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Protein

60S ribosomal protein L32

Gene

RPL32

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-28980-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L321 Publication
Alternative name(s):
Large ribosomal subunit protein eL321 Publication
Gene namesi
Name:RPL321 Publication
Ordered Locus Names:YBL092W
ORF Names:YBL0838
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL092W
SGDiS000000188 RPL32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001311452 – 13060S ribosomal protein L32Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38061
PaxDbiP38061
PRIDEiP38061
TopDownProteomicsiP38061

PTM databases

CarbonylDBiP38061
iPTMnetiP38061

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi32611, 46 interactors
ComplexPortaliCPX-1601 60S cytosolic large ribosomal subunit
DIPiDIP-5176N
IntActiP38061, 11 interactors
MINTiP38061
STRINGi4932.YBL092W

Structurei

Secondary structure

1130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni20 – 24Combined sources5
Beta strandi26 – 28Combined sources3
Turni41 – 45Combined sources5
Helixi55 – 57Combined sources3
Helixi61 – 63Combined sources3
Beta strandi64 – 66Combined sources3
Beta strandi72 – 76Combined sources5
Helixi79 – 82Combined sources4
Turni83 – 86Combined sources4
Turni89 – 91Combined sources3
Beta strandi92 – 96Combined sources5
Helixi102 – 115Combined sources14
Beta strandi119 – 121Combined sources3
Beta strandi124 – 127Combined sources4

3D structure databases

ProteinModelPortaliP38061
SMRiP38061
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38061

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014729
HOGENOMiHOG000231288
InParanoidiP38061
KOiK02912
OMAiHPSGYEE
OrthoDBiEOG092C5E5Z

Family and domain databases

CDDicd00513 Ribosomal_L32_L32e, 1 hit
InterProiView protein in InterPro
IPR001515 Ribosomal_L32e
IPR018263 Ribosomal_L32e_CS
IPR036351 Ribosomal_L32e_sf
PANTHERiPTHR23413 PTHR23413, 1 hit
PfamiView protein in Pfam
PF01655 Ribosomal_L32e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003823 Ribosomal_L32e, 1 hit
SMARTiView protein in SMART
SM01393 Ribosomal_L32e, 1 hit
SUPFAMiSSF52042 SSF52042, 1 hit
PROSITEiView protein in PROSITE
PS00580 RIBOSOMAL_L32E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLPHPKIV KKHTKKFKRH HSDRYHRVAE NWRKQKGIDS VVRRRFRGNI
60 70 80 90 100
SQPKIGYGSN KKTKFLSPSG HKTFLVANVK DLETLTMHTK TYAAEIAHNI
110 120 130
SAKNRVVILA RAKALGIKVT NPKGRLALEA
Length:130
Mass (Da):14,771
Last modified:October 1, 1994 - v1
Checksum:i5C5EDD87D6841976
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA Translation: CAA56010.1
Z35853 Genomic DNA Translation: CAA84914.1
AY558291 Genomic DNA Translation: AAS56617.1
EF123124 mRNA Translation: ABM97468.1
BK006936 Genomic DNA Translation: DAA07031.1
PIRiS45410
RefSeqiNP_009460.1, NM_001178332.1

Genome annotation databases

EnsemblFungiiYBL092W; YBL092W; YBL092W
GeneIDi852185
KEGGisce:YBL092W

Similar proteinsi

Entry informationi

Entry nameiRL32_YEAST
AccessioniPrimary (citable) accession number: P38061
Secondary accession number(s): A2TBM1, D6VPR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 18, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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