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UniProtKB - P38021 (OAT_BACSU)
Protein
Ornithine aminotransferase
Gene
rocD
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
1 PublicationCatalytic activityi
- EC:2.6.1.131 Publication
Cofactori
pyridoxal 5'-phosphateCurated
: L-proline biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine. This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- identical protein binding Source: GO_Central
- ornithine(lysine) transaminase activity Source: UniProtKB-EC
- ornithine-oxo-acid transaminase activity Source: UniProtKB
- pyridoxal phosphate binding Source: GO_Central
GO - Biological processi
- arginine metabolic process Source: UniProtKB
- L-proline biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Aminotransferase, Transferase |
Biological process | Amino-acid biosynthesis, Arginine metabolism, Proline biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BioCyci | BSUB:BSU40340-MONOMER |
UniPathwayi | UPA00098;UER00358 |
Names & Taxonomyi
Protein namesi | Recommended name: Ornithine aminotransferase (EC:2.6.1.131 Publication)Short name: OAT Alternative name(s): Ornithine--oxo-acid aminotransferase |
Gene namesi | Name:rocD1 Publication Ordered Locus Names:BSU40340 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Cells lacking this gene do not grow in minimal medium containing either arginine or ornithine as sole nitrogen source.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120503 | 1 – 401 | Ornithine aminotransferaseAdd BLAST | 401 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 258 | N6-(pyridoxal phosphate)lysineCurated | 1 |
Proteomic databases
jPOSTi | P38021 |
PaxDbi | P38021 |
PRIDEi | P38021 |
Expressioni
Inductioni
Part of the rocDEF operon. Expression is sigma L dependent, induced by arginine, ornithine, ctirulline or proline. Ammonium and glutamine strongly repress induction of the rocD by proline, and only glutamine represses weakly induction by arginine.2 Publications
Interactioni
GO - Molecular functioni
- identical protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 224308.BSU40340 |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.Curated
Phylogenomic databases
eggNOGi | COG4992, Bacteria |
InParanoidi | P38021 |
OMAi | DVFPRFA |
PhylomeDBi | P38021 |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_01689, Ornith_aminotrans_3, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR010164, Orn_aminotrans IPR034757, Ornith_aminotrans_bact IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
PANTHERi | PTHR11986:SF18, PTHR11986:SF18, 1 hit |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01885, Orn_aminotrans, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P38021-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTALSKSKEI IDQTSHYGAN NYHPLPIVIS EALGAWVKDP EGNEYMDMLS
60 70 80 90 100
AYSAVNQGHR HPKIIQALKD QADKITLTSR AFHNDQLGPF YEKTAKLTGK
110 120 130 140 150
EMILPMNTGA EAVESAVKAA RRWAYEVKGV ADNQAEIIAC VGNFHGRTML
160 170 180 190 200
AVSLSSEEEY KRGFGPMLPG IKLIPYGDVE ALRQAITPNT AAFLFEPIQG
210 220 230 240 250
EAGIVIPPEG FLQEAAAICK EENVLFIADE IQTGLGRTGK TFACDWDGIV
260 270 280 290 300
PDMYILGKAL GGGVFPISCI AADREILGVF NPGSHGSTFG GNPLACAVSI
310 320 330 340 350
ASLEVLEDEK LADRSLELGE YFKSELESID SPVIKEVRGR GLFIGVELTE
360 370 380 390 400
AARPYCERLK EEGLLCKETH DTVIRFAPPL IISKEDLDWA IEKIKHVLRN
A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81802 Genomic DNA Translation: CAA57398.1 D78193 Genomic DNA Translation: BAA11293.1 AL009126 Genomic DNA Translation: CAB16071.1 L22006 Unassigned DNA Translation: AAA19791.1 |
PIRi | S55793 |
RefSeqi | NP_391914.1, NC_000964.3 WP_003242970.1, NZ_JNCM01000034.1 |
Genome annotation databases
EnsemblBacteriai | CAB16071; CAB16071; BSU_40340 |
GeneIDi | 937755 |
KEGGi | bsu:BSU40340 |
PATRICi | fig|224308.179.peg.4364 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81802 Genomic DNA Translation: CAA57398.1 D78193 Genomic DNA Translation: BAA11293.1 AL009126 Genomic DNA Translation: CAB16071.1 L22006 Unassigned DNA Translation: AAA19791.1 |
PIRi | S55793 |
RefSeqi | NP_391914.1, NC_000964.3 WP_003242970.1, NZ_JNCM01000034.1 |
3D structure databases
AlphaFoldDBi | P38021 |
SMRi | P38021 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU40340 |
Proteomic databases
jPOSTi | P38021 |
PaxDbi | P38021 |
PRIDEi | P38021 |
Genome annotation databases
EnsemblBacteriai | CAB16071; CAB16071; BSU_40340 |
GeneIDi | 937755 |
KEGGi | bsu:BSU40340 |
PATRICi | fig|224308.179.peg.4364 |
Phylogenomic databases
eggNOGi | COG4992, Bacteria |
InParanoidi | P38021 |
OMAi | DVFPRFA |
PhylomeDBi | P38021 |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00358 |
BioCyci | BSUB:BSU40340-MONOMER |
Family and domain databases
CDDi | cd00610, OAT_like, 1 hit |
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_01689, Ornith_aminotrans_3, 1 hit |
InterProi | View protein in InterPro IPR005814, Aminotrans_3 IPR010164, Orn_aminotrans IPR034757, Ornith_aminotrans_bact IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small |
PANTHERi | PTHR11986:SF18, PTHR11986:SF18, 1 hit |
Pfami | View protein in Pfam PF00202, Aminotran_3, 1 hit |
PIRSFi | PIRSF000521, Transaminase_4ab_Lys_Orn, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01885, Orn_aminotrans, 1 hit |
PROSITEi | View protein in PROSITE PS00600, AA_TRANSFER_CLASS_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OAT_BACSU | |
Accessioni | P38021Primary (citable) accession number: P38021 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | February 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families