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UniProtKB - P38145 (RISA_YEAST)
Protein
Riboflavin synthase
Gene
RIB5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.
1 PublicationMiscellaneous
Present with 7300 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin1 PublicationEC:2.5.1.91 Publication
: riboflavin biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.1 Publication This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 143 | Lumazine 2By similarity | 1 |
GO - Molecular functioni
- riboflavin synthase activity Source: SGD
GO - Biological processi
- riboflavin biosynthetic process Source: SGD
Keywordsi
Molecular function | Transferase |
Biological process | Riboflavin biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00275;UER00405 |
Names & Taxonomyi
Protein namesi | Recommended name: Riboflavin synthase1 Publication (EC:2.5.1.91 Publication)Short name: RS1 Publication |
Gene namesi | Name:RIB51 Publication Ordered Locus Names:YBR256C ORF Names:YBR1724 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000460, RIB5 |
VEuPathDBi | FungiDB:YBR256C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068174 | 1 – 238 | Riboflavin synthaseAdd BLAST | 238 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 95 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P38145 |
PaxDbi | P38145 |
PRIDEi | P38145 |
PTM databases
iPTMneti | P38145 |
Interactioni
Subunit structurei
Homotrimer.
By similarityProtein-protein interaction databases
BioGRIDi | 32952, 140 interactors |
MINTi | P38145 |
STRINGi | 4932.YBR256C |
Miscellaneous databases
RNActi | P38145, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1 – 103 | Lumazine-binding 1By similarityAdd BLAST | 103 | |
Repeati | 104 – 205 | Lumazine-binding 2By similarityAdd BLAST | 102 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 4 – 6 | Lumazine 1 bindingBy similarity | 3 | |
Regioni | 54 – 56 | Lumazine 2 binding; shared with one trimeric partnerBy similarity | 3 | |
Regioni | 68 – 73 | Lumazine 2 binding; shared with one trimeric partnerBy similarity | 6 | |
Regioni | 107 – 109 | Lumazine 2 binding; shared with one trimeric partnerBy similarity | 3 | |
Regioni | 152 – 154 | Lumazine 1 bindingBy similarity | 3 | |
Regioni | 170 – 175 | Lumazine 1 bindingBy similarity | 6 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3310, Eukaryota |
HOGENOMi | CLU_034388_1_1_1 |
InParanoidi | P38145 |
OMAi | HILSGHV |
Family and domain databases
CDDi | cd00402, Riboflavin_synthase_like, 1 hit |
Gene3Di | 2.40.30.20, 2 hits |
InterProi | View protein in InterPro IPR023366, ATP_synth_asu-like_sf IPR001783, Lumazine-bd IPR026017, Lumazine-bd_dom IPR017938, Riboflavin_synthase-like_b-brl |
PANTHERi | PTHR21098, PTHR21098, 1 hit |
Pfami | View protein in Pfam PF00677, Lum_binding, 2 hits |
PIRSFi | PIRSF000498, Riboflavin_syn_A, 1 hit |
SUPFAMi | SSF63380, SSF63380, 2 hits |
TIGRFAMsi | TIGR00187, ribE, 1 hit |
PROSITEi | View protein in PROSITE PS51177, LUMAZINE_BIND, 2 hits |
i Sequence
Sequence statusi: Complete.
P38145-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFTGIVECMG TVLENNPYDD SESGGQGVSI TIGNAGSILT DCHVGDSIAV
60 70 80 90 100
NGVCLTVTEF NNDSFKVGIS PETIKRSNVA SWIQGTQVNL ERAVSQDVRF
110 120 130 140 150
GGHYVQGHVD TVANIVSRRP EGNSIIFGFQ LRDQEYFKYI VEKGFICIDG
160 170 180 190 200
TSLTIIKVDP LSQGGAFYIS MIKHTQDNVI MPLKKIGDEV NIEVDLTGKI
210 220 230
IEKQILLTLE NQISKKDSTL NTMISNIIEE KVRNYLNK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z21621 Genomic DNA Translation: CAA79745.1 X70529 Genomic DNA Translation: CAA49920.1 Z36125 Genomic DNA Translation: CAA85219.1 BK006936 Genomic DNA Translation: DAA07373.1 |
PIRi | S34072 |
RefSeqi | NP_009815.1, NM_001178604.1 |
Genome annotation databases
EnsemblFungii | YBR256C_mRNA; YBR256C; YBR256C |
GeneIDi | 852559 |
KEGGi | sce:YBR256C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z21621 Genomic DNA Translation: CAA79745.1 X70529 Genomic DNA Translation: CAA49920.1 Z36125 Genomic DNA Translation: CAA85219.1 BK006936 Genomic DNA Translation: DAA07373.1 |
PIRi | S34072 |
RefSeqi | NP_009815.1, NM_001178604.1 |
3D structure databases
AlphaFoldDBi | P38145 |
SMRi | P38145 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32952, 140 interactors |
MINTi | P38145 |
STRINGi | 4932.YBR256C |
PTM databases
iPTMneti | P38145 |
Proteomic databases
MaxQBi | P38145 |
PaxDbi | P38145 |
PRIDEi | P38145 |
Genome annotation databases
EnsemblFungii | YBR256C_mRNA; YBR256C; YBR256C |
GeneIDi | 852559 |
KEGGi | sce:YBR256C |
Organism-specific databases
SGDi | S000000460, RIB5 |
VEuPathDBi | FungiDB:YBR256C |
Phylogenomic databases
eggNOGi | KOG3310, Eukaryota |
HOGENOMi | CLU_034388_1_1_1 |
InParanoidi | P38145 |
OMAi | HILSGHV |
Enzyme and pathway databases
UniPathwayi | UPA00275;UER00405 |
Miscellaneous databases
PROi | PR:P38145 |
RNActi | P38145, protein |
Family and domain databases
CDDi | cd00402, Riboflavin_synthase_like, 1 hit |
Gene3Di | 2.40.30.20, 2 hits |
InterProi | View protein in InterPro IPR023366, ATP_synth_asu-like_sf IPR001783, Lumazine-bd IPR026017, Lumazine-bd_dom IPR017938, Riboflavin_synthase-like_b-brl |
PANTHERi | PTHR21098, PTHR21098, 1 hit |
Pfami | View protein in Pfam PF00677, Lum_binding, 2 hits |
PIRSFi | PIRSF000498, Riboflavin_syn_A, 1 hit |
SUPFAMi | SSF63380, SSF63380, 2 hits |
TIGRFAMsi | TIGR00187, ribE, 1 hit |
PROSITEi | View protein in PROSITE PS51177, LUMAZINE_BIND, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RISA_YEAST | |
Accessioni | P38145Primary (citable) accession number: P38145 Secondary accession number(s): D6VQQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways