1 BC006550 mRNA Translation: AAH06550.1 BC007435 mRNA Translation: AAH07435.1 |
CCDSi | CCDS14661.1 [P38159-1] CCDS55510.1 [P38159-3] |
RefSeqi | NP_001158275.1, NM_001164803.1 [P38159-3] NP_002130.2, NM_002139.3 [P38159-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MB0 | NMR | - | B | 1-95 | [»] | |
2MKS | NMR | - | A | 1-90 | [»] | |
BMRBi | P38159 | |||||
SMRi | P38159 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118134, 218 interactors |
CORUMi | P38159 |
DIPi | DIP-34447N |
IntActi | P38159, 132 interactors |
MINTi | P38159 |
STRINGi | 9606.ENSP00000359645 |
PTM databases
iPTMneti | P38159 |
PhosphoSitePlusi | P38159 |
SwissPalmi | P38159 |
Polymorphism and mutation databases
BioMutai | RBMX |
DMDMi | 23503093 |
2D gel databases
SWISS-2DPAGEi | P38159 |
Proteomic databases
EPDi | P38159 |
jPOSTi | P38159 |
MassIVEi | P38159 |
MaxQBi | P38159 |
PaxDbi | P38159 |
PeptideAtlasi | P38159 |
PRIDEi | P38159 |
ProteomicsDBi | 55284 [P38159-1] 55285 [P38159-2] 55286 [P38159-3] |
TopDownProteomicsi | P38159-1 [P38159-1] |
Protocols and materials databases
ABCDi | P38159, 1 sequenced antibody |
Antibodypediai | 30459, 152 antibodies |
DNASUi | 27316 |
Genome annotation databases
Ensembli | ENST00000320676; ENSP00000359645; ENSG00000147274 [P38159-1] ENST00000431446; ENSP00000411989; ENSG00000147274 [P38159-3] |
GeneIDi | 27316 |
KEGGi | hsa:27316 |
UCSCi | uc004fae.4, human [P38159-1] |
Organism-specific databases
CTDi | 27316 |
DisGeNETi | 27316 |
EuPathDBi | HostDB:ENSG00000147274.14 |
GeneCardsi | RBMX |
HGNCi | HGNC:9910, RBMX |
HPAi | ENSG00000147274, Low tissue specificity |
MalaCardsi | RBMX |
MIMi | 300199, gene 300238, phenotype |
neXtProti | NX_P38159 |
OpenTargetsi | ENSG00000147274 |
PharmGKBi | PA34277 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS9N, Eukaryota |
GeneTreei | ENSGT00940000153425 |
HOGENOMi | CLU_1395869_0_0_1 |
InParanoidi | P38159 |
OMAi | AKYHEGF |
OrthoDBi | 1248417at2759 |
PhylomeDBi | P38159 |
TreeFami | TF331833 |
Enzyme and pathway databases
PathwayCommonsi | P38159 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
Miscellaneous databases
BioGRID-ORCSi | 27316, 392 hits in 479 CRISPR screens |
ChiTaRSi | RBMX, human |
GeneWikii | RBMX |
GenomeRNAii | 27316 |
Pharosi | P38159, Tbio |
PROi | PR:P38159 |
RNActi | P38159, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147274, Expressed in ventricular zone and 217 other tissues |
ExpressionAtlasi | P38159, baseline and differential |
Genevisiblei | P38159, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR012604, RBM1CTR IPR000504, RRM_dom IPR003954, RRM_dom_euk |
Pfami | View protein in Pfam PF08081, RBM1CTR, 1 hit PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00361, RRM_1, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBMX_HUMAN | |
Accessioni | P38159Primary (citable) accession number: P38159 Secondary accession number(s): B4E3U4 Q969R3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | September 19, 2002 | |
Last modified: | December 2, 2020 | |
This is version 223 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM