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Protein

Uncharacterized fimbrial-like protein SfmF

Gene

sfmF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
  • cell adhesion involved in single-species biofilm formation Source: GO_Central
  • pilus organization Source: GO_Central

Enzyme and pathway databases

BioCyciEcoCyc:EG12388-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein SfmF
Gene namesi
Name:sfmF
Synonyms:ybcG
Ordered Locus Names:b0534, JW5072
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12388 sfmF

Subcellular locationi

GO - Cellular componenti

  • pilus Source: GO_Central

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000920821 – 171Uncharacterized fimbrial-like protein SfmFAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 80Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP38052
PRIDEiP38052

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263147, 12 interactors
STRINGi316385.ECDH10B_0490

Structurei

3D structure databases

ProteinModelPortaliP38052
SMRiP38052
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108ZI2 Bacteria
ENOG4111SMY LUCA
HOGENOMiHOG000260127
InParanoidiP38052
KOiK07355
PhylomeDBiP38052

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRVLFSCFC GLLWSSSGWA VDPLGTININ LHGNVVDFSC TVNTADIDKT
60 70 80 90 100
VDLGRWPTTQ LLNAGDTTAL VPFSLRLEGC PPGSVAILFT GTPASDTNLL
110 120 130 140 150
ALDDPAMAQT VAIELRNSDR SRLALGEASP TEEVDANGNV TLNFFANYRA
160 170
LASGVRPGVA KADAIFMINY N
Length:171
Mass (Da):18,223
Last modified:November 1, 1997 - v2
Checksum:i59230981242A1DCA
GO

Sequence cautioni

The sequence AAB40732 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40732.1 Different initiation.
U00096 Genomic DNA Translation: AAC73636.1
AP009048 Genomic DNA Translation: BAE76311.1
X51662 Genomic DNA No translation available.
PIRiE64785
RefSeqiNP_415067.1, NC_000913.3
WP_001255230.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73636; AAC73636; b0534
BAE76311; BAE76311; BAE76311
GeneIDi944977
KEGGiecj:JW5072
eco:b0534
PATRICifig|1411691.4.peg.1744

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA Translation: AAB40732.1 Different initiation.
U00096 Genomic DNA Translation: AAC73636.1
AP009048 Genomic DNA Translation: BAE76311.1
X51662 Genomic DNA No translation available.
PIRiE64785
RefSeqiNP_415067.1, NC_000913.3
WP_001255230.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP38052
SMRiP38052
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263147, 12 interactors
STRINGi316385.ECDH10B_0490

Proteomic databases

PaxDbiP38052
PRIDEiP38052

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73636; AAC73636; b0534
BAE76311; BAE76311; BAE76311
GeneIDi944977
KEGGiecj:JW5072
eco:b0534
PATRICifig|1411691.4.peg.1744

Organism-specific databases

EchoBASEiEB2289
EcoGeneiEG12388 sfmF

Phylogenomic databases

eggNOGiENOG4108ZI2 Bacteria
ENOG4111SMY LUCA
HOGENOMiHOG000260127
InParanoidiP38052
KOiK07355
PhylomeDBiP38052

Enzyme and pathway databases

BioCyciEcoCyc:EG12388-MONOMER

Miscellaneous databases

PROiPR:P38052

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSFMF_ECOLI
AccessioniPrimary (citable) accession number: P38052
Secondary accession number(s): P75716, P77079, Q2MBP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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Main funding by: National Institutes of Health

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