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Protein

Alpha-glucosidase MAL32

Gene

MAL32

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 4030 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214NucleophileBy similarity1
Active sitei276Proton donorBy similarity1
Sitei349Transition state stabilizerBy similarity1

GO - Molecular functioni

  • alpha-1,4-glucosidase activity Source: SGD
  • glucan 1,4-alpha-maltotriohydrolase activity Source: SGD
  • maltose alpha-glucosidase activity Source: SGD
  • sucrose alpha-glucosidase activity Source: SGD

GO - Biological processi

  • maltose catabolic process Source: SGD
  • sucrose catabolic process Source: SGD

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processMaltose metabolism

Enzyme and pathway databases

BioCyciYEAST:YBR299W-MONOMER

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase MAL32 (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:MAL32
Synonyms:MAL3S
Ordered Locus Names:YBR299W
ORF Names:YBR2117
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR299W
SGDiS000000503 MAL32

Pathology & Biotechi

Protein family/group databases

Allergomei8262 Sac c Glucosidase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000543291 – 584Alpha-glucosidase MAL32Add BLAST584

Proteomic databases

MaxQBiP38158
PaxDbiP38158
PRIDEiP38158
TopDownProteomicsiP38158

Interactioni

Protein-protein interaction databases

BioGridi32992, 57 interactors
DIPiDIP-6822N
IntActiP38158, 8 interactors
STRINGi4932.YBR299W

Chemistry databases

BindingDBiP38158

Structurei

3D structure databases

ProteinModelPortaliP38158
SMRiP38158
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38158

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Phylogenomic databases

GeneTreeiENSGT00900000140965
HOGENOMiHOG000220641
InParanoidiP38158
KOiK01182
OMAiFHYADID
OrthoDBiEOG092C12JX

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006047 Glyco_hydro_13_cat_dom
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00128 Alpha-amylase, 1 hit
SMARTiView protein in SMART
SM00642 Aamy, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

P38158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISDHPETE PKWWKEATIY QIYPASFKDS NNDGWGDLKG ITSKLQYIKD
60 70 80 90 100
LGVDAIWVCP FYDSPQQDMG YDISNYEKVW PTYGTNEDCF ELIDKTHKLG
110 120 130 140 150
MKFITDLVIN HCSTEHEWFK ESRSSKTNPK RDWFFWRPPK GYDAEGKPIP
160 170 180 190 200
PNNWKSFFGG SAWTFDETTN EFYLRLFASR QVDLNWENED CRRAIFESAV
210 220 230 240 250
GFWLDHGVDG FRIDTAGLYS KRPGLPDSPI FDKTSKLQHP NWGSHNGPRI
260 270 280 290 300
HEYHQELHRF MKNRVKDGRE IMTVGEVAHG SDNALYTSAA RYEVSEVFSF
310 320 330 340 350
THVELGTSPF FRYNIVPFTL KQWKEAIASN FLFINGTDSW ATTYIENHDQ
360 370 380 390 400
ARSITRFADD SPKYRKISGK LLTLLECSLT GTLYVYQGQE IGQINFKEWP
410 420 430 440 450
IEKYEDVDVK NNYEIIKKSF GKNSKEMKDF FKGIALLSRD HSRTPMPWTK
460 470 480 490 500
DKPNAGFTGP DVKPWFFLNE SFEQGINVEQ ESRDDDSVLN FWKRALQARK
510 520 530 540 550
KYKELMIYGY DFQFIDLDSD QIFSFTKEYE DKTLFAALNF SGEEIEFSLP
560 570 580
REGASLSFIL GNYDDTDVSS RVLKPWEGRI YLVK
Length:584
Mass (Da):68,142
Last modified:October 1, 1994 - v1
Checksum:i4C461F5F40B464C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36168 Genomic DNA Translation: CAA85264.1
BK006936 Genomic DNA Translation: DAA07415.1
PIRiS46183
RefSeqiNP_009858.3, NM_001178647.3

Genome annotation databases

EnsemblFungiiYBR299W; YBR299W; YBR299W
GeneIDi852602
KEGGisce:YBR299W

Similar proteinsi

Entry informationi

Entry nameiMAL32_YEAST
AccessioniPrimary (citable) accession number: P38158
Secondary accession number(s): D6VQU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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