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UniProtKB - P38125 (DTR1_YEAST)
Protein
Dityrosine transporter 1
Gene
DTR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore.
1 PublicationGO - Molecular functioni
- amine transmembrane transporter activity Source: SGD
- xenobiotic transmembrane transporter activity Source: GO_Central
GO - Biological processi
- amine transport Source: SGD
- ascospore wall assembly Source: SGD
- transmembrane transport Source: SGD
- xenobiotic detoxification by transmembrane export across the plasma membrane Source: GO_Central
Keywordsi
Biological process | Sporulation, Transport |
Protein family/group databases
TCDBi | 2.A.1.2.40, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Dityrosine transporter 1 |
Gene namesi | Name:DTR1 Ordered Locus Names:YBR180W ORF Names:YBR1242 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000384, DTR1 |
VEuPathDBi | FungiDB:YBR180W |
Subcellular locationi
Other locations
- Prospore membrane 5 Publications; Multi-pass membrane protein 5 Publications
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: GO_Central
- prospore membrane Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 110 | CytoplasmicSequence analysisAdd BLAST | 110 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 132 – 149 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 184 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 206 – 207 | ExtracellularSequence analysis | 2 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 240 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 241 – 261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 267 | ExtracellularSequence analysis | 6 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 289 – 366 | CytoplasmicSequence analysisAdd BLAST | 78 | |
Transmembranei | 367 – 387 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 388 – 398 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 399 – 419 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 420 – 446 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 447 – 469 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 470 – 472 | ExtracellularSequence analysis | 3 | |
Transmembranei | 473 – 493 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 494 – 520 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 521 – 541 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 542 | ExtracellularSequence analysis | 1 | |
Transmembranei | 543 – 563 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 564 – 572 | CytoplasmicSequence analysis | 9 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173438 | 1 – 572 | Dityrosine transporter 1Add BLAST | 572 |
Post-translational modificationi
Phosphorylated.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P38125 |
Expressioni
Inductioni
During sporulation.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 32878, 50 interactors |
DIPi | DIP-5179N |
IntActi | P38125, 4 interactors |
MINTi | P38125 |
STRINGi | 4932.YBR180W |
Miscellaneous databases
RNActi | P38125, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 49 – 95 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 548 – 572 | Required for the localization to the prospore membraneAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 28 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
HOGENOMi | CLU_008455_8_7_1 |
InParanoidi | P38125 |
OMAi | GMTWCSN |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P38125-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA
60 70 80 90 100
NIDHDVFHEH PDSSPSLSAQ KAKTKEEEVA VKSSNSQSRD PSPDTQAHIP
110 120 130 140 150
YTYFSKDQRL IIFGIIIFIG FLGPMSGNIY IPALPLLQRE YDVSATTINA
160 170 180 190 200
TVSVFMAVFS VGPLFWGALA DFGGRKFLYM VSLSLMLIVN ILLAAVPVNI
210 220 230 240 250
AALFVLRIFQ AFASSSVISL GAGTVTDVVP PKHRGKAIAY FMMGPNMGPI
260 270 280 290 300
IAPIVAGLIL MKGNYWRWLF GFTSIMTGIA LILVTALLPE TLRCIVGNGD
310 320 330 340 350
PKWGDKKDER ENNESPFFEG NKISHRRLFP DIGIRKPVNN DAFFQENFPK
360 370 380 390 400
PPKAGLTLYW KMIKCPPIII TSVSTALLFS SYYAFSVTFS YYLEHDYRFT
410 420 430 440 450
MLEIGAAYVC PGVAMLLGSQ SGGHLSDYLR SRWIKSHPKK KFPAEFRLLL
460 470 480 490 500
NLIGILLTIC GTIGYGWAIF FHYHFVVLLV FSALTAFGMT WCSNTSMTYL
510 520 530 540 550
TELFPKRAAG TVAVSSFFRN VGAAISSAII LQLCNAMGIG WCFTGLGLCS
560 570
SISLIGILYL LIFQRKYTAK EF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36049 Genomic DNA Translation: CAA85141.1 BK006936 Genomic DNA Translation: DAA07294.1 |
PIRi | S46051 |
RefSeqi | NP_009739.1, NM_001178528.1 |
Genome annotation databases
EnsemblFungii | YBR180W_mRNA; YBR180W; YBR180W |
GeneIDi | 852478 |
KEGGi | sce:YBR180W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z36049 Genomic DNA Translation: CAA85141.1 BK006936 Genomic DNA Translation: DAA07294.1 |
PIRi | S46051 |
RefSeqi | NP_009739.1, NM_001178528.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 32878, 50 interactors |
DIPi | DIP-5179N |
IntActi | P38125, 4 interactors |
MINTi | P38125 |
STRINGi | 4932.YBR180W |
Protein family/group databases
TCDBi | 2.A.1.2.40, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P38125 |
Genome annotation databases
EnsemblFungii | YBR180W_mRNA; YBR180W; YBR180W |
GeneIDi | 852478 |
KEGGi | sce:YBR180W |
Organism-specific databases
SGDi | S000000384, DTR1 |
VEuPathDBi | FungiDB:YBR180W |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
HOGENOMi | CLU_008455_8_7_1 |
InParanoidi | P38125 |
OMAi | GMTWCSN |
Miscellaneous databases
PROi | PR:P38125 |
RNActi | P38125, protein |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DTR1_YEAST | |
Accessioni | P38125Primary (citable) accession number: P38125 Secondary accession number(s): D6VQH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - SIMILARITY comments
Index of protein domains and families