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UniProtKB - P38131 (KTR4_YEAST)
Protein
Probable mannosyltransferase KTR4
Gene
KTR4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Miscellaneous
Present with 5240 molecules/cell in log phase SD medium.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 352 | NucleophileSequence analysis | 1 |
GO - Molecular functioni
- alpha-1,2-mannosyltransferase activity Source: GO_Central
- mannosyltransferase activity Source: SGD
GO - Biological processi
- cell wall mannoprotein biosynthetic process Source: GO_Central
- mannosylation Source: GO_Central
- protein N-linked glycosylation Source: SGD
- protein O-linked glycosylation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:KTR4 Ordered Locus Names:YBR199W ORF Names:YBR1411 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000403, KTR4 |
VEuPathDBi | FungiDB:YBR199W |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Golgi apparatus
- Golgi apparatus Source: SGD
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 464 | LumenalSequence analysisAdd BLAST | 432 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208245 | 1 – 464 | Probable mannosyltransferase KTR4Add BLAST | 464 |
Proteomic databases
MaxQBi | P38131 |
PaxDbi | P38131 |
PRIDEi | P38131 |
PTM databases
iPTMneti | P38131 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 32896, 49 interactors |
DIPi | DIP-7838N |
IntActi | P38131, 3 interactors |
MINTi | P38131 |
STRINGi | 4932.YBR199W |
Miscellaneous databases
RNActi | P38131, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P38131 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 33 – 130 | Stem regionBy similarityAdd BLAST | 98 | |
Regioni | 131 – 464 | CatalyticBy similarityAdd BLAST | 334 |
Sequence similaritiesi
Belongs to the glycosyltransferase 15 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4472, Eukaryota |
GeneTreei | ENSGT00940000176287 |
HOGENOMi | CLU_024327_1_1_1 |
InParanoidi | P38131 |
OMAi | WNSGLFY |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
PIRSFi | PIRSF018153, Glyco_trans_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
P38131-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFLSKRILK PVLSVIILIS IAVTVVLYFL TANENYLQAV KDSAKSQYAS
60 70 80 90 100
LRESYKSITG KTESADELPD HDAEVLDSIM DRLHEPLYEK DTFDPNEVLA
110 120 130 140 150
ENKQLYEEFL LQEISEPKVD NLVRSGDPLA GKAKGTILSL VRNSDLEDII
160 170 180 190 200
SSIQQLEEEY NKNFGYPYTF LNDEEFTDEF KDGIKSILPK DRVVEFGTIG
210 220 230 240 250
PDNWNMPDSI DRERYDQEMD KMSKENIQYA EVESYHNMCR FYSKEFYHHP
260 270 280 290 300
LLSKYKYVWR LEPNVNFYCK INYDVFQFMN KNDKIYGFVL NLYDSPQTIE
310 320 330 340 350
TLWTSTMDFV EEHPNYLNVN GAFAWLKDNS QNPKNYDYTQ GYSTCHFWTN
360 370 380 390 400
FEIVDLDFLR SEPYEKYMQY LEEKGGFYYE RWGDAPVRSL ALALFADKSS
410 420 430 440 450
IHWFRDIGYH HTPYTNCPTC PADSDRCNGN CVPGKFTPWS DLDNQNCQAT
460
WIRHSMSEEE LEMY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z21487 Genomic DNA Translation: CAA79686.1 Z36068 Genomic DNA Translation: CAA85161.1 Z36069 Genomic DNA Translation: CAA85163.1 AY692898 Genomic DNA Translation: AAT92917.1 BK006936 Genomic DNA Translation: DAA07315.1 |
PIRi | S34024 |
RefSeqi | NP_009758.3, NM_001178547.3 |
Genome annotation databases
EnsemblFungii | YBR199W_mRNA; YBR199W; YBR199W |
GeneIDi | 852498 |
KEGGi | sce:YBR199W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z21487 Genomic DNA Translation: CAA79686.1 Z36068 Genomic DNA Translation: CAA85161.1 Z36069 Genomic DNA Translation: CAA85163.1 AY692898 Genomic DNA Translation: AAT92917.1 BK006936 Genomic DNA Translation: DAA07315.1 |
PIRi | S34024 |
RefSeqi | NP_009758.3, NM_001178547.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5A07 | X-ray | 1.90 | A/B | 33-464 | [»] | |
5A08 | X-ray | 2.21 | A/B | 33-464 | [»] | |
SMRi | P38131 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32896, 49 interactors |
DIPi | DIP-7838N |
IntActi | P38131, 3 interactors |
MINTi | P38131 |
STRINGi | 4932.YBR199W |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
PTM databases
iPTMneti | P38131 |
Proteomic databases
MaxQBi | P38131 |
PaxDbi | P38131 |
PRIDEi | P38131 |
Genome annotation databases
EnsemblFungii | YBR199W_mRNA; YBR199W; YBR199W |
GeneIDi | 852498 |
KEGGi | sce:YBR199W |
Organism-specific databases
SGDi | S000000403, KTR4 |
VEuPathDBi | FungiDB:YBR199W |
Phylogenomic databases
eggNOGi | KOG4472, Eukaryota |
GeneTreei | ENSGT00940000176287 |
HOGENOMi | CLU_024327_1_1_1 |
InParanoidi | P38131 |
OMAi | WNSGLFY |
Miscellaneous databases
PROi | PR:P38131 |
RNActi | P38131, protein |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
PIRSFi | PIRSF018153, Glyco_trans_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KTR4_YEAST | |
Accessioni | P38131Primary (citable) accession number: P38131 Secondary accession number(s): D6VQJ5, P89506 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families