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Protein

Alcohol dehydrogenase 5

Gene

ADH5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi183Zinc 1; catalyticBy similarity1
Binding sitei205NADBy similarity1
Binding sitei210NADBy similarity1
Binding sitei344NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi181 – 187NADBy similarity7
Nucleotide bindingi272 – 274NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • amino acid catabolic process to alcohol via Ehrlich pathway Source: SGD
  • ethanol biosynthetic process involved in glucose fermentation to ethanol Source: SGD
  • NADH oxidation Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YBR145W-MONOMER
YEAST:YBR145W-MONOMER
SABIO-RKiP38113

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 5 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase V
Gene namesi
Name:ADH5
Ordered Locus Names:YBR145W
ORF Names:YBR1122
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR145W
SGDiS000000349 ADH5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607331 – 351Alcohol dehydrogenase 5Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226PhosphothreonineBy similarity1
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei282PhosphoserineBy similarity1
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei319PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38113
PaxDbiP38113
PRIDEiP38113

PTM databases

iPTMnetiP38113

Interactioni

Protein-protein interaction databases

BioGridi32844, 118 interactors
DIPiDIP-4500N
IntActiP38113, 3 interactors
STRINGi4932.YBR145W

Structurei

3D structure databases

ProteinModelPortaliP38113
SMRiP38113
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000075207
HOGENOMiHOG000294685
InParanoidiP38113
KOiK13953
OMAiSAVAPIM
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P38113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQVIPEKQ KAIVFYETDG KLEYKDVTVP EPKPNEILVH VKYSGVCHSD
60 70 80 90 100
LHAWHGDWPF QLKFPLIGGH EGAGVVVKLG SNVKGWKVGD FAGIKWLNGT
110 120 130 140 150
CMSCEYCEVG NESQCPYLDG TGFTHDGTFQ EYATADAVQA AHIPPNVNLA
160 170 180 190 200
EVAPILCAGI TVYKALKRAN VIPGQWVTIS GACGGLGSLA IQYALAMGYR
210 220 230 240 250
VIGIDGGNAK RKLFEQLGGE IFIDFTEEKD IVGAIIKATN GGSHGVINVS
260 270 280 290 300
VSEAAIEAST RYCRPNGTVV LVGMPAHAYC NSDVFNQVVK SISIVGSCVG
310 320 330 340 350
NRADTREALD FFARGLIKSP IHLAGLSDVP EIFAKMEKGE IVGRYVVETS

K
Length:351
Mass (Da):37,648
Last modified:October 1, 1994 - v1
Checksum:iF4084DAD1E3C19DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36014 Genomic DNA Translation: CAA85103.1
BK006936 Genomic DNA Translation: DAA07260.1
PIRiS46016
RefSeqiNP_009703.3, NM_001178493.3

Genome annotation databases

EnsemblFungiiYBR145W; YBR145W; YBR145W
GeneIDi852442
KEGGisce:YBR145W

Similar proteinsi

Entry informationi

Entry nameiADH5_YEAST
AccessioniPrimary (citable) accession number: P38113
Secondary accession number(s): D6VQE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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