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UniProtKB - P38084 (BAP2_YEAST)
Protein
Leu/Val/Ile amino-acid permease
Gene
BAP2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan.
2 PublicationsMiscellaneous
Present with 8660 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: SGD
- L-phenylalanine transmembrane transporter activity Source: CACAO
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
- amino acid transport Source: SGD
- leucine import across plasma membrane Source: CACAO
- transmembrane transport Source: SGD
Keywordsi
Biological process | Amino-acid transport, Transport |
Protein family/group databases
TCDBi | 2.A.3.10.6, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Leu/Val/Ile amino-acid permeaseAlternative name(s): Branched-chain amino-acid permease 2 |
Gene namesi | Name:BAP2 Ordered Locus Names:YBR068C ORF Names:YBR0629 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000272, BAP2 |
VEuPathDBi | FungiDB:YBR068C |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Plasma Membrane
- plasma membrane Source: SGD
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 99 | CytoplasmicSequence analysisAdd BLAST | 99 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 123 | ExtracellularSequence analysis | 3 | |
Transmembranei | 124 – 144 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 145 – 173 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 174 – 194 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 195 – 210 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 211 – 231 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 235 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 289 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 290 – 310 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 311 – 328 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 329 – 349 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 350 – 374 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 375 – 395 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 396 – 427 | CytoplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 428 – 448 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 449 – 451 | ExtracellularSequence analysis | 3 | |
Transmembranei | 452 – 472 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 473 – 500 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 501 – 521 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 522 – 536 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 537 – 557 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 558 – 609 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054146 | 1 – 609 | Leu/Val/Ile amino-acid permeaseAdd BLAST | 609 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Modified residuei | 15 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 19 | PhosphoserineCombined sources | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Modified residuei | 76 | PhosphoserineCombined sources | 1 | |
Modified residuei | 84 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P38084 |
PaxDbi | P38084 |
PRIDEi | P38084 |
PTM databases
iPTMneti | P38084 |
SwissPalmi | P38084 |
Interactioni
Binary interactionsi
P38084
With | #Exp. | IntAct |
---|---|---|
SHR3 [Q02774] | 3 | EBI-3414,EBI-17099 |
Protein-protein interaction databases
BioGRIDi | 32771, 101 interactors |
DIPi | DIP-4910N |
IntActi | P38084, 14 interactors |
MINTi | P38084 |
STRINGi | 4932.YBR068C |
Miscellaneous databases
RNActi | P38084, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 48 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 41 | Polar residuesSequence analysisAdd BLAST | 41 |
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000176401 |
HOGENOMi | CLU_007946_12_0_1 |
InParanoidi | P38084 |
OMAi | PKFLDYV |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P38084-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSSEDFGSS GKKETSPDSI SIRSFSAGNN FQSSSSEKTY SKQKSGSDKL
60 70 80 90 100
IHRFADSFKR AEGSTTRTKQ INENTSDLED GVESITSDSK LKKSMKSRHV
110 120 130 140 150
VMMSLGTGIG TGLLVANAKG LHYGGPAALI IGYILVSFVT YFMIQAAGEM
160 170 180 190 200
AVTYPTLPAN FNAYSSIFIS KSFGFATVWL YCFQWLTVLP LELITASMTI
210 220 230 240 250
QFWNDKINPD IYILIFYVFL VFIHFFGVKA YGETEFIFNC CKILMIAGFI
260 270 280 290 300
ILSIVINCGG AGNDGYIGAT YWHNPGAFAG DTSIGRFKNV CYILVTAYFS
310 320 330 340 350
FGGMELFALS VQEQSNPRKS TPVAAKRSIY RIVVIYLLTM ILIGFNVPYN
360 370 380 390 400
DDQLMGAGGS ATHASPYVLA ASIHGVKIVP HIINAVILIS VVSVANSSLY
410 420 430 440 450
AGPRLICSLA QQGYAPKFLD YVDREGRPLR ALIVCCVFGV IAFVAASSKE
460 470 480 490 500
EIVFTWLAAI AGLSELFTWT SIMLSHLRFR QAMKVQGRSL DELGYKATTG
510 520 530 540 550
IWGSIYGVFF NILVFVAQFW VALAPLGNGG KCDAESFFQN YLAFPIWLAF
560 570 580 590 600
YFGYMVYNRD FTLLNPLDKI DLDFHRRIYD PELMRQEDEE NKEKLRNMSL
MRKAYHFWC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | V → E in CAA85012 (PubMed:7813418).Curated | 1 | |
Sequence conflicti | 203 | W → G in CAA85012 (PubMed:7813418).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z35937 Genomic DNA Translation: CAA85012.1 BK006936 Genomic DNA Translation: DAA07187.2 |
PIRi | S45930 |
RefSeqi | NP_009624.4, NM_001178416.4 |
Genome annotation databases
EnsemblFungii | YBR068C_mRNA; YBR068C; YBR068C |
GeneIDi | 852360 |
KEGGi | sce:YBR068C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z35937 Genomic DNA Translation: CAA85012.1 BK006936 Genomic DNA Translation: DAA07187.2 |
PIRi | S45930 |
RefSeqi | NP_009624.4, NM_001178416.4 |
3D structure databases
SMRi | P38084 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32771, 101 interactors |
DIPi | DIP-4910N |
IntActi | P38084, 14 interactors |
MINTi | P38084 |
STRINGi | 4932.YBR068C |
Protein family/group databases
TCDBi | 2.A.3.10.6, the amino acid-polyamine-organocation (apc) family |
PTM databases
iPTMneti | P38084 |
SwissPalmi | P38084 |
Proteomic databases
MaxQBi | P38084 |
PaxDbi | P38084 |
PRIDEi | P38084 |
Genome annotation databases
EnsemblFungii | YBR068C_mRNA; YBR068C; YBR068C |
GeneIDi | 852360 |
KEGGi | sce:YBR068C |
Organism-specific databases
SGDi | S000000272, BAP2 |
VEuPathDBi | FungiDB:YBR068C |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000176401 |
HOGENOMi | CLU_007946_12_0_1 |
InParanoidi | P38084 |
OMAi | PKFLDYV |
Miscellaneous databases
PROi | PR:P38084 |
RNActi | P38084, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BAP2_YEAST | |
Accessioni | P38084Primary (citable) accession number: P38084 Secondary accession number(s): D6VQ67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - SIMILARITY comments
Index of protein domains and families