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UniProtKB - P38126 (PCH2_YEAST)
Protein
Pachytene checkpoint protein 2
Gene
PCH2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for the pachytene checkpoint, the meiotic checkpoint that prevents chromosome segregation when defects in recombination and synaptonemal complex formation occurred. Represses meiotic recombination in the rDNA, probably by excluding the meiosis-specific protein HOP1 from the nucleolar region.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 314 – 321 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: SGD
GO - Biological processi
- meiotic DNA double-strand break formation Source: SGD
- meiotic recombination checkpoint signaling Source: SGD
- reciprocal meiotic recombination Source: SGD
Keywordsi
Biological process | Meiosis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Pachytene checkpoint protein 2 |
Gene namesi | Name:PCH2 Ordered Locus Names:YBR186W ORF Names:YBR1308 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000390, PCH2 |
VEuPathDBi | FungiDB:YBR186W |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Other locations
- Chromosome 1 Publication
Note: The majority of the protein localizes to the nucleolar region containing the ribosomal RNA genes (rDNA), a tandem array of 100-150 repeats on chromosome XII. Localization is SIR2-dependent.
Nucleus
Other locations
- chromosome Source: GO_Central
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084789 | 1 – 564 | Pachytene checkpoint protein 2Add BLAST | 564 |
Proteomic databases
PaxDbi | P38126 |
PTM databases
iPTMneti | P38126 |
Expressioni
Inductioni
Induced at the onset of meiosis I and reaches a maximum level during pachytene (at protein level).1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 32884, 70 interactors |
DIPi | DIP-4661N |
IntActi | P38126, 4 interactors |
MINTi | P38126 |
STRINGi | 4932.YBR186W |
Miscellaneous databases
RNActi | P38126, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0744, Eukaryota |
GeneTreei | ENSGT00940000170021 |
HOGENOMi | CLU_028208_3_0_1 |
InParanoidi | P38126 |
OMAi | VCIEEMI |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR027417, P-loop_NTPase IPR044539, Pch2-like |
PANTHERi | PTHR45991, PTHR45991, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
i Sequence
Sequence statusi: Complete.
P38126-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYIVDLQVR GSSLRVIKCM FREDEQISSL HSGSDSKQNS NKKLGEFLNL
60 70 80 90 100
LKAVVKRKLE SFPKDRLKTS IITGQELMRE GQGSIEIKDP PTEAQQHLIR
110 120 130 140 150
SLAKVLLHQF SSINGKVNTV NEGQDNLFLS LFVKKISIEQ QSTSHVSIKL
160 170 180 190 200
NFHEKINLGQ HIDSILDSEE TNESDTYHMG SVDEFIIYPF CCLEEQDELK
210 220 230 240 250
NGSILSTEFD KIDLELDEDD GFEGETLNNC INSVGNFDIP LSKQTLNLVN
260 270 280 290 300
ISYLPGTTFE GQWESLYFGN NIKERLYSYA TISLKIARFK QTGDSNQEDI
310 320 330 340 350
TTLITNNKLL LVHGPPGTGK TTLCKALCQK LSVRREFSDG SDTIDTNYKG
360 370 380 390 400
IIIELSCARI FSKWFGESSK NISIVFKDIE ELLKVNEGRG IFICLLIDEV
410 420 430 440 450
EAIASSRTNL SSRNESTDGI RVVNTLLTQL DRLKKYHNFL ALATSNLLDS
460 470 480 490 500
LDDAFVDRAD GVFYVGNPTA EGILHILKVC IEEMITSGII LFHARSTGVK
510 520 530 540 550
FFNKYQDILR KIAIKCSTVD ISGRTIRKLP LMCLSEYFRT FPVDDDEFVL
560
ALAMSARKLS AARK
Sequence cautioni
The sequence AAB60280 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA85147 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02073 Genomic DNA Translation: AAB60280.1 Sequence problems. Z36055 Genomic DNA Translation: CAA85147.1 Sequence problems. BK006936 Genomic DNA Translation: DAA07301.1 |
PIRi | S46058 |
RefSeqi | NP_009745.2, NM_001178534.1 |
Genome annotation databases
EnsemblFungii | YBR186W_mRNA; YBR186W; YBR186W |
GeneIDi | 852484 |
KEGGi | sce:YBR186W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02073 Genomic DNA Translation: AAB60280.1 Sequence problems. Z36055 Genomic DNA Translation: CAA85147.1 Sequence problems. BK006936 Genomic DNA Translation: DAA07301.1 |
PIRi | S46058 |
RefSeqi | NP_009745.2, NM_001178534.1 |
3D structure databases
SMRi | P38126 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32884, 70 interactors |
DIPi | DIP-4661N |
IntActi | P38126, 4 interactors |
MINTi | P38126 |
STRINGi | 4932.YBR186W |
PTM databases
iPTMneti | P38126 |
Proteomic databases
PaxDbi | P38126 |
Genome annotation databases
EnsemblFungii | YBR186W_mRNA; YBR186W; YBR186W |
GeneIDi | 852484 |
KEGGi | sce:YBR186W |
Organism-specific databases
SGDi | S000000390, PCH2 |
VEuPathDBi | FungiDB:YBR186W |
Phylogenomic databases
eggNOGi | KOG0744, Eukaryota |
GeneTreei | ENSGT00940000170021 |
HOGENOMi | CLU_028208_3_0_1 |
InParanoidi | P38126 |
OMAi | VCIEEMI |
Miscellaneous databases
PROi | PR:P38126 |
RNActi | P38126, protein |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR027417, P-loop_NTPase IPR044539, Pch2-like |
PANTHERi | PTHR45991, PTHR45991, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PCH2_YEAST | |
Accessioni | P38126Primary (citable) accession number: P38126 Secondary accession number(s): D6VQI1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - SIMILARITY comments
Index of protein domains and families