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UniProtKB - P38110 (ATM_YEAST)

Entry version 174 (12 Aug 2020)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
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Protein

Serine/threonine-protein kinase TEL1

Gene

TEL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited by the MRX-complex to sites of DNA lesions immediately after damage to initiate non-homologous end-joining (NHEJ). Subsequently displaced by the RPA complex in a reaction probably involving the SAE2 protein. Phosphorylates MRE11 and XRS2, 2 subunits of the MRX-complex. The phosphorylation of MRE11 is a feedback response from the checkpoint signaling pathway. Phosphorylates RAD9, CHK1 and RAD53, leading to the activation of the CHK1 and RAD23 kinases involved in the DNA damage response cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are involved in genome stability. Required for the control of telomere length and genome stability.13 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		YEAST:G3O-28977-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-2559586, DNA Damage/Telomere Stress Induced Senescence
R-SCE-5693548, Sensing of DNA Double Strand Breaks
R-SCE-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SCE-9664873, Pexophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase TEL1 (EC:2.7.11.1)
Alternative name(s):
ATM homolog
DNA-damage checkpoint kinase TEL1
Telomere length regulation protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEL1
Ordered Locus Names:YBL088C
ORF Names:YBL0706
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:YBL088C

Saccharomyces Genome Database

More...SGDi		S000000184, TEL1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1319E → K in TEL1-11; short telomere phenotype and impairs DNA-damage checkpoint function at 37 degrees Celsius. 1 Publication1
Mutagenesisi2611 – 2612GD → DA: Short telomere phenotype in vivo and impairs kinase activity in vitro; when associated with K-2616 and E-2631. 2 Publications2
Mutagenesisi2616N → K: Short telomere phenotype in vivo and impairs kinase activity in vitro; when associated with D-2611-2612-A and E-2631. 2 Publications1
Mutagenesisi2631D → E: Short telomere phenotype in vivo and impairs kinase activity in vitro; when associated with D-2611-2612-A and K-2616. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888391 – 2787Serine/threonine-protein kinase TEL1Add BLAST2787

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P38110

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P38110

PRoteomics IDEntifications database

More...PRIDEi		P38110

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P38110

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with XRS2 and associates with DNA double-strand breaks.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		32616, 188 interactors

Database of interacting proteins

More...DIPi		DIP-6524N

Protein interaction database and analysis system

More...IntActi		P38110, 6 interactors

Molecular INTeraction database

More...MINTi		P38110

STRING: functional protein association networks

More...STRINGi		4932.YBL088C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P38110, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P38110

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1734 – 2326FATPROSITE-ProRule annotationAdd BLAST593
Domaini2461 – 2787PI3K/PI4KPROSITE-ProRule annotationAdd BLAST327
Domaini2755 – 2787FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0892, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000174195

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000178_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P38110

KEGG Orthology (KO)

More...KOi		K04728

Identification of Orthologs from Complete Genome Data

More...OMAi		YEVIPLG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015519, ATM/Tel1
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR014009, PIK_FAT
IPR021668, TAN

The PANTHER Classification System

More...PANTHERi		PTHR11139:SF72, PTHR11139:SF72, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF11640, TAN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM01342, TAN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38110-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDHGIVETL NFLSSTKIKE RNNALDELTT ILKEDPERIP TKALSTTAEA 
        60         70         80         90        100
LVELLASEHT KYCDLLRNLT VSTTNKLSLS ENRLSTISYV LRLFVEKSCE 
       110        120        130        140        150
RFKVKTLKLL LAVVPELMVK DGSKSLLDAV SVHLSFALDA LIKSDPFKLK 
       160        170        180        190        200
FMIHQWISLV DKICEYFQSQ MKLSMVDKTL TNFISILLNL LALDTVGIFQ 
       210        220        230        240        250
VTRTITWTVI DFLRLSKKEN GNTRLIMSLI NQLILKCHCF SVIDTLMLIK 
       260        270        280        290        300
EAWSYNLTIG CTSNELVQDQ LSLFDVMSSE LMNHKLPYMI GQENYVEELR 
       310        320        330        340        350
SESLVSLYRE YILLRLSNYK PQLFTVNHVE FSYIRGSRDK NSWFALPDFR 
       360        370        380        390        400
LRDRGGRSVW LKILGITKSL LTYFALNRKN ENYSLLFKRR KCDSDIPSIL 
       410        420        430        440        450
RISDDMDTFL IHLLEENSSH EFEVLGLQLC SFYGTLQDFT KSFAEQLKEL 
       460        470        480        490        500
LFSKFEKIQC FNWVCFSFIP LLSQKECELS NGDMARLFKV CLPLVKSNES 
       510        520        530        540        550
CQLSCLLLAN SIKFSKQLLS DEKTINQIYD LYELSDILGP ILVTNESFML 
       560        570        580        590        600
WGYLQYVGKD FQSMNGISSA DRIFEWLKSK WNQLRGTDAK QDQFCNFISW 
       610        620        630        640        650
LGNKYDPENP FNDKKGEGAN PVSLCWDESH KIWQHFQEQR EFLLGVKPEE 
       660        670        680        690        700
KSECFNTPFF NLPKVSLDLT RYNEILYRLL ENIESDAFSS PLQKFTWVAK 
       710        720        730        740        750
LIQIVDNLCG DSTFSEFIAA YKRTTLITIP QLSFDSQNSY QSFFEEVLSI 
       760        770        780        790        800
RTINVDHLVL DKINMKEIVN DFIRMQKNKS QTGTSAINYF EASSEDTTQN 
       810        820        830        840        850
NSPYTIGGRF QKPLHSTIDK AVRAYLWSSR NKSISERLVA ILEFSDCVST 
       860        870        880        890        900
DVFISYLGTV CQWLKQAIGE KSSYNKILEE FTEVLGEKLL CNHYSSSNQA 
       910        920        930        940        950
MLLLTSYIEA IRPQWLSYPE QPLNSDCNDI LDWIISRFED NSFTGVAPTV 
       960        970        980        990       1000
NLSMLLLSLL QNHDLSHGSI RGGKQRVFAT FIKCLQKLDS SNIINIMNSI 
      1010       1020       1030       1040       1050
SSYMAQVSYK NQSIIFYEIK SLFGPPQQSI EKSAFYSLAM SMLSLVSYPS 
      1060       1070       1080       1090       1100
LVFSLEDMMT YSGFNHTRAF IQQALNKITV AFRYQNLTEL FEYCKFDLIM 
      1110       1120       1130       1140       1150
YWFNRTKVPT SKLEKEWDIS LFGFADIHEF LGRYFVEISA IYFSQGFNQK 
      1160       1170       1180       1190       1200
WILDMLHAIT GNGDAYLVDN SYYLCIPLAF ISGGVNELIF DILPQISGKT 
      1210       1220       1230       1240       1250
TVKYHKKYRL LMLKWIIRFT DLGSLTELRS TVEKLFPTSY LSPYLFENSS 
      1260       1270       1280       1290       1300
VSMRYQYPLH IPLALGATLV QTQFAHEKNN THEFKLLFLS VITDLEKTST 
      1310       1320       1330       1340       1350
YIGKLRCARE LKYLFVLYEN VLVKSSTLNF IIIRLSKFLI DTQIHDEVIT 
      1360       1370       1380       1390       1400
IFSSLLNLAD KNTFEIEPSL PNLFCKIFIY LRENKQLSPS FQQAIKLLEH 
      1410       1420       1430       1440       1450
RDLIKIKTWK YCLDAIFGNI VQDDIYENTE LLDASDCGVD DVVLVSLLFS 
      1460       1470       1480       1490       1500
YARRPVASKI GCSLSKAAAI NILKHHVPKE YLSKNFKLWF AALSRRILQQ 
      1510       1520       1530       1540       1550
EVQRERSTNF NNEVHLKNFE MVFRHPEQPH MIYQRISTFN KEAELYDSTE 
      1560       1570       1580       1590       1600
VFFISECILT YLVGYSIGNS ESEFCFRDNI MNENKDKVAP LDKDVLNAIY 
      1610       1620       1630       1640       1650
PLANNFGMES FICDTYLSVN EPYNCWLSKF ARSLIHQISF NIPPIVCLYP 
      1660       1670       1680       1690       1700
LCKGSTAFCE LVLTDLFFLS TTYDPKSCLN WSNRIFTQIA MLLHVKDSEI 
      1710       1720       1730       1740       1750
KLKMLFNVIK MIRMGSRCKE RNCLRIYSSL DLQEICQISL KIKEFKFGYL 
      1760       1770       1780       1790       1800
LFEEMNMPNI REMNINTLQK IYECINDGDF LAGLPVPHSI EGVLNSINRI 
      1810       1820       1830       1840       1850
DSDTWKRFLF NNADFDANYT TSLEEEKESL IKATEDSGFY GLTSLLESRL 
      1860       1870       1880       1890       1900
SGSSDVYKWN LELGDWKLLT PKVVDSKAKG LYYAIKNLPQ DVGFAEKSLE 
      1910       1920       1930       1940       1950
KSLLTIFDSR QHFISQTEWM DTLNAIIEFI KIAAIPQDVT SFPQTLMSIM 
      1960       1970       1980       1990       2000
KADKERLNTI DFYDHKTTLK SRHTLMNVLS RNSLDENVKC SKYLRLGSII 
      2010       2020       2030       2040       2050
QLANYVQLAI ANGAPQDALR NATLMSKTVK NIAKLYDDPS VVSQIEKLAS 
      2060       2070       2080       2090       2100
FTSANALWES REYKAPVMIM RDLLAQNEKN ISESILYDDF KLLINVPMDQ 
      2110       2120       2130       2140       2150
IKARLVKWSS ESRLEPAAAI YEKIIVNWDI NVEDHESCSD VFYTLGSFLD 
      2160       2170       2180       2190       2200
EQAQKLRSNG EIEDREHRSY TGKSTLKALE LIYKNTKLPE NERKDAKRHY 
      2210       2220       2230       2240       2250
NRVLLQYNRD SEVLKALLLQ KEKFLWHALH FYLNTLVFSN RYDNDIIDKF 
      2260       2270       2280       2290       2300
CGLWFENDDN SKINQLLYKE IGTIPSWKFL PWVNQIASKI SMEENEFQKP 
      2310       2320       2330       2340       2350
LQLTMKRLLY KLPYDSLYSV MSILLYEKQS NKDTNISQKI QAVKKILLEL 
      2360       2370       2380       2390       2400
QGYDRGAFAK KYLLPVQEFC EMSVELANLK FVQNTKTLRL ANLKIGQYWL 
      2410       2420       2430       2440       2450
KQLNMEKLPL PTSNFTVKSS ADGRKARPYI VSVNETVGIT TTGLSLPKIV 
      2460       2470       2480       2490       2500
TFNISDGTTQ KALMKGSNDD LRQDAIMEQV FQQVNKVLQN DKVLRNLDLG 
      2510       2520       2530       2540       2550
IRTYKVVPLG PKAGIIEFVA NSTSLHQILS KLHTNDKITF DQARKGMKAV 
      2560       2570       2580       2590       2600
QTKSNEERLK AYLKITNEIK PQLRNFFFDS FPDPLDWFEA KKTYTKGVAA 
      2610       2620       2630       2640       2650
SSIVGYILGL GDRHLNNILL DCSTGEPIHI DLGIAFDQGK LLPIPELVPF 
      2660       2670       2680       2690       2700
RLTRDIVDGF GVTGVDGLFR RSCERVYAVL RKDYVKVMCV LNILKWDPLY 
      2710       2720       2730       2740       2750
SWVMSPVKKY EHLFEEEHEI TNFDNVSKFI SNNDRNENQE SYRALKGVEE 
      2760       2770       2780 
KLMGNGLSVE SSVQDLIQQA TDPSNLSVIY MGWSPFY
Length:2,787
Mass (Da):321,524
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC7FA8C6AFD6B04D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64D → E in AAA69802 (PubMed:7671310).Curated1
Sequence conflicti164C → W in CAA56016 (PubMed:7502586).Curated1
Sequence conflicti1190F → Y in CAA56016 (PubMed:7502586).Curated1
Sequence conflicti1412C → F in CAA56016 (PubMed:7502586).Curated1
Sequence conflicti1412C → F in CAA84909 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X79489 Genomic DNA Translation: CAA56016.1
Z35849 Genomic DNA Translation: CAA84909.1
U31331 Genomic DNA Translation: AAA69802.1
BK006936 Genomic DNA Translation: DAA07036.2

Protein sequence database of the Protein Information Resource

More...PIRi		S45416

NCBI Reference Sequences

More...RefSeqi		NP_009465.2, NM_001178328.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YBL088C_mRNA; YBL088C; YBL088C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		852190

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YBL088C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA Translation: CAA56016.1
Z35849 Genomic DNA Translation: CAA84909.1
U31331 Genomic DNA Translation: AAA69802.1
BK006936 Genomic DNA Translation: DAA07036.2
PIRiS45416
RefSeqiNP_009465.2, NM_001178328.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H7BX-ray1.88C/F549-557[»]
3H9HX-ray2.00C/F549-557[»]
3H9SX-ray2.70C549-557[»]
6JXAelectron microscopy4.30A1-2787[»]
6JXCelectron microscopy4.10A1-2787[»]
6S8Felectron microscopy4.00F/H968-2787[»]
SMRiP38110
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi32616, 188 interactors
DIPiDIP-6524N
IntActiP38110, 6 interactors
MINTiP38110
STRINGi4932.YBL088C

PTM databases

iPTMnetiP38110

Proteomic databases

MaxQBiP38110
PaxDbiP38110
PRIDEiP38110

Genome annotation databases

EnsemblFungiiYBL088C_mRNA; YBL088C; YBL088C
GeneIDi852190
KEGGisce:YBL088C

Organism-specific databases

EuPathDBiFungiDB:YBL088C
SGDiS000000184, TEL1

Phylogenomic databases

eggNOGiKOG0892, Eukaryota
GeneTreeiENSGT00940000174195
HOGENOMiCLU_000178_8_1_1
InParanoidiP38110
KOiK04728
OMAiYEVIPLG

Enzyme and pathway databases

BioCyciYEAST:G3O-28977-MONOMER
ReactomeiR-SCE-2559586, DNA Damage/Telomere Stress Induced Senescence
R-SCE-5693548, Sensing of DNA Double Strand Breaks
R-SCE-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-SCE-9664873, Pexophagy

Miscellaneous databases

Protein Ontology

More...PROi		PR:P38110
RNActiP38110, protein

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR015519, ATM/Tel1
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR014009, PIK_FAT
IPR021668, TAN
PANTHERiPTHR11139:SF72, PTHR11139:SF72, 1 hit
PfamiView protein in Pfam
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF11640, TAN, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM01342, TAN, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATM_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38110
Secondary accession number(s): D6VPR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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