Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Active sitei273Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei321Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-420-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:ML0375
ORF Names:B229_C3_243
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0375

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001145371 – 388Alanine racemaseAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0375

Structurei

3D structure databases

ProteinModelPortaliP38056
SMRiP38056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

P38056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTPISLRP GVLAEAVVDL GAIDYNVRVL REHAGMAQLM VVLKADAYGH
60 70 80 90 100
GATQVALAAL AAGAAELGVA TVDEALALRA DGISAPVLAW LHPPGIDFGP
110 120 130 140 150
ALLADVQIAV SSVRQLDELL DAVRRTGRTA TVTVKADTGL NRNGVVTDQY
160 170 180 190 200
PAMLTALQRA VVEDAVRLRG LMSHLVYADQ PDNPSNDVQG KRFAALLAQA
210 220 230 240 250
HEQGLRFEVA HLSNSSATMS RPDLAYDLVR PGIAVYGLSP VPSRGDMGLI
260 270 280 290 300
PAMTVKCAVA MVKSIRAGEG VSYGHDWIAQ HDTNLALLPV GYADGVFRSL
310 320 330 340 350
GGRLDVLING KRRPGVGRIC MDQFVVDLGP GPIDVAEGDE AILFGPGARG
360 370 380
EPTAQDWADL LGTIHYEVVT SLRGRITRTY REAQTVDR
Length:388
Mass (Da):41,083
Last modified:October 1, 1994 - v1
Checksum:iE4075B683D00D196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00020 Genomic DNA Translation: AAA17309.1
AL583918 Genomic DNA Translation: CAC29883.1
PIRiS72995
RefSeqiNP_301367.1, NC_002677.1
WP_010907691.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29883; CAC29883; CAC29883
GeneIDi909060
KEGGimle:ML0375
PATRICifig|272631.5.peg.637

Similar proteinsi

Entry informationi

Entry nameiALR_MYCLE
AccessioniPrimary (citable) accession number: P38056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health