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Entry version 157 (08 May 2019)
Sequence version 2 (01 Nov 1997)
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Protein

Probable diguanylate cyclase DgcE

Gene

dgcE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of c-di-GMP (Probable). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD (PubMed:23708798).By similarity1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per monomer.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 3',5'-cyclic di-GMP biosynthesis

This protein is involved in the pathway 3',5'-cyclic di-GMP biosynthesis, which is part of Purine metabolism.Curated
View all proteins of this organism that are known to be involved in the pathway 3',5'-cyclic di-GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi720MagnesiumBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei725Transition state stabilizerSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei728SubstrateBy similarity1
Binding sitei733Substrate; via carbonyl oxygenBy similarity1
Binding sitei737SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei763Proton acceptorSequence analysis1
Metal bindingi763MagnesiumBy similarity1
Binding sitei783SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG12396-MONOMER
ECOL316407:JW2052-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00599

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable diguanylate cyclase DgcECurated (EC:2.7.7.65By similarity)
Short name:
DGCCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dgcE1 Publication
Synonyms:yegE
Ordered Locus Names:b2067, JW2052
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG12396 yegE

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei190 – 207HelicalSequence analysisAdd BLAST18
Transmembranei211 – 228HelicalSequence analysisAdd BLAST18
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Decreased biofilm formation, decreased expression of DgcC, a probable diguanylate cyclase and of the curli regulator CsgD (PubMed:19332833). Disruption leads to decreaseded expression of adhesive curli fimbriae genes (PubMed:18765794). Also partially suppresses the reduced motility of a pdeH disruption; concomitant disruption of dosC, dgcE, dgcQ and dgcN completely restores motility, suggesting these 4 genes, together with the c-di-GMP phosphodiesterase PdeH, form a network that regulates cell motility by altering levels of c-di-GMP.3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001691221 – 1105Probable diguanylate cyclase DgcEAdd BLAST1105

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P38097

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P38097

PRoteomics IDEntifications database

More...
PRIDEi
P38097

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expressed during transition into stationary phase, expression is equal at 28 and 37 degrees Celsius. Expression is RpoS dependent.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4259682, 200 interactors

Protein interaction database and analysis system

More...
IntActi
P38097, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b2067

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P38097

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 370PAS 1PROSITE-ProRule annotationAdd BLAST71
Domaini374 – 426PAC 1PROSITE-ProRule annotationAdd BLAST53
Domaini501 – 552PAC 2PROSITE-ProRule annotationAdd BLAST52
Domaini553 – 623PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini626 – 680PAC 3PROSITE-ProRule annotationAdd BLAST55
Domaini712 – 845GGDEFPROSITE-ProRule annotationAdd BLAST134
Domaini855 – 1104EALPROSITE-ProRule annotationAdd BLAST250

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105BZU Bacteria
COG2202 LUCA
COG3447 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000122009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P38097

KEGG Orthology (KO)

More...
KOi
K21084

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P38097

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01949 GGDEF, 1 hit
cd00130 PAS, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.450, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001633 EAL_dom
IPR035919 EAL_sf
IPR000160 GGDEF_dom
IPR007895 MASE1
IPR029787 Nucleotide_cyclase
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR013656 PAS_4
IPR013655 PAS_fold_3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00563 EAL, 1 hit
PF00990 GGDEF, 1 hit
PF05231 MASE1, 1 hit
PF08447 PAS_3, 1 hit
PF08448 PAS_4, 1 hit
PF13426 PAS_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00052 EAL, 1 hit
SM00267 GGDEF, 1 hit
SM00086 PAC, 3 hits
SM00091 PAS, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141868 SSF141868, 1 hit
SSF55073 SSF55073, 1 hit
SSF55785 SSF55785, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00254 GGDEF, 1 hit
TIGR00229 sensory_box, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50883 EAL, 1 hit
PS50887 GGDEF, 1 hit
PS50113 PAC, 3 hits
PS50112 PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P38097-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKQSQHVLI ALPHPLLHLV SLGLVSFIFT LFSLELSQFG TQLAPLWFPT
60 70 80 90 100
SIMMVAFYRH AGRMWPGIAL SCSLGNIAAS ILLFSTSSLN MTWTTINIVE
110 120 130 140 150
AVVGAVLLRK LLPWYNPLQN LADWLRLALG SAIVPPLLGG VLVVLLTPGD
160 170 180 190 200
DPLRAFLIWV LSESIGALAL VPLGLLFKPH YLLRHRNPRL LFESLLTLAI
210 220 230 240 250
TLTLSWLSML YLPWPFTFII VLLMWSAVRL PRMEAFLIFL TTVMMVSLMM
260 270 280 290 300
AADPSLLATP RTYLMSHMPW LPFLLILLPA NIMTMVMYAF RAERKHISES
310 320 330 340 350
ETHFRNAMEY SAIGMALVGT EGQWLQTNKA LCQFLGYSQE ELRGLTFQQL
360 370 380 390 400
TWPEDLNKDL QQVEKLISGE INTYSMEKRY YNRNGDVVWA LLAVSLVRHT
410 420 430 440 450
DGTPLYFIAQ IEDINELKRT EQVNQQLMER ITLANEAGGI GIWEWELKPN
460 470 480 490 500
IFSWDKRMFE LYEIPPHIKP NWQVWYECVL PEDRQHAEKV IRDSLQSRSP
510 520 530 540 550
FKLEFRITVK DGIRHIRALA NRVLNKEGEV ERLLGINMDM TEVKQLNEAL
560 570 580 590 600
FQEKERLHIT LDSIGEAVVC IDMAMKITFM NPVAEKMSGW TQEEALGVPL
610 620 630 640 650
LTVLHITFGD NGPLMENIYS ADTSRSAIEQ DVVLHCRSGG SYDVHYSITP
660 670 680 690 700
LSTLDGSNIG SVLVIQDVTE SRKMLRQLSY SASHDALTHL ANRASFEKQL
710 720 730 740 750
RILLQTVNST HQRHALVFID LDRFKAVNDS AGHAAGDALL RELASLMLSM
760 770 780 790 800
LRSSDVLARL GGDEFGLLLP DCNVESARFI ATRIISAVND YHFIWEGRVH
810 820 830 840 850
RVGASAGITL IDDNNHQAAE VMSQADIACY ASKNGGRGRV TVYEPQQAAA
860 870 880 890 900
HSERAAMSLD EQWRMIKENQ LMMLAHGVAS PRIPEARNLW LISLKLWSCE
910 920 930 940 950
GEIIDEQTFR RSFSDPALSH ALDRRVFHEF FQQAAKAVAS KGISISLPLS
960 970 980 990 1000
VAGLSSATLV NDLLEQLENS PLPPRLLHLI IPAEAILDHA ESVQKLRLAG
1010 1020 1030 1040 1050
CRIVLSQVGR DLQIFNSLKA NMADYLLLDG ELCANVQGNL MDEMLITIIQ
1060 1070 1080 1090 1100
GHAQRLGMKT IAGPVVLPLV MDTLSGIGVD LIYGEVIADA QPLDLLVNSS

YFAIN
Length:1,105
Mass (Da):123,887
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22BE64B963CB9739
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti965 – 966EQ → NS in K02498 (PubMed:6094528).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75128.1
AP009048 Genomic DNA Translation: BAA15920.1
K02498 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
B64973

NCBI Reference Sequences

More...
RefSeqi
NP_416571.1, NC_000913.3
WP_000043761.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75128; AAC75128; b2067
BAA15920; BAA15920; BAA15920

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946600

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2052
eco:b2067

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.184

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75128.1
AP009048 Genomic DNA Translation: BAA15920.1
K02498 Genomic DNA No translation available.
PIRiB64973
RefSeqiNP_416571.1, NC_000913.3
WP_000043761.1, NZ_LN832404.1

3D structure databases

SMRiP38097
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4259682, 200 interactors
IntActiP38097, 1 interactor
STRINGi511145.b2067

Proteomic databases

jPOSTiP38097
PaxDbiP38097
PRIDEiP38097

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75128; AAC75128; b2067
BAA15920; BAA15920; BAA15920
GeneIDi946600
KEGGiecj:JW2052
eco:b2067
PATRICifig|1411691.4.peg.184

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2297
EcoGeneiEG12396 yegE

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
COG2202 LUCA
COG3447 LUCA
HOGENOMiHOG000122009
InParanoidiP38097
KOiK21084
PhylomeDBiP38097

Enzyme and pathway databases

UniPathwayiUPA00599
BioCyciEcoCyc:EG12396-MONOMER
ECOL316407:JW2052-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P38097

Family and domain databases

CDDicd01949 GGDEF, 1 hit
cd00130 PAS, 3 hits
Gene3Di3.20.20.450, 1 hit
InterProiView protein in InterPro
IPR001633 EAL_dom
IPR035919 EAL_sf
IPR000160 GGDEF_dom
IPR007895 MASE1
IPR029787 Nucleotide_cyclase
IPR001610 PAC
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR013656 PAS_4
IPR013655 PAS_fold_3
PfamiView protein in Pfam
PF00563 EAL, 1 hit
PF00990 GGDEF, 1 hit
PF05231 MASE1, 1 hit
PF08447 PAS_3, 1 hit
PF08448 PAS_4, 1 hit
PF13426 PAS_9, 1 hit
SMARTiView protein in SMART
SM00052 EAL, 1 hit
SM00267 GGDEF, 1 hit
SM00086 PAC, 3 hits
SM00091 PAS, 3 hits
SUPFAMiSSF141868 SSF141868, 1 hit
SSF55073 SSF55073, 1 hit
SSF55785 SSF55785, 3 hits
TIGRFAMsiTIGR00254 GGDEF, 1 hit
TIGR00229 sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50883 EAL, 1 hit
PS50887 GGDEF, 1 hit
PS50113 PAC, 3 hits
PS50112 PAS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDGCE_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P38097
Secondary accession number(s): P76391
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: May 8, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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