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UniProtKB - P38117 (ETFB_HUMAN)

Entry version 196 (13 Feb 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Electron transfer flavoprotein subunit beta

Gene

ETFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:25416781, PubMed:15159392, PubMed:15975918). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:8962055, PubMed:15159392, PubMed:15975918).1 PublicationCurated6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei9AMP; via carbonyl oxygenCombined sources3 Publications1
Binding sitei66AMP; via amide nitrogen and carbonyl oxygenCombined sources3 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi39 – 42AMPCombined sources3 Publications4
Nucleotide bindingi123 – 134AMPCombined sources3 PublicationsAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-611105 Respiratory electron transport
R-HSA-8876725 Protein methylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electron transfer flavoprotein subunit betaCurated
Short name:
Beta-ETF1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ETFBImported
ORF Names:FP585
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000105379.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:3482 ETFB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		130410 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P38117

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glutaric aciduria 2B (GA2B)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.
See also OMIM:231680
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025804128D → N in GA2B; decreased protein stability. 1 PublicationCorresponds to variant dbSNP:rs104894678EnsemblClinVar.1
Natural variantiVAR_002369164R → Q in GA2B; reduced electron transfer activity. 1 PublicationCorresponds to variant dbSNP:rs104894677EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi165E → A or Q: Drastically increases interprotein electron transfer rates. 1 Publication1
Mutagenesisi195L → A: Severely impaired in complex formation with ACADM. 1 Publication1
Mutagenesisi200 – 203KAKK → RAKR: Does not abolish electron transfer activity. Abolishes sensitivity to inhibition by lysine methyltransferase ETFBKMT. 1 Publication4
Mutagenesisi200 – 202KAK → RAR: Does not abolish methylation by ETFBKMT. 1 Publication3
Mutagenesisi200K → R: Does not abolish electron transfer activity. Decreases sensitivity to inhibition by lysine methyltransferase ETFBKMT. 1 Publication1
Mutagenesisi203K → R: Does not abolish electron transfer activity. Decreases sensitivity to inhibition by lysine methyltransferase ETFBKMT. 1 Publication1

Keywords - Diseasei

Disease mutation, Glutaricaciduria

Organism-specific databases

DisGeNET

More...DisGeNETi		2109

MalaCards human disease database

More...MalaCardsi		ETFB
MIMi231680 phenotype

Open Targets

More...OpenTargetsi		ENSG00000105379

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		394532 Multiple acyl-CoA dehydrogenase deficiency, mild type
394529 Multiple acyl-CoA dehydrogenase deficiency, severe neonatal type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27898

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ETFB

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001678702 – 255Electron transfer flavoprotein subunit betaAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei200N6,N6,N6-trimethyllysine; by ETFBKMT; alternate2 Publications1
Modified residuei200N6-acetyllysine; alternateBy similarity1
Modified residuei200N6-methyllysine; alternateCombined sources1
Modified residuei203N6,N6,N6-trimethyllysine; by ETFBKMT2 Publications1
Modified residuei210N6-acetyllysine; alternateBy similarity1
Modified residuei210N6-succinyllysine; alternateBy similarity1
Modified residuei223PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei238N6-acetyllysineBy similarity1
Modified residuei248N6-acetyllysine; alternateBy similarity1
Modified residuei248N6-succinyllysine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated. Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases.2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P38117

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P38117

MaxQB - The MaxQuant DataBase

More...MaxQBi		P38117

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P38117

PeptideAtlas

More...PeptideAtlasi		P38117

PRoteomics IDEntifications database

More...PRIDEi		P38117

ProteomicsDB human proteome resource

More...ProteomicsDBi		55282
55283 [P38117-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P38117-1 [P38117-1]
P38117-2 [P38117-2]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00004902

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P38117

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P38117

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P38117

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P38117

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105379 Expressed in 236 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P38117 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P38117 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA018910
HPA018921
HPA018923

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of ETFA and ETFB (PubMed:25023281, PubMed:25416781, PubMed:8962055, PubMed:15159392, PubMed:15975918). Identified in a complex that contains ETFA, ETFB and ETFRF1 (PubMed:27499296). Interacts with ACADM (PubMed:15159392, PubMed:15975918).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108410, 37 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2731 Electron transfer flavoprotein complex

Database of interacting proteins

More...DIPi		DIP-6162N

Protein interaction database and analysis system

More...IntActi		P38117, 32 interactors

Molecular INTeraction database

More...MINTi		P38117

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346173

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EFVX-ray2.10B1-255[»]
1T9GX-ray2.90S1-255[»]
2A1TX-ray2.80S1-255[»]
2A1UX-ray2.11B1-255[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P38117

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P38117

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P38117

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 205Recognition loop2 PublicationsAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The recognition loop recognizes a hydrophobic patch at the surface of interacting dehydrogenases and acts as a static anchor at the interface.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETF beta-subunit/FixA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3180 Eukaryota
COG2086 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009936

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000247877

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG005614

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P38117

KEGG Orthology (KO)

More...KOi		K03521

Identification of Orthologs from Complete Genome Data

More...OMAi		RIPNMRG

Database of Orthologous Groups

More...OrthoDBi		1092876at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P38117

TreeFam database of animal gene trees

More...TreeFami		TF314039

Family and domain databases

Conserved Domains Database

More...CDDi		cd01714 ETF_beta, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000049 ET-Flavoprotein_bsu_CS
IPR014730 ETF_a/b_N
IPR012255 ETF_b
IPR033948 ETF_beta_N
IPR014729 Rossmann-like_a/b/a_fold

The PANTHER Classification System

More...PANTHERi		PTHR21294 PTHR21294, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01012 ETF, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000090 Beta-ETF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00893 ETF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01065 ETF_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P38117-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELRVLVAV KRVIDYAVKI RVKPDRTGVV TDGVKHSMNP FCEIAVEEAV 
        60         70         80         90        100
RLKEKKLVKE VIAVSCGPAQ CQETIRTALA MGADRGIHVE VPPAEAERLG 
       110        120        130        140        150
PLQVARVLAK LAEKEKVDLV LLGKQAIDDD CNQTGQMTAG FLDWPQGTFA 
       160        170        180        190        200
SQVTLEGDKL KVEREIDGGL ETLRLKLPAV VTADLRLNEP RYATLPNIMK 
       210        220        230        240        250
AKKKKIEVIK PGDLGVDLTS KLSVISVEDP PQRTAGVKVE TTEDLVAKLK 

EIGRI
Length:255
Mass (Da):27,844
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47E6EAEF50EB2C80
GO
Isoform 2 (identifier: P38117-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MAELRVLVAVKRVIDYAVK → MYLSLWVTIN...DPTPSPPAGQ

Show »
Length:346
Mass (Da):37,434
Checksum:i29C992C07350130A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY67M0QY67_HUMAN
Electron transfer flavoprotein subu...
ETFB
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti198I → S in CAB37832 (PubMed:7912128).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025804128D → N in GA2B; decreased protein stability. 1 PublicationCorresponds to variant dbSNP:rs104894678EnsemblClinVar.1
Natural variantiVAR_008548154T → M3 PublicationsCorresponds to variant dbSNP:rs1130426EnsemblClinVar.1
Natural variantiVAR_002369164R → Q in GA2B; reduced electron transfer activity. 1 PublicationCorresponds to variant dbSNP:rs104894677EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0178501 – 19MAELR…DYAVK → MYLSLWVTINTVNLRNTLSG LRGAVTTVGMIKSDVPGTQE WLDERRRQGDLPLPTNSNPV LSLELCDPGQGPAPFQAVVV LIQPGRGLALRPPPSCLFPP DPTPSPPAGQ in isoform 2. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X71129 mRNA Translation: CAA50441.1
AF436663
, AF436658, AF436659, AF436660, AF436661, AF436662 Genomic DNA Translation: AAN03713.1
AF370381 mRNA Translation: AAQ15217.1
CR456827 mRNA Translation: CAG33108.1
AK055285 mRNA Translation: BAG51494.1
AK291881 mRNA Translation: BAF84570.1
BC093961 mRNA Translation: AAH93961.1
BC093963 mRNA Translation: AAH93963.1
X76067 Genomic DNA Translation: CAB37832.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12828.1 [P38117-1]
CCDS33085.1 [P38117-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S32482

NCBI Reference Sequences

More...RefSeqi		NP_001014763.1, NM_001014763.1 [P38117-2]
NP_001976.1, NM_001985.2 [P38117-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.348531

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309244; ENSP00000311930; ENSG00000105379 [P38117-1]
ENST00000354232; ENSP00000346173; ENSG00000105379 [P38117-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2109

UCSC genome browser

More...UCSCi		uc002pwg.4 human [P38117-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71129 mRNA Translation: CAA50441.1
AF436663
, AF436658, AF436659, AF436660, AF436661, AF436662 Genomic DNA Translation: AAN03713.1
AF370381 mRNA Translation: AAQ15217.1
CR456827 mRNA Translation: CAG33108.1
AK055285 mRNA Translation: BAG51494.1
AK291881 mRNA Translation: BAF84570.1
BC093961 mRNA Translation: AAH93961.1
BC093963 mRNA Translation: AAH93963.1
X76067 Genomic DNA Translation: CAB37832.1
CCDSiCCDS12828.1 [P38117-1]
CCDS33085.1 [P38117-2]
PIRiS32482
RefSeqiNP_001014763.1, NM_001014763.1 [P38117-2]
NP_001976.1, NM_001985.2 [P38117-1]
UniGeneiHs.348531

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EFVX-ray2.10B1-255[»]
1T9GX-ray2.90S1-255[»]
2A1TX-ray2.80S1-255[»]
2A1UX-ray2.11B1-255[»]
ProteinModelPortaliP38117
SMRiP38117
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108410, 37 interactors
ComplexPortaliCPX-2731 Electron transfer flavoprotein complex
DIPiDIP-6162N
IntActiP38117, 32 interactors
MINTiP38117
STRINGi9606.ENSP00000346173

PTM databases

iPTMnetiP38117
PhosphoSitePlusiP38117
SwissPalmiP38117

Polymorphism and mutation databases

BioMutaiETFB

2D gel databases

REPRODUCTION-2DPAGEiIPI00004902
UCD-2DPAGEiP38117

Proteomic databases

EPDiP38117
jPOSTiP38117
MaxQBiP38117
PaxDbiP38117
PeptideAtlasiP38117
PRIDEiP38117
ProteomicsDBi55282
55283 [P38117-2]
TopDownProteomicsiP38117-1 [P38117-1]
P38117-2 [P38117-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309244; ENSP00000311930; ENSG00000105379 [P38117-1]
ENST00000354232; ENSP00000346173; ENSG00000105379 [P38117-2]
GeneIDi2109
KEGGihsa:2109
UCSCiuc002pwg.4 human [P38117-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2109
DisGeNETi2109
EuPathDBiHostDB:ENSG00000105379.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		ETFB
HGNCiHGNC:3482 ETFB
HPAiHPA018910
HPA018921
HPA018923
MalaCardsiETFB
MIMi130410 gene
231680 phenotype
neXtProtiNX_P38117
OpenTargetsiENSG00000105379
Orphaneti394532 Multiple acyl-CoA dehydrogenase deficiency, mild type
394529 Multiple acyl-CoA dehydrogenase deficiency, severe neonatal type
PharmGKBiPA27898

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3180 Eukaryota
COG2086 LUCA
GeneTreeiENSGT00390000009936
HOGENOMiHOG000247877
HOVERGENiHBG005614
InParanoidiP38117
KOiK03521
OMAiRIPNMRG
OrthoDBi1092876at2759
PhylomeDBiP38117
TreeFamiTF314039

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-8876725 Protein methylation

Miscellaneous databases

EvolutionaryTraceiP38117

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ETFB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2109

Protein Ontology

More...PROi		PR:P38117

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105379 Expressed in 236 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiP38117 baseline and differential
GenevisibleiP38117 HS

Family and domain databases

CDDicd01714 ETF_beta, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR000049 ET-Flavoprotein_bsu_CS
IPR014730 ETF_a/b_N
IPR012255 ETF_b
IPR033948 ETF_beta_N
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21294 PTHR21294, 1 hit
PfamiView protein in Pfam
PF01012 ETF, 1 hit
PIRSFiPIRSF000090 Beta-ETF, 1 hit
SMARTiView protein in SMART
SM00893 ETF, 1 hit
PROSITEiView protein in PROSITE
PS01065 ETF_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETFB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38117
Secondary accession number(s): A8K766
, B3KNY2, Q6IBH7, Q71RF6, Q9Y3S7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 196 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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