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Entry version 188 (26 Feb 2020)
Sequence version 1 (01 Oct 1994)
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Protein

Serine/threonine-protein kinase MEC1

Gene

MEC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited in complex with protein LCD1 by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Phosphorylates LCD1 and RPA2, a subunit of RPA, involved in DNA replication, repair and recombination. Phosphorylates RAD9, CHK1 and RAD53, which leads to the activation of the CHK1 and RAD53 kinases involved in DNA damage repair cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are proteins involved in genome stability. Required for cell growth and meiotic recombination.12 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage, DNA repair, Meiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-29090-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase MEC1 (EC:2.7.11.1)
Alternative name(s):
ATR homolog
DNA-damage checkpoint kinase MEC1
Mitosis entry checkpoint protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEC1
Synonyms:ESR1, SAD3
Ordered Locus Names:YBR136W
ORF Names:YBR1012
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YBR136W

Saccharomyces Genome Database

More...
SGDi
S000000340 MEC1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi225V → G in MEC1-101; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with P-552 and S-781. 1 Publication1
Mutagenesisi552S → P in MEC1-101; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-225 and S-781. 1 Publication1
Mutagenesisi781L → S in MEC1-101; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-225 and P-552. 1 Publication1
Mutagenesisi1179F → S in MEC1-100; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-1700. 1 Publication1
Mutagenesisi1700N → S in MEC1-100; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-1179. 1 Publication1
Mutagenesisi2224D → A: Impairs kinase activity; when associated with K-2229. 2 Publications1
Mutagenesisi2229N → K: Impairs kinase activity; when associated with A-2224. 1 Publication1
Mutagenesisi2243D → E: Impairs kinase activity. 1 Publication1
Mutagenesisi2360 – 2362MYI → AAA in MEC1-85; disrupts interaction with RFA1 and severely impairs kinase activity. 1 Publication3
Mutagenesisi2367 – 2368FW → AA in MEC1-87; decreases the level of MEC1 and impairs viability. 1 Publication2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888361 – 2368Serine/threonine-protein kinase MEC1Add BLAST2368

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P38111

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38111

PRoteomics IDEntifications database

More...
PRIDEi
P38111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P38111

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Induced during meiosis.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LCD1, which is required for localization MEC1 to the RPA complex.

Interacts directly with the RPA subunits RFA1 and RFA2.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32836, 367 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3621 ATR-ATRIP DNA damage-sensing kinase complex

Database of interacting proteins

More...
DIPi
DIP-799N

Protein interaction database and analysis system

More...
IntActi
P38111, 23 interactors

Molecular INTeraction database

More...
MINTi
P38111

STRING: functional protein association networks

More...
STRINGi
4932.YBR136W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P38111 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P38111

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1399 – 1944FATPROSITE-ProRule annotationAdd BLAST546
Domaini2082 – 2368PI3K/PI4KPROSITE-ProRule annotationAdd BLAST287
Domaini2336 – 2368FATCPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2140 – 2368Binding to the RPA complexAdd BLAST229

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000178_4_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P38111

KEGG Orthology (KO)

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KOi
K02543

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLVCSCT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR011990 TPR-like_helical_dom_sf
IPR012993 UME

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESHVKYLDE LILAIKDLNS GVDSKVQIKK VPTDPSSSQE YAKSLKILNT
60 70 80 90 100
LIRNLKDQRR NNIMKNDTIF SKTVSALALL LEYNPFLLVM KDSNGNFEIQ
110 120 130 140 150
RLIDDFLNIS VLNYDNYHRI WFMRRKLGSW CKACVEFYGK PAKFQLTAHF
160 170 180 190 200
ENTMNLYEQA LTEVLLGKTE LLKFYDTLKG LYILLYWFTS EYSTFGNSIA
210 220 230 240 250
FLDSSLGFTK FDFNFQRLIR IVLYVFDSCE LAALEYAEIQ LKYISLVVDY
260 270 280 290 300
VCNRTISTAL DAPALVCCEQ LKFVLTTMHH FLDNKYGLLD NDPTMAKGIL
310 320 330 340 350
RLYSLCISND FSKCFVDHFP IDQWADFSQS EHFPFTQLTN KALSIVYFDL
360 370 380 390 400
KRRSLPVEAL KYDNKFNIWV YQSEPDSSLK NVTSPFDDRY KQLEKLRLLV
410 420 430 440 450
LKKFNKTERG TLLKYRVNQL SPGFFQRAGN DFKLILNEAS VSIQTCFKTN
460 470 480 490 500
NITRLTSWTV ILGRLACLES EKFSGTLPNS TKDMDNWYVC HLCDIEKTGN
510 520 530 540 550
PFVRINPNRP EAAGKSEIFR ILHSNFLSHP NIDEFSESLL SGILFSLHRI
560 570 580 590 600
FSHFQPPKLT DGNGQINKSF KLVQKCFMNS NRYLRLLSTR IIPLFNISDS
610 620 630 640 650
HNSEDEHTAT LIKFLQSQKL PVVKENLVIA WTQLTLTTSN DVFDTLLLKL
660 670 680 690 700
IDIFNSDDYS LRIMMTLQIK NMAKILKKTP YQLLSPILPV LLRQLGKNLV
710 720 730 740 750
ERKVGFQNLI ELLGYSSKTI LDIFQRYIIP YAIIQYKSDV LSEIAKIMCD
760 770 780 790 800
GDTSLINQMK VNLLKKNSRQ IFAVALVKHG LFSLDILETL FLNRAPTFDK
810 820 830 840 850
GYITAYLPDY KTLAEITKLY KNSVTKDASD SENANMILCS LRFLITNFEK
860 870 880 890 900
DKRHGSKYKN INNWTDDQEQ AFQKKLQDNI LGIFQVFSSD IHDVEGRTTY
910 920 930 940 950
YEKLRVINGI SFLIIYAPKK SIISALAQIS ICLQTGLGLK EVRYEAFRCW
960 970 980 990 1000
HLLVRHLNDE ELSTVIDSLI AFILQKWSEF NGKLRNIVYS ILDTLIKEKS
1010 1020 1030 1040 1050
DLILKLKPYT TLALVGKPEL GILARDGQFA RMVNKIRSTT DLIPIFANNL
1060 1070 1080 1090 1100
KSSNKYVINQ NLDDIEVYLR RKQTERSIDF TPKKVGQTSD ITLVLGALLD
1110 1120 1130 1140 1150
TSHKFRNLDK DLCEKCAKCI SMIGVLDVTK HEFKRTTYSE NEVYDLNDSV
1160 1170 1180 1190 1200
QTIKFLIWVI NDILVPAFWQ SENPSKQLFV ALVIQESLKY CGLSSESWDM
1210 1220 1230 1240 1250
NHKELYPNEA KLWEKFNSVS KTTIYPLLSS LYLAQSWKEY VPLKYPSNNF
1260 1270 1280 1290 1300
KEGYKIWVKR FTLDLLKTGT TENHPLHVFS SLIREDDGSL SNFLLPYISL
1310 1320 1330 1340 1350
DIIIKAEKGT PYADILNGII IEFDSIFTCN LEGMNNLQVD SLRMCYESIF
1360 1370 1380 1390 1400
RVFEYCKKWA TEFKQNYSKL HGTFIIKDTK TTNMLLRIDE FLRTTPSDLL
1410 1420 1430 1440 1450
AQRSLETDSF ERSALYLEQC YRQNPHDKNQ NGQLLKNLQI TYEEIGDIDS
1460 1470 1480 1490 1500
LDGVLRTFAT GNLVSKIEEL QYSENWKLAQ DCFNVLGKFS DDPKTTTRML
1510 1520 1530 1540 1550
KSMYDHQLYS QIISNSSFHS SDGKISLSPD VKEWYSIGLE AANLEGNVQT
1560 1570 1580 1590 1600
LKNWVEQIES LRNIDDREVL LQYNIAKALI AISNEDPLRT QKYIHNSFRL
1610 1620 1630 1640 1650
IGTNFITSSK ETTLLKKQNL LMKLHSLYDL SFLSSAKDKF EYKSNTTILD
1660 1670 1680 1690 1700
YRMERIGADF VPNHYILSMR KSFDQLKMNE QADADLGKTF FTLAQLARNN
1710 1720 1730 1740 1750
ARLDIASESL MHCLERRLPQ AELEFAEILW KQGENDRALK IVQEIHEKYQ
1760 1770 1780 1790 1800
ENSSVNARDR AAVLLKFTEW LDLSNNSASE QIIKQYQDIF QIDSKWDKPY
1810 1820 1830 1840 1850
YSIGLYYSRL LERKKAEGYI TNGRFEYRAI SYFLLAFEKN TAKVRENLPK
1860 1870 1880 1890 1900
VITFWLDIAA ASISEAPGNR KEMLSKATED ICSHVEEALQ HCPTYIWYFV
1910 1920 1930 1940 1950
LTQLLSRLLH SHQSSAQIIM HILLSLAVEY PSHILWYITA LVNSNSSKRV
1960 1970 1980 1990 2000
LRGKHILEKY RQHSQNPHDL VSSALDLTKA LTRVCLQDVK SITSRSGKSL
2010 2020 2030 2040 2050
EKDFKFDMNV APSAMVVPVR KNLDIISPLE SNSMRGYQPF RPVVSIIRFG
2060 2070 2080 2090 2100
SSYKVFSSLK KPKQLNIIGS DGNIYGIMCK KEDVRQDNQY MQFATTMDFL
2110 2120 2130 2140 2150
LSKDIASRKR SLGINIYSVL SLREDCGILE MVPNVVTLRS ILSTKYESLK
2160 2170 2180 2190 2200
IKYSLKSLHD RWQHTAVDGK LEFYMEQVDK FPPILYQWFL ENFPDPINWF
2210 2220 2230 2240 2250
NARNTYARSY AVMAMVGHIL GLGDRHCENI LLDIQTGKVL HVDFDCLFEK
2260 2270 2280 2290 2300
GKRLPVPEIV PFRLTPNLLD ALGIIGTEGT FKKSSEVTLA LMRKNEVALM
2310 2320 2330 2340 2350
NVIETIMYDR NMDHSIQKAL KVLRNKIRGI DPQDGLVLSV AGQTETLIQE
2360
ATSEDNLSKM YIGWLPFW
Length:2,368
Mass (Da):273,342
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC06AEF9F0484A615
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti197N → D in BAA01860 (PubMed:8065923).Curated1
Sequence conflicti716S → P in AAA74482 (PubMed:7926756).Curated1
Sequence conflicti1255K → Q in AAA74482 (PubMed:7926756).Curated1
Sequence conflicti1276L → G in AAA74482 (PubMed:7926756).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X75891 Genomic DNA Translation: CAA53494.1
U31109 Genomic DNA Translation: AAA74482.1
D11088 Genomic DNA Translation: BAA01860.1
Z36005 Genomic DNA Translation: CAA85094.1
BK006936 Genomic DNA Translation: DAA07252.1

Protein sequence database of the Protein Information Resource

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PIRi
S46005

NCBI Reference Sequences

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RefSeqi
NP_009694.3, NM_001178484.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBR136W_mRNA; YBR136W; YBR136W

Database of genes from NCBI RefSeq genomes

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GeneIDi
852433

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBR136W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75891 Genomic DNA Translation: CAA53494.1
U31109 Genomic DNA Translation: AAA74482.1
D11088 Genomic DNA Translation: BAA01860.1
Z36005 Genomic DNA Translation: CAA85094.1
BK006936 Genomic DNA Translation: DAA07252.1
PIRiS46005
RefSeqiNP_009694.3, NM_001178484.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5X6Oelectron microscopy3.90C1-2368[»]
SMRiP38111
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi32836, 367 interactors
ComplexPortaliCPX-3621 ATR-ATRIP DNA damage-sensing kinase complex
DIPiDIP-799N
IntActiP38111, 23 interactors
MINTiP38111
STRINGi4932.YBR136W

PTM databases

iPTMnetiP38111

Proteomic databases

MaxQBiP38111
PaxDbiP38111
PRIDEiP38111

Genome annotation databases

EnsemblFungiiYBR136W_mRNA; YBR136W; YBR136W
GeneIDi852433
KEGGisce:YBR136W

Organism-specific databases

EuPathDBiFungiDB:YBR136W
SGDiS000000340 MEC1

Phylogenomic databases

HOGENOMiCLU_000178_4_0_1
InParanoidiP38111
KOiK02543
OMAiHLVCSCT

Enzyme and pathway databases

BioCyciYEAST:G3O-29090-MONOMER

Miscellaneous databases

Protein Ontology

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PROi
PR:P38111
RNActiP38111 protein

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR011990 TPR-like_helical_dom_sf
IPR012993 UME
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
PF08064 UME, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SM00802 UME, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATR_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38111
Secondary accession number(s): D6VQD2, Q02580
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 26, 2020
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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