UniProtKB - P38128 (SMP1_YEAST)
Protein
Transcription factor SMP1
Gene
SMP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transcription factor that controls part of the HOG1-mediated osmostress responses. Binds to the DNA sequence 5'-ACTACTA[TA]4TAG-3'. Does not appear to function in the MPK1 pathway.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 58 – 87 | Mef2-typeSequence analysisAdd BLAST | 30 |
GO - Molecular functioni
- DNA binding, bending Source: SGD
- DNA-binding transcription factor activity Source: SGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: SGD
- transcription factor binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SCE-525793, Myogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SMP1 |
Gene namesi | Name:SMP1 Ordered Locus Names:YBR182C ORF Names:YBR1245 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YBR182C |
SGDi | S000000386, SMP1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199441 | 1 – 452 | Transcription factor SMP1Add BLAST | 452 |
Post-translational modificationi
Phosphorylated by HOG1.1 Publication
Proteomic databases
PaxDbi | P38128 |
PTM databases
iPTMneti | P38128 |
Interactioni
Subunit structurei
Can heterodimerize with RLM1.
Interacts with HOG1.
1 PublicationGO - Molecular functioni
- protein dimerization activity Source: InterPro
- transcription factor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 32880, 113 interactors |
IntActi | P38128, 4 interactors |
MINTi | P38128 |
STRINGi | 4932.YBR182C |
Miscellaneous databases
RNActi | P38128, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 57 | MADS-boxPROSITE-ProRule annotationAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 99 – 105 | Poly-Arg | 7 |
Sequence similaritiesi
Belongs to the MEF2 family.Curated
Phylogenomic databases
eggNOGi | KOG0014, Eukaryota |
GeneTreei | ENSGT00940000169350 |
HOGENOMi | CLU_605820_0_0_1 |
InParanoidi | P38128 |
OMAi | ATNDACQ |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P38128-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRRKIEIEP IKDDRNRTVT FIKRKAGLFK KAHELSVLCQ VDIAVIILGS
60 70 80 90 100
NNTFYEYSSV DMSNLLNVHQ NNTDLPHNII EPSDYGDYVK KPRVVLNERK
110 120 130 140 150
RRRRRATVLQ PASHSGSCTV SSQDSSSVQN NGNLSAPLAS NDAGNAGVST
160 170 180 190 200
PLVHCHGAIS RSGSNHSDCA RNSADYQMLQ GGLNSGGSFH ANDYKESVDQ
210 220 230 240 250
QHVANEAIHR NFMNKRIRPD THLLLSESNH SNYHNFYPSP YENLPKPSLP
260 270 280 290 300
ASLVGNIPSF QSQFVQVIPA NSNPMGKGFN GTGDSESFEA KQKIHPTVAI
310 320 330 340 350
SNTLEGPAPV QAMVHHLHQL NSNRGKLSGK PYLKLNIPKA TNDACQRSPA
360 370 380 390 400
MYSGTASPKT DVQATPNQML ASNMSSPLSR SKFLGFKNND MDDLYHNGRC
410 420 430 440 450
GSTYVNNKTF FLKPPIGRPP KFPKSPSSSI VVFPSSVASS TLKSTSSTNS
PD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36051 Genomic DNA Translation: CAA85143.1 AY693072 Genomic DNA Translation: AAT93091.1 U02073 Genomic DNA Translation: AAB60287.1 BK006936 Genomic DNA Translation: DAA07296.1 |
PIRi | S46054 |
RefSeqi | NP_009741.3, NM_001178530.3 |
Genome annotation databases
EnsemblFungii | YBR182C_mRNA; YBR182C; YBR182C |
GeneIDi | 852480 |
KEGGi | sce:YBR182C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36051 Genomic DNA Translation: CAA85143.1 AY693072 Genomic DNA Translation: AAT93091.1 U02073 Genomic DNA Translation: AAB60287.1 BK006936 Genomic DNA Translation: DAA07296.1 |
PIRi | S46054 |
RefSeqi | NP_009741.3, NM_001178530.3 |
3D structure databases
SMRi | P38128 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32880, 113 interactors |
IntActi | P38128, 4 interactors |
MINTi | P38128 |
STRINGi | 4932.YBR182C |
PTM databases
iPTMneti | P38128 |
Proteomic databases
PaxDbi | P38128 |
Genome annotation databases
EnsemblFungii | YBR182C_mRNA; YBR182C; YBR182C |
GeneIDi | 852480 |
KEGGi | sce:YBR182C |
Organism-specific databases
EuPathDBi | FungiDB:YBR182C |
SGDi | S000000386, SMP1 |
Phylogenomic databases
eggNOGi | KOG0014, Eukaryota |
GeneTreei | ENSGT00940000169350 |
HOGENOMi | CLU_605820_0_0_1 |
InParanoidi | P38128 |
OMAi | ATNDACQ |
Enzyme and pathway databases
Reactomei | R-SCE-525793, Myogenesis |
Miscellaneous databases
PROi | PR:P38128 |
RNActi | P38128, protein |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMP1_YEAST | |
Accessioni | P38128Primary (citable) accession number: P38128 Secondary accession number(s): D6VQH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names