UniProtKB - P38089 (PP2C4_YEAST)
Protein
Protein phosphatase 2C homolog 4
Gene
PTC4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 149 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Cofactori
Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 83 | Manganese 1By similarity | 1 | |
Metal bindingi | 83 | Manganese 2By similarity | 1 | |
Metal bindingi | 84 | Manganese 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 310 | Manganese 2By similarity | 1 | |
Metal bindingi | 359 | Manganese 2By similarity | 1 |
GO - Molecular functioni
- magnesium-dependent protein serine/threonine phosphatase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- protein serine/threonine phosphatase activity Source: SGD
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- protein dephosphorylation Source: SGD
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Ligand | Magnesium, Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29081-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PTC4 Synonyms:GCT1 Ordered Locus Names:YBR125C ORF Names:YBR0921 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000329, PTC4 |
VEuPathDBi | FungiDB:YBR125C |
Subcellular locationi
Other locations
- cytoplasm Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057777 | 1 – 393 | Protein phosphatase 2C homolog 4Add BLAST | 393 |
Proteomic databases
MaxQBi | P38089 |
PaxDbi | P38089 |
PRIDEi | P38089 |
PTM databases
iPTMneti | P38089 |
Interactioni
Binary interactionsi
P38089
With | #Exp. | IntAct |
---|---|---|
PAA1 [Q12447] | 5 | EBI-12814,EBI-33397 |
Protein-protein interaction databases
BioGRIDi | 32826, 209 interactors |
DIPi | DIP-6437N |
IntActi | P38089, 11 interactors |
MINTi | P38089 |
STRINGi | 4932.YBR125C |
Miscellaneous databases
RNActi | P38089, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 368 | PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST | 336 |
Sequence similaritiesi
Belongs to the PP2C family.Curated
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
HOGENOMi | CLU_013173_4_2_1 |
InParanoidi | P38089 |
OMAi | AKFAGKH |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR000222, PP2C_BS IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS01032, PPM_1, 1 hit PS51746, PPM_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P38089-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQLLSHPLT EKTIEYNEYK NNQASTGIVP RFYNCVGSMQ GYRLTQEDAH
60 70 80 90 100
LIRNENSVVY VRFFNPFIDK YETLSLNVFA VFDGHGGDDC SKFLSGGRHH
110 120 130 140 150
RDGNGSSNGN GEPNAGLIKW IAYSFENHHY TSTTNNDSSK FKRSFNTLEG
160 170 180 190 200
LVSQIFKDAF ILQDEELYRH FANSSCGSTA VVACIINEES LYVANCGDSR
210 220 230 240 250
CILSSKSNGI KTMSFDHKPQ HIGELIRIND NGGTVSLGRV GGVLALSRAF
260 270 280 290 300
SDFQFKRGVT YPHRRTKLTN ITQNLTYGTP PQEAQVTVEP DVLMHKIDYS
310 320 330 340 350
KDEFLVLACD GIWDIYNNKQ LIHFIKYHLV SGTKLDTIIT KLLDHGIAQA
360 370 380 390
NSNTGVGFDN MTAIIVVLNR KGETLQDWFN KMKTRLERER GLV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78993 Genomic DNA Translation: CAA55626.1 Z35994 Genomic DNA Translation: CAA85082.1 BK006936 Genomic DNA Translation: DAA07242.1 |
PIRi | S48288 |
RefSeqi | NP_009683.1, NM_001178473.1 |
Genome annotation databases
EnsemblFungii | YBR125C_mRNA; YBR125C; YBR125C |
GeneIDi | 852422 |
KEGGi | sce:YBR125C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78993 Genomic DNA Translation: CAA55626.1 Z35994 Genomic DNA Translation: CAA85082.1 BK006936 Genomic DNA Translation: DAA07242.1 |
PIRi | S48288 |
RefSeqi | NP_009683.1, NM_001178473.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 32826, 209 interactors |
DIPi | DIP-6437N |
IntActi | P38089, 11 interactors |
MINTi | P38089 |
STRINGi | 4932.YBR125C |
PTM databases
iPTMneti | P38089 |
Proteomic databases
MaxQBi | P38089 |
PaxDbi | P38089 |
PRIDEi | P38089 |
Genome annotation databases
EnsemblFungii | YBR125C_mRNA; YBR125C; YBR125C |
GeneIDi | 852422 |
KEGGi | sce:YBR125C |
Organism-specific databases
SGDi | S000000329, PTC4 |
VEuPathDBi | FungiDB:YBR125C |
Phylogenomic databases
eggNOGi | KOG0698, Eukaryota |
HOGENOMi | CLU_013173_4_2_1 |
InParanoidi | P38089 |
OMAi | AKFAGKH |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29081-MONOMER |
Miscellaneous databases
PROi | PR:P38089 |
RNActi | P38089, protein |
Family and domain databases
CDDi | cd00143, PP2Cc, 1 hit |
Gene3Di | 3.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015655, PP2C IPR000222, PP2C_BS IPR036457, PPM-type_dom_sf IPR001932, PPM-type_phosphatase_dom |
PANTHERi | PTHR13832, PTHR13832, 1 hit |
Pfami | View protein in Pfam PF00481, PP2C, 1 hit |
SMARTi | View protein in SMART SM00332, PP2Cc, 1 hit |
SUPFAMi | SSF81606, SSF81606, 1 hit |
PROSITEi | View protein in PROSITE PS01032, PPM_1, 1 hit PS51746, PPM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP2C4_YEAST | |
Accessioni | P38089Primary (citable) accession number: P38089 Secondary accession number(s): D6VQC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - SIMILARITY comments
Index of protein domains and families