UniProtKB - P38090 (AGP2_YEAST)
Protein
General amino acid permease AGP2
Gene
AGP2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
General amino acid permease with broad substrate specificity. Can also transport carnitine.2 Publications
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
- positive regulation of (R)-carnitine transmembrane transport Source: SGD
- positive regulation of polyamine transmembrane transport Source: SGD
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
SABIO-RKi | P38090 |
Protein family/group databases
TCDBi | 2.A.3.10.19, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: General amino acid permease AGP2 |
Gene namesi | Name:AGP2 Ordered Locus Names:YBR132C ORF Names:YBR1007 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YBR132C |
SGDi | S000000336, AGP2 |
Subcellular locationi
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
- endoplasmic reticulum membrane Source: SGD
Plasma Membrane
- integral component of plasma membrane Source: SGD
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 94 | CytoplasmicSequence analysisAdd BLAST | 94 | |
Transmembranei | 95 – 115 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 116 – 117 | ExtracellularSequence analysis | 2 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 165 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 199 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 221 – 227 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 228 – 248 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 249 – 288 | ExtracellularSequence analysisAdd BLAST | 40 | |
Transmembranei | 289 – 309 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 310 – 326 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 348 – 379 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 380 – 400 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 401 – 427 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 428 – 448 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 449 – 459 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 460 – 480 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 481 – 505 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 506 – 526 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 527 – 534 | ExtracellularSequence analysis | 8 | |
Transmembranei | 535 – 555 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 556 – 596 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054143 | 1 – 596 | General amino acid permease AGP2Add BLAST | 596 |
Proteomic databases
MaxQBi | P38090 |
PaxDbi | P38090 |
PRIDEi | P38090 |
PTM databases
iPTMneti | P38090 |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 32833, 117 interactors |
DIPi | DIP-8141N |
IntActi | P38090, 8 interactors |
MINTi | P38090 |
STRINGi | 4932.YBR132C |
Miscellaneous databases
RNActi | P38090, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
HOGENOMi | CLU_007946_12_1_1 |
InParanoidi | P38090 |
OMAi | NFWFLEC |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P38090-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN
60 70 80 90 100
TIPEAGDVHV DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG
110 120 130 140 150
VIGTALFVAI GKALYRGGPA SLLLAFALWC VPILCITVST AEMVCFFPVS
160 170 180 190 200
SPFLRLATKC VDDSLAVMAS WNFWFLECVQ IPFEIVSVNT IIHYWRDDYS
210 220 230 240 250
AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG LFTFTFITML
260 270 280 290 300
GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI
310 320 330 340 350
AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND
360 370 380 390 400
PDLTAAINEA RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY
410 420 430 440 450
TYCSSRTFYG MALDGYAPKI FTRCNRHGVP IYSVAISLVW ALVSLLQLNS
460 470 480 490 500
NSAVVLNWLI NLITASQLIN FVVLCIVYLF FRRAYHVQQD SLPKLPFRSW
510 520 530 540 550
GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL MVFINIGIYV
560 570 580 590
GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75891 Genomic DNA Translation: CAA53491.1 Z36001 Genomic DNA Translation: CAA85089.1 BK006936 Genomic DNA Translation: DAA07249.1 |
PIRi | S46001 |
RefSeqi | NP_009690.1, NM_001178480.1 |
Genome annotation databases
EnsemblFungii | YBR132C_mRNA; YBR132C; YBR132C |
GeneIDi | 852429 |
KEGGi | sce:YBR132C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75891 Genomic DNA Translation: CAA53491.1 Z36001 Genomic DNA Translation: CAA85089.1 BK006936 Genomic DNA Translation: DAA07249.1 |
PIRi | S46001 |
RefSeqi | NP_009690.1, NM_001178480.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 32833, 117 interactors |
DIPi | DIP-8141N |
IntActi | P38090, 8 interactors |
MINTi | P38090 |
STRINGi | 4932.YBR132C |
Protein family/group databases
TCDBi | 2.A.3.10.19, the amino acid-polyamine-organocation (apc) family |
PTM databases
iPTMneti | P38090 |
Proteomic databases
MaxQBi | P38090 |
PaxDbi | P38090 |
PRIDEi | P38090 |
Genome annotation databases
EnsemblFungii | YBR132C_mRNA; YBR132C; YBR132C |
GeneIDi | 852429 |
KEGGi | sce:YBR132C |
Organism-specific databases
EuPathDBi | FungiDB:YBR132C |
SGDi | S000000336, AGP2 |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
HOGENOMi | CLU_007946_12_1_1 |
InParanoidi | P38090 |
OMAi | NFWFLEC |
Enzyme and pathway databases
SABIO-RKi | P38090 |
Miscellaneous databases
PROi | PR:P38090 |
RNActi | P38090, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGP2_YEAST | |
Accessioni | P38090Primary (citable) accession number: P38090 Secondary accession number(s): D6VQC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names