UniProtKB - P38104 (RSPA_ECOLI)
Protein
Starvation-sensing protein RspA
Gene
rspA
Organism
Escherichia coli (strain K12)
Status
Functioni
Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation.
Miscellaneous
Overexpression prevents homoserine lactone-dependent synthesis of the sigma S factor (rpoS).1 Publication
GO - Biological processi
- cellular amino acid catabolic process Source: InterPro
Enzyme and pathway databases
BioCyci | EcoCyc:G6839-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Starvation-sensing protein RspA |
Gene namesi | Name:rspA1 Publication Ordered Locus Names:b1581, JW1573 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171260 | 1 – 404 | Starvation-sensing protein RspAAdd BLAST | 404 |
Proteomic databases
PaxDbi | P38104 |
PRIDEi | P38104 |
Expressioni
Inductioni
Repressed by RspR.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260233, 6 interactors |
DIPi | DIP-10805N |
IntActi | P38104, 14 interactors |
STRINGi | 511145.b1581 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mandelate racemase/muconate lactonizing enzyme family.Curated
Phylogenomic databases
eggNOGi | COG4948, Bacteria |
HOGENOMi | CLU_030273_6_1_6 |
InParanoidi | P38104 |
PhylomeDBi | P38104 |
Family and domain databases
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
InterProi | View protein in InterPro IPR034589, D-mannonate_dehydratase-like IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR029065, Enolase_C-like IPR018110, Mandel_Rmase/mucon_lact_enz_CS IPR034593, Mandelate_racemase-like IPR013342, Mandelate_racemase_C IPR013341, Mandelate_racemase_N_dom |
PANTHERi | PTHR43287, PTHR43287, 1 hit PTHR43287:SF3, PTHR43287:SF3, 1 hit |
Pfami | View protein in Pfam PF13378, MR_MLE_C, 1 hit PF02746, MR_MLE_N, 1 hit |
SFLDi | SFLDG00033, mannonate_dehydratase, 1 hit |
SMARTi | View protein in SMART SM00922, MR_MLE, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
PROSITEi | View protein in PROSITE PS00908, MR_MLE_1, 1 hit PS00909, MR_MLE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P38104-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIVKAEVFV TCPGRNFVTL KITTEDGITG LGDATLNGRE LSVASYLQDH
60 70 80 90 100
LCPQLIGRDA HRIEDIWQFF YKGAYWRRGP VTMSAISAVD MALWDIKAKA
110 120 130 140 150
ANMPLYQLLG GASREGVMVY CHTTGHSIDE ALDDYARHQE LGFKAIRVQC
160 170 180 190 200
GIPGMKTTYG MSKGKGLAYE PATKGQWPEE QLWSTEKYLD FMPKLFDAVR
210 220 230 240 250
NKFGFNEHLL HDMHHRLTPI EAARFGKSIE DYRMFWMEDP TPAENQECFR
260 270 280 290 300
LIRQHTVTPI AVGEVFNSIW DCKQLIEEQL IDYIRTTLTH AGGITGMRRI
310 320 330 340 350
ADFASLYQVR TGSHGPSDLS PVCMAAALHF DLWVPNFGVQ EYMGYSEQML
360 370 380 390 400
EVFPHNWTFD NGYMHPGDKP GLGIEFDEKL AAKYPYEPAY LPVARLEDGT
LWNW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31628 Genomic DNA Translation: AAA21685.1 U00096 Genomic DNA Translation: AAC74653.1 AP009048 Genomic DNA Translation: BAA15285.1 |
PIRi | I59589 |
RefSeqi | NP_416098.1, NC_000913.3 WP_001295394.1, NZ_STEB01000003.1 |
Genome annotation databases
EnsemblBacteriai | AAC74653; AAC74653; b1581 BAA15285; BAA15285; BAA15285 |
GeneIDi | 946126 |
KEGGi | ecj:JW1573 eco:b1581 |
PATRICi | fig|1411691.4.peg.681 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L31628 Genomic DNA Translation: AAA21685.1 U00096 Genomic DNA Translation: AAC74653.1 AP009048 Genomic DNA Translation: BAA15285.1 |
PIRi | I59589 |
RefSeqi | NP_416098.1, NC_000913.3 WP_001295394.1, NZ_STEB01000003.1 |
3D structure databases
SMRi | P38104 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260233, 6 interactors |
DIPi | DIP-10805N |
IntActi | P38104, 14 interactors |
STRINGi | 511145.b1581 |
Proteomic databases
PaxDbi | P38104 |
PRIDEi | P38104 |
Genome annotation databases
EnsemblBacteriai | AAC74653; AAC74653; b1581 BAA15285; BAA15285; BAA15285 |
GeneIDi | 946126 |
KEGGi | ecj:JW1573 eco:b1581 |
PATRICi | fig|1411691.4.peg.681 |
Organism-specific databases
EchoBASEi | EB2345 |
Phylogenomic databases
eggNOGi | COG4948, Bacteria |
HOGENOMi | CLU_030273_6_1_6 |
InParanoidi | P38104 |
PhylomeDBi | P38104 |
Enzyme and pathway databases
BioCyci | EcoCyc:G6839-MONOMER |
Miscellaneous databases
PROi | PR:P38104 |
Family and domain databases
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
InterProi | View protein in InterPro IPR034589, D-mannonate_dehydratase-like IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR029065, Enolase_C-like IPR018110, Mandel_Rmase/mucon_lact_enz_CS IPR034593, Mandelate_racemase-like IPR013342, Mandelate_racemase_C IPR013341, Mandelate_racemase_N_dom |
PANTHERi | PTHR43287, PTHR43287, 1 hit PTHR43287:SF3, PTHR43287:SF3, 1 hit |
Pfami | View protein in Pfam PF13378, MR_MLE_C, 1 hit PF02746, MR_MLE_N, 1 hit |
SFLDi | SFLDG00033, mannonate_dehydratase, 1 hit |
SMARTi | View protein in SMART SM00922, MR_MLE, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
PROSITEi | View protein in PROSITE PS00908, MR_MLE_1, 1 hit PS00909, MR_MLE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSPA_ECOLI | |
Accessioni | P38104Primary (citable) accession number: P38104 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families