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Protein

AP-2 complex subunit alpha

Gene

APL3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor. Facilitates interaction between APL1 and APS2.1 Publication

Miscellaneous

Present with 1590 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • clathrin-dependent endocytosis Source: InterPro
  • intracellular protein transport Source: SGD

Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28939-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SCE-8866427 VLDLR internalisation and degradation
R-SCE-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit alpha
Alternative name(s):
Alpha-adaptin
Clathrin assembly protein complex 2 alpha large chain
Clathrin assembly protein large alpha chain
Gene namesi
Name:APL3
Ordered Locus Names:YBL037W
ORF Names:YBL0412
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL037W
SGDiS000000133 APL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937371 – 1025AP-2 complex subunit alphaAdd BLAST1025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei727PhosphothreonineCombined sources1
Modified residuei733PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38065
PaxDbiP38065
PRIDEiP38065

PTM databases

iPTMnetiP38065

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32660, 81 interactors
ComplexPortaliCPX-534 Adapter complex AP-2
DIPiDIP-2634N
IntActiP38065, 42 interactors
MINTiP38065
STRINGi4932.YBL037W

Structurei

3D structure databases

ProteinModelPortaliP38065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074757
HOGENOMiHOG000033976
InParanoidiP38065
KOiK11824
OMAiHNELFNC
OrthoDBiEOG092C0BGI

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR017104 AP2_complex_asu
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PIRSFiPIRSF037091 AP2_complex_alpha, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequencei

Sequence statusi: Complete.

P38065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRKKTLINS SVSNNNSTIK GLQLFIADLR SAQQAQEQEK RIQSEIVKIK
60 70 80 90 100
QHFDAAKKKQ GNHDRLGGYQ RKKYVAKLAY IYITSNTTKL NEILFGLEQT
110 120 130 140 150
VELLKSSIFS EKFIGYMTLE LLYERSEVVA KVNDEVNYQL MKDLSSSDDN
160 170 180 190 200
FVMLALNFVG VVGELTNRLA YNDDITTGVF KILRSPTSSI YLKKKSALSF
210 220 230 240 250
LALLKSNHSI LTEDLQRKQL WIQRILSLLD DTENYRLTLA TIPLIEFIAK
260 270 280 290 300
YIDPSYCTRL LPQLTEILYN CVVVGTSRSS DNQFPLEYTF ANMPNPWLIT
310 320 330 340 350
KVVSLLSILI ASPTERDSGS LLQTNNIDNE LLNKLRKCVS VAIELGTRQA
360 370 380 390 400
QDPMERIVQN TVLFSLINFA SKLDPSDEAI SNSVTALCSL LTSKEINIRY
410 420 430 440 450
LTLDSLVKLC SSSGKPAIDA VRYKNLDMIF HLLNTERDSS IVRKVVDLLY
460 470 480 490 500
TFTDVENVKI IVDGLLQYIL SPKNLAEPQI KSDIAVKIAI LTEKYATDIN
510 520 530 540 550
WFVIISLQLL SLTSNTTIND DEIWQRLCQI VVNNPSLHRI TCERLVDYLC
560 570 580 590 600
KKQASEAIIK AAAFLLGEYS SLITDRISSA NLFTLFAEKY FSAPNVAKAM
610 620 630 640 650
ILTTMIKLYK TSPEIGSNVI KFFQLELNSL DIELQTRSFE YLNIIQLAKV
660 670 680 690 700
NGNTDILQIL FEPMPPFNSK SNPLLKRLGS LPASAGSTTL INTPSEASSS
710 720 730 740 750
TPDLLSKRAN SSRSIMVPMP PPSRRNTIDD VNSKISSSED FSGKDSYYSR
760 770 780 790 800
QILAPNWREG FTRMISHKQG VLFTSSLMKV FYRITTPDAQ QPYVFHISLA
810 820 830 840 850
FINLTEWEIT GLSTQIIPSK TQGNPEYLIM NINTPSTATI GPHKRAEQSY
860 870 880 890 900
EVSIRKPFDV EDSPILAIHF KCGGSTNTIN LKTAIGMTTT LISSDVNPSM
910 920 930 940 950
HLNLAQFISR WKTLSDALGK EGEYQKSGIK LNKDFRKVET ISLEDGLLLL
960 970 980 990 1000
TQTVKRLGFD IVDQTSVRST LFVSGIIHTK SEGNFGCLMK IQYQVNGTVN
1010 1020
VTCKTTTAGP LAKYIVECIK NVLTK
Length:1,025
Mass (Da):115,012
Last modified:October 1, 1994 - v1
Checksum:i629DF3C7C5AF88E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78214 Genomic DNA Translation: CAA55057.1
Z35798 Genomic DNA Translation: CAA84857.1
BK006936 Genomic DNA Translation: DAA07082.1
PIRiS50293
RefSeqiNP_009516.1, NM_001178277.1

Genome annotation databases

EnsemblFungiiYBL037W; YBL037W; YBL037W
GeneIDi852243
KEGGisce:YBL037W

Similar proteinsi

Entry informationi

Entry nameiAP2A_YEAST
AccessioniPrimary (citable) accession number: P38065
Secondary accession number(s): D6VPW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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